PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum; Lycopersicon

Family

HSF

Protein Properties

Length: 528aa MW: 57711.7 Da PI: 4.964

Description

HSF family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Sopen08g001190.1	genome	spenn	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HSF_DNA-bind	116.8	1.3e-36	42	133	2	102
HHHHHHHHHCTGGGTTTSEESSSSSEEEES-HHHHHHHTHHHHSTT--HHHHHHHHHHTTEEE---SSBTTTTXTTSEEEEESXXXXXXXXXX CS HSF_DNA-bind 2 FlkklyeiledeelkeliswsengnsfvvldeeefakkvLpkyFkhsnfaSFvRQLnmYgFkkvkdeekkskskekiweFkhksFkkgkkell 94 Fl k+y++++d+++++++sws ++nsfvv+d+ efak++LpkyFkh+nf+SFvRQLn+YgF+kv+ ++ weF+++ F +g+k+ll Sopen08g001190.1 42 FLVKTYDMVDDPSTDKIVSWSPTNNSFVVWDPPEFAKDLLPKYFKHNNFSSFVRQLNTYGFRKVDPDR---------WEFANEGFLRGQKHLL 125 9******************999*************************************999.........************ PP XXXXXXXX CS HSF_DNA-bind 95 ekikrkks 102 ++i r+k Sopen08g001190.1 126 KSISRRKP 133 ***986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.0E-40	35	126	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	9.52E-37	37	131	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM00415	2.2E-65	38	131	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	1.2E-20	42	65	IPR000232	Heat shock factor (HSF)-type, DNA-binding
Pfam	PF00447	1.0E-32	42	131	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	1.2E-20	80	92	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PROSITE pattern	PS00434	0	81	105	IPR000232	Heat shock factor (HSF)-type, DNA-binding
PRINTS	PR00056	1.2E-20	93	105	IPR000232	Heat shock factor (HSF)-type, DNA-binding

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009408	Biological Process	response to heat
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 528 aa Download sequence Send to blast
MEPNSYGSGK AAVGDGVGVG VGAPMLQTAP APIPSANAPP PFLVKTYDMV DDPSTDKIVS 60 WSPTNNSFVV WDPPEFAKDL LPKYFKHNNF SSFVRQLNTY GFRKVDPDRW EFANEGFLRG 120 QKHLLKSISR RKPAHGHAQQ QQQPHGHAQQ QMQPPGHSAS VGACVEVGKF GLEEEVERLK 180 RDKNVLMQEL VRLRQQQQAT DNQLQGMVQR LQGMELRQQQ MMSFLAKAVN SPGFLAQFVQ 240 QQNESNKRIA EGSKKRRIKQ DIESQDPSVT PADGQIVKYQ PGINEAAKAM LRELSKLDSS 300 PRLDNFSNSP ESFLIGDGSP QSNASSGRVS GVTLQEVPPT SGKPLLNTAS AIAGQSLLPA 360 TSEMQSSHLG TCSEIINNQL SNIIