PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Thhalv10008172m

Common Name

EUTSA_v10008172mg

Organism

Eutrema salsugineum

Taxonomic ID

72664

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema

Family

BES1

Protein Properties

Length: 330aa MW: 35939.9 Da PI: 9.8643

Description

BES1 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Thhalv10008172m	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	DUF822	199.1	1.4e-61	15	150	2	144
DUF822 2 gsgrkptwkErEnnkrRERrRRaiaakiyaGLRaqGnyklpkraDnneVlkALcreAGwvvedDGttyrkgskpleeaeaagssasaspesslq 95 +++rkp+w+ErEnn+rRERrRRa+aakiy+GLRaqGny+lpk++DnneVlkALc eAGwvve+DGttyrkg kpl ++agss++++p ss + Thhalv10008172m 15 ATRRKPSWRERENNRRRERRRRAVAAKIYTGLRAQGNYNLPKHCDNNEVLKALCSEAGWVVEEDGTTYRKGHKPL-PGDMAGSSSRVTPYSSHN 107 689**********************************************************************.************77 PP DUF822 96 sslkssalaspvesysaspksssfpspssldsislasaasllpvlsvls 144 s ++sp+ sy+ sp+sssfpsps+ +++ ++++p+l++ + Thhalv10008172m 108 ----QSPFESPILSYQVSPSSSSFPSPSRGGDTHNI--SNIFPFLRNGG 150 ....889*******************98777665..68888888775 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Pfam	PF05687	3.4E-58	16	133	IPR008540	BES1/BZR1 plant transcription factor, N-terminal

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009742	Biological Process	brassinosteroid mediated signaling pathway
GO:0042742	Biological Process	defense response to bacterium
GO:0045892	Biological Process	negative regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005829	Cellular Component	cytosol
GO:0001046	Molecular Function	core promoter sequence-specific DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 330 aa Download sequence Send to blast
MTSDGATSTS AAAMATRRKP SWRERENNRR RERRRRAVAA KIYTGLRAQG NYNLPKHCDN 60 NEVLKALCSE AGWVVEEDGT TYRKGHKPLP GDMAGSSSRV TPYSSHNQSP FESPILSYQV 120 SPSSSSFPSP SRGGDTHNIS NIFPFLRNGG IPSSLPPLRI SNSAPVTPPV SSPTSKNHPK 180 PLPTWESFTK QSMAIAAKQS ISSFNYPFYA VSAPASPTHH RQFNAPATIP ECDESDSSTV 240 DSGHWISFQK FPQQPFHAGP GVPASPTFNL VKPPAPQQLS PNTAANREIG QSSEFKFENS 300 QVKPWEGERI HDVAMEDLEL TLGNAKGRS*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5zd4_A	5e-36	17	99	371	453	Maltose-binding periplasmic protein,Protein BRASSINAZOLE-RESISTANT 1
5zd4_B	5e-36	17	99	371	453	Maltose-binding periplasmic protein,Protein BRASSINAZOLE-RESISTANT 1
5zd4_C	5e-36	17	99	371	453	Maltose-binding periplasmic protein,Protein BRASSINAZOLE-RESISTANT 1
5zd4_D	5e-36	17	99	371	453	Maltose-binding periplasmic protein,Protein BRASSINAZOLE-RESISTANT 1
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	16	35	RRKPSWRERENNRRRERRRR

