PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Malvales; Malvaceae; Byttnerioideae; Theobroma

Family

MYB_related

Protein Properties

Length: 414aa MW: 46591.3 Da PI: 4.9981

Description

MYB_related family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Thecc1EG030408t3	genome	CGD	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	34.8	3.9e-11	13	54	4	46
S-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS Myb_DNA-binding 4 WTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46 W ++++ ll+++++++G g+W+ +a+++g ++t + c++++ + Thecc1EG030408t3 13 WNADDEILLLEGIEMYGLGNWAEVAEHVG-TKTKEKCIEHYDN 54 ***************************.********976 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PIRSF	PIRSF025024	1.7E-101	1	402	IPR016827	Transcriptional adaptor 2
SuperFamily	SSF46689	3.81E-12	6	59	IPR009057	Homeodomain-like
PROSITE profile	PS51293	20.124	8	60	IPR017884	SANT domain
SMART	SM00717	7.0E-11	9	58	IPR001005	SANT/Myb domain
Pfam	PF00249	9.8E-11	12	54	IPR001005	SANT/Myb domain
CDD	cd00167	7.17E-11	13	55	No hit	No description
Gene3D	G3DSA:1.10.10.60	2.4E-7	13	56	IPR009057	Homeodomain-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006357	Biological Process	regulation of transcription from RNA polymerase II promoter
GO:0009631	Biological Process	cold acclimation
GO:0009733	Biological Process	response to auxin
GO:0009735	Biological Process	response to cytokinin
GO:0016573	Biological Process	histone acetylation
GO:0042127	Biological Process	regulation of cell proliferation
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0003713	Molecular Function	transcription coactivator activity
GO:0005515	Molecular Function	protein binding
GO:0008270	Molecular Function	zinc ion binding
GO:0016740	Molecular Function	transferase activity

Sequence ? help Back to Top
Protein Sequence Length: 414 aa Download sequence Send to blast
MDNLSFPLIC PDWNADDEIL LLEGIEMYGL GNWAEVAEHV GTKTKEKCIE HYDNVYMKSP 60 FFPLPDMSHV VGKNRKELLA MAKGHGEDKK GSSMLGELTV KEESPFSPSR VKVEGGPSGR 120 LLSGLNADVE SGVRSSSSST TPAAVNKASN MAQVKDGNVK MEDPQMDRKG KKPNSLGNDG 180 LVELSGYNPK RQEFDPEYDN DAEQLLAEME FKDTDTEEEH EIKLRVLRIY SKRLDERKRR 240 KDFILERNLL YPNPFEKDLT PEERALCRRY DVFMRFLSKE EHEDLLQTIV SEHRTLKRIE 300 ELKEARAAGC RTSAEADRYL ELKRKREAEE SSHRAKDGVH VNPSGQGGPN SFMASESVAK 360 DSNSRPTAQA SSSFATDLDI MGFSETQLLS EAEFACNLHA LLYLSVIWLE SFN*

Sequence ? help Back to Top

Protein Sequence Length: 414 aa Download sequence Send to blast

MDNLSFPLIC PDWNADDEIL LLEGIEMYGL GNWAEVAEHV GTKTKEKCIE HYDNVYMKSP  60
FFPLPDMSHV VGKNRKELLA MAKGHGEDKK GSSMLGELTV KEESPFSPSR VKVEGGPSGR  120
LLSGLNADVE SGVRSSSSST TPAAVNKASN MAQVKDGNVK MEDPQMDRKG KKPNSLGNDG  180
LVELSGYNPK RQEFDPEYDN DAEQLLAEME FKDTDTEEEH EIKLRVLRIY SKRLDERKRR  240
KDFILERNLL YPNPFEKDLT PEERALCRRY DVFMRFLSKE EHEDLLQTIV SEHRTLKRIE  300
ELKEARAAGC RTSAEADRYL ELKRKREAEE SSHRAKDGVH VNPSGQGGPN SFMASESVAK  360
DSNSRPTAQA SSSFATDLDI MGFSETQLLS EAEFACNLHA LLYLSVIWLE SFN*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
6cw3_E	2e-19	5	68	57	120	Transcriptional adapter 2
6cw3_G	2e-19	5	68	57	120	Transcriptional adapter 2
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	236	241	RKRRKD

