PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassicaceae incertae sedis; Schrenkiella

Family

C2H2

Protein Properties

Length: 342aa MW: 36888 Da PI: 8.3034

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Tp1g26830	genome	thellungiella	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	12.2	0.00054	36	59	1	23
EEETTTTEEESSHHHHHHHHHH.T CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirt.H 23 +kC+ C+k s+ s ++ H H Tp1g26830 36 FKCHVCHKKLSTASGMVIHVLQvH 59 89*****************87666 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50808	12.716	7	66	IPR003656	Zinc finger, BED-type
SMART	SM00355	20	12	35	IPR015880	Zinc finger, C2H2-like
SuperFamily	SSF57667	5.85E-5	12	61	No hit	No description
PROSITE pattern	PS00028	0	14	35	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.084	36	59	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	38	59	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009910	Biological Process	negative regulation of flower development
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0042803	Molecular Function	protein homodimerization activity
GO:0046872	Molecular Function	metal ion binding
GO:0046982	Molecular Function	protein heterodimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 342 aa Download sequence Send to blast
MGKKKKRATE KVWCYYCDRE FDDEKILVQH QKAKHFKCHV CHKKLSTASG MVIHVLQVHK 60 ENVTKVPNAK SGRDSTDIEI YGMQGIPPDV LAAHYGEEEE ESQAKAAKIE IPSAPLGGAV 120 PRPYGMVYQP QQVPGAVRPM YYPGAPMRPV GPGWPMPPPR PQQWYPQNPA ASVPPPAHLG 180 YRPQPLFPVH GMGMTMPPPS SVVSTPPGIP SPSPSMPVPQ PLFPVVNSST SQASPFSTPL 240 PVGGAQQPSP ADATIGSVNA YPPNNSFPVG GTNSHSYASG PNTGGPSVGP PPVIANKAPS 300 SQPNEVYLVW DDEAMSMEER RMSLPKYKVH DETSQVSSDL PF

Sequence ? help Back to Top

Protein Sequence Length: 342 aa Download sequence Send to blast

MGKKKKRATE KVWCYYCDRE FDDEKILVQH QKAKHFKCHV CHKKLSTASG MVIHVLQVHK  60
ENVTKVPNAK SGRDSTDIEI YGMQGIPPDV LAAHYGEEEE ESQAKAAKIE IPSAPLGGAV  120
PRPYGMVYQP QQVPGAVRPM YYPGAPMRPV GPGWPMPPPR PQQWYPQNPA ASVPPPAHLG  180
YRPQPLFPVH GMGMTMPPPS SVVSTPPGIP SPSPSMPVPQ PLFPVVNSST SQASPFSTPL  240
PVGGAQQPSP ADATIGSVNA YPPNNSFPVG GTNSHSYASG PNTGGPSVGP PPVIANKAPS  300
SQPNEVYLVW DDEAMSMEER RMSLPKYKVH DETSQVSSDL PF

Functional Description ? help Back to Top
Source	Description
UniProt	Sequence-specific DNA binding factor that recognizes the 5'-CCAAATTTTAAGTTT-3' sequence. Recruits the FRI-C complex to the FLC promoter. Required for FRI-mediated FLC activation, but has no effect on the expression of MAF1, MAF2, MAF3, MAF5, UFC and CO. Dispensable for the reactivation of FLC in early embryogenesis, but required to maintain high levels of FLC expression in later embryonic and vegetative development. {ECO:0000269\|PubMed:17079264, ECO:0000269\|PubMed:17138694, ECO:0000269\|PubMed:19121105, ECO:0000269\|PubMed:21282526}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Tp1g26830

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Not regulated by photoperiod or vernalization. {ECO:0000269\|PubMed:17079264, ECO:0000269\|PubMed:17138694}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK353116	0.0	AK353116.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-21-B03.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006305545.2	0.0	protein SUPPRESSOR OF FRI 4 isoform X1
Swissprot	Q9C5G0	0.0	SUF4_ARATH; Protein SUPPRESSOR OF FRI 4
TrEMBL	V4K7Y3	0.0	V4K7Y3_EUTSA; Uncharacterized protein
STRING	Bostr.15697s0404.1.p	0.0	(Boechera stricta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM7695	17	20

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G30970.1	1e-169	C2H2 family protein

Publications ? help Back to Top
Ding L,Kim SY,Michaels SD FLOWERING LOCUS C EXPRESSOR family proteins regulate FLOWERING LOCUS C expression in both winter-annual and rapid-cycling Arabidopsis. Plant Physiol., 2013. 163(1): p. 243-52 [PMID:23899645] Resentini F, et al. SUPPRESSOR OF FRIGIDA (SUF4) Supports Gamete Fusion via Regulating Arabidopsis EC1 Gene Expression. Plant Physiol., 2017. 173(1): p. 155-166 [PMID:27920160]