Functional Description ? help Back to Top
Source	Description
UniProt	Positive regulator of brassinosteroid (BR) signaling. Transcription factor that activates target gene expression by binding specifically to the DNA sequence 5'-CANNTG-3'(E box) through its N-terminal domain. Can bind individually to the promoter as a homodimer or synergistically as a heterodimer with BIM1, BIM2 or BIM3. The C-terminal domain is probably involved in transcriptional activation (PubMed:12007405, PubMed:15680330, PubMed:18467490, PubMed:19170933). Recruits the transcription elongation factor IWS1 to control BR-regulated gene expression (PubMed:20139304). Forms a trimeric complex with IWS1 and ASHH2/SDG8 to regulate BR-regulated gene expression (PubMed:24838002). Promotes quiescent center (QC) self-renewal by cell divisions in the primary root. Binds to the E-boxes of the BRAVO promoter to repress its expression (PubMed:24981610). {ECO:0000269\|PubMed:12007405, ECO:0000269\|PubMed:15680330, ECO:0000269\|PubMed:18467490, ECO:0000269\|PubMed:19170933, ECO:0000269\|PubMed:20139304, ECO:0000269\|PubMed:24838002, ECO:0000269\|PubMed:24981610}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00073	ChIP-chip	Transfer from AT1G19350	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Thhalv10008172m

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK352751	0.0	AK352751.1 Thellungiella halophila mRNA, complete cds, clone: RTFL01-07-K05.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006416513.1	0.0	protein BRASSINAZOLE-RESISTANT 2
Refseq	XP_006416514.1	0.0	protein BRASSINAZOLE-RESISTANT 2
Swissprot	Q9LN63	0.0	BZR2_ARATH; Protein BRASSINAZOLE-RESISTANT 2
TrEMBL	E4MW54	0.0	E4MW54_EUTHA; mRNA, clone: RTFL01-07-K05
TrEMBL	V4KXU8	0.0	V4KXU8_EUTSA; Uncharacterized protein
STRING	XP_006416513.1	0.0	(Eutrema salsugineum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM2472	27	72

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G19350.3	1e-167	BES1 family protein

Link Out ? help Back to Top
Phytozome	Thhalv10008172m
Entrez Gene	18992988

Publications ? help Back to Top
Salazar-Henao JE,Lehner R,Betegón-Putze I,Vilarrasa-Blasi J,Caño-Delgado AI BES1 regulates the localization of the brassinosteroid receptor BRL3 within the provascular tissue of the Arabidopsis primary root. J. Exp. Bot., 2016. 67(17): p. 4951-61 [PMID:27511026] Nolan T, et al. Identification of Brassinosteroid Target Genes by Chromatin Immunoprecipitation Followed by High-Throughput Sequencing (ChIP-seq) and RNA-Sequencing. Methods Mol. Biol., 2017. 1564: p. 63-79 [PMID:28124247] Ye H, et al. RD26 mediates crosstalk between drought and brassinosteroid signalling pathways. Nat Commun, 2017. 8: p. 14573 [PMID:28233777] Nolan TM, et al. Selective Autophagy of BES1 Mediated by DSK2 Balances Plant Growth and Survival. Dev. Cell, 2017. 41(1): p. 33-46.e7 [PMID:28399398] Yang M, et al. SINAT E3 Ligases Control the Light-Mediated Stability of the Brassinosteroid-Activated Transcription Factor BES1 in Arabidopsis. Dev. Cell, 2017. 41(1): p. 47-58.e4 [PMID:28399399] Chen J, et al. Arabidopsis WRKY46, WRKY54, and WRKY70 Transcription Factors Are Involved in Brassinosteroid-Regulated Plant Growth and Drought Responses. Plant Cell, 2017. 29(6): p. 1425-1439 [PMID:28576847] Yang M,Wang X Multiple Ways of BES1/BZR1 Degradation to Decode Distinct Developmental and Environmental Cues in Plants. Mol Plant, 2017. 10(7): p. 915-917 [PMID:28629641] Saito M,Kondo Y,Fukuda H BES1 and BZR1 Redundantly Promote Phloem and Xylem Differentiation. Plant Cell Physiol., 2018. 59(3): p. 590-600 [PMID:29385529] Liang T, et al. UVR8 Interacts with BES1 and BIM1 to Regulate Transcription and Photomorphogenesis in Arabidopsis. Dev. Cell, 2018. 44(4): p. 512-523.e5 [PMID:29398622]