Functional Description ? help Back to Top
Source	Description
UniProt	Required for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known (By similarity). ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region. Mediates auxin and cytokinin signals in the control of cell proliferation and might be involved in repression of a freezing tolerance pathway at warm temperature (PubMed:12615937, PubMed:12747832). Involved in the positive regulation of salt-induced gene expression by maintaining locus-specific acetylation of histones H4 and H3 (PubMed:21193996). {ECO:0000250, ECO:0000269\|PubMed:12615937, ECO:0000269\|PubMed:12747832, ECO:0000269\|PubMed:21193996}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_007026321.2	0.0	PREDICTED: transcriptional adapter ADA2b isoform X2
Swissprot	Q9ATB4	1e-154	TAD2B_ARATH; Transcriptional adapter ADA2b
TrEMBL	A0A061GP83	0.0	A0A061GP83_THECC; Transcriptional adapter
STRING	EOY28942	0.0	(Theobroma cacao)

Link Out ? help Back to Top
Phytozome	Thecc1EG030408t3
Entrez Gene	18597313

Publications ? help Back to Top
Vlachonasios KE,Thomashow MF,Triezenberg SJ Disruption mutations of ADA2b and GCN5 transcriptional adaptor genes dramatically affect Arabidopsis growth, development, and gene expression. Plant Cell, 2003. 15(3): p. 626-38 [PMID:12615937] Sieberer T,Hauser MT,Seifert GJ,Luschnig C PROPORZ1, a putative Arabidopsis transcriptional adaptor protein, mediates auxin and cytokinin signals in the control of cell proliferation. Curr. Biol., 2003. 13(10): p. 837-42 [PMID:12747832] Kerschen A,Napoli CA,Jorgensen RA,Müller AE Effectiveness of RNA interference in transgenic plants. FEBS Lett., 2004. 566(1-3): p. 223-8 [PMID:15147899] Hark AT, et al. Two Arabidopsis orthologs of the transcriptional coactivator ADA2 have distinct biological functions. Biochim. Biophys. Acta, 2009. 1789(2): p. 117-24 [PMID:18929690] Anzola JM, et al. Putative Arabidopsis transcriptional adaptor protein (PROPORZ1) is required to modulate histone acetylation in response to auxin. Proc. Natl. Acad. Sci. U.S.A., 2010. 107(22): p. 10308-13 [PMID:20479223] Kaldis A,Tsementzi D,Tanriverdi O,Vlachonasios KE Arabidopsis thaliana transcriptional co-activators ADA2b and SGF29a are implicated in salt stress responses. Planta, 2011. 233(4): p. 749-62 [PMID:21193996] Vlachonasios KE,Kaldis A,Nikoloudi A,Tsementzi D The role of transcriptional coactivator ADA2b in Arabidopsis abiotic stress responses. Plant Signal Behav, 2011. 6(10): p. 1475-8 [PMID:21897124] Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Motamayor JC, et al. The genome sequence of the most widely cultivated cacao type and its use to identify candidate genes regulating pod color. Genome Biol., 2013. 14(6): p. r53 [PMID:23731509] Kazama D,Kurusu T,Mitsuda N,Ohme-Takagi M,Tada Y Involvement of elevated proline accumulation in enhanced osmotic stress tolerance in Arabidopsis conferred by chimeric repressor gene silencing technology. Plant Signal Behav, 2014. 9(3): p. e28211 [PMID:24614501] Kim JY,Oh JE,Noh YS,Noh B Epigenetic control of juvenile-to-adult phase transition by the Arabidopsis SAGA-like complex. Plant J., 2015. 83(3): p. 537-45 [PMID:26095998] Kazama D, et al. Identification of Chimeric Repressors that Confer Salt and Osmotic Stress Tolerance in Arabidopsis. Plants (Basel), 2013. 2(4): p. 769-85 [PMID:27137403] Simon MK,Skinner DJ,Gallagher TL,Gasser CS Integument Development in Arabidopsis Depends on Interaction of YABBY Protein INNER NO OUTER with Coactivators and Corepressors. Genetics, 2017. 207(4): p. 1489-1500 [PMID:28971961] Lai J, et al. The Transcriptional Coactivator ADA2b Recruits a Structural Maintenance Protein to Double-Strand Breaks during DNA Repair in Plants. Plant Physiol., 2018. 176(4): p. 2613-2622 [PMID:29463775] Kotak J, et al. The histone acetyltransferase GCN5 and the transcriptional coactivator ADA2b affect leaf development and trichome morphogenesis in Arabidopsis. Planta, 2018. 248(3): p. 613-628 [PMID:29846775]