PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema

Family

ERF

Protein Properties

Length: 241aa MW: 26966.4 Da PI: 5.0797

Description

ERF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Thhalv10021421m	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	64.1	3e-20	78	127	2	55
AP2 2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55 y+G+r ++ +g+W+AeIrdp++ r++lg+f taeeAa a++aa+k+++g Thhalv10021421m 78 VYRGIRKRP-WGKWAAEIRDPRK---GVRVWLGTFNTAEEAAMAYDAAAKRIRG 127 69*****.******954...4**********************997 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF54171	4.38E-23	78	136	IPR016177	DNA-binding domain
Gene3D	G3DSA:3.30.730.10	1.6E-32	78	136	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	24.171	78	135	IPR001471	AP2/ERF domain
Pfam	PF00847	5.5E-14	78	127	IPR001471	AP2/ERF domain
SMART	SM00380	9.3E-37	78	141	IPR001471	AP2/ERF domain
PRINTS	PR00367	1.5E-11	79	90	IPR001471	AP2/ERF domain
CDD	cd00018	1.23E-18	79	134	No hit	No description
PRINTS	PR00367	1.5E-11	101	117	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008219	Biological Process	cell death
GO:0009723	Biological Process	response to ethylene
GO:0009735	Biological Process	response to cytokinin
GO:0009753	Biological Process	response to jasmonic acid
GO:0010286	Biological Process	heat acclimation
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051707	Biological Process	response to other organism
GO:0005634	Cellular Component	nucleus
GO:0005737	Cellular Component	cytoplasm
GO:0005886	Cellular Component	plasma membrane
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 241 aa Download sequence Send to blast
MCGGAIISDF TPFVTKAKGR KLTAEELWSE LDASAGDDFW GFDPTSKLRS TKQASVKEEA 60 AAEKEPTTTE KRRKRKNVYR GIRKRPWGKW AAEIRDPRKG VRVWLGTFNT AEEAAMAYDA 120 AAKRIRGDKA KLNFPDLLHH PPPPSPPRSI DQPPAKKLCV SSQSELTQPI YPVDCIGFGN 180 GDEFQEPSYA FDYDLKQQIS SLESFLELDG NTVEQPSQLD ESISEVVDMW MLDDVIDRLV 240 *

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
2gcc_A	3e-22	79	135	6	63	ATERF1
3gcc_A	3e-22	79	135	6	63	ATERF1
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	71	85	RRKRKNVYRGIRKRP

Functional Description ? help Back to Top
Source	Description
UniProt	Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). {ECO:0000250, ECO:0000269\|PubMed:9159183}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00109	PBM	Transfer from AT3G16770	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Thhalv10021421m

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By 1-aminocyclopropane-1-carboxylic acid (ACC, ethylene precursor), methyl jasmonate (MeJA), and Botrytis cinerea. Also induced by cadmium. {ECO:0000269\|PubMed:18836139, ECO:0000269\|PubMed:9159183}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK352663	0.0	AK352663.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-06-O05.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006406808.1	1e-178	ethylene-responsive transcription factor RAP2-3
Swissprot	P42736	1e-132	RAP23_ARATH; Ethylene-responsive transcription factor RAP2-3
TrEMBL	E4MVW6	1e-177	E4MVW6_EUTHA; mRNA, clone: RTFL01-06-O05
TrEMBL	V4NP12	1e-177	V4NP12_EUTSA; Uncharacterized protein
STRING	XP_006406808.1	1e-178	(Eutrema salsugineum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM10	28	1650

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G16770.1	1e-105	ethylene-responsive element binding protein

Link Out ? help Back to Top
Phytozome	Thhalv10021421m
Entrez Gene	18024989

Publications ? help Back to Top
Bueso E, et al. The lithium tolerance of the Arabidopsis cat2 mutant reveals a cross-talk between oxidative stress and ethylene. Plant J., 2007. 52(6): p. 1052-65 [PMID:17931347] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Chen YC, et al. Root defense analysis against Fusarium oxysporum reveals new regulators to confer resistance. Sci Rep, 2014. 4: p. 5584 [PMID:24998294] Deslauriers SD,Alvarez AA,Lacey RF,Binder BM,Larsen PB Dominant gain-of-function mutations in transmembrane domain III of ERS1 and ETR1 suggest a novel role for this domain in regulating the magnitude of ethylene response in Arabidopsis. New Phytol., 2015. 208(2): p. 442-55 [PMID:25988998] Bui LT,Giuntoli B,Kosmacz M,Parlanti S,Licausi F Constitutively expressed ERF-VII transcription factors redundantly activate the core anaerobic response in Arabidopsis thaliana. Plant Sci., 2015. 236: p. 37-43 [PMID:26025519] Gasch P, et al. Redundant ERF-VII Transcription Factors Bind to an Evolutionarily Conserved cis-Motif to Regulate Hypoxia-Responsive Gene Expression in Arabidopsis. Plant Cell, 2016. 28(1): p. 160-80 [PMID:26668304] Liu W, et al. Ethylene response factor AtERF72 negatively regulates Arabidopsis thaliana response to iron deficiency. Biochem. Biophys. Res. Commun., 2017. 491(3): p. 862-868 [PMID:28390898] Yao Y,Chen X,Wu AM ERF-VII members exhibit synergistic and separate roles in Arabidopsis. Plant Signal Behav, 2017. 12(6): p. e1329073 [PMID:28537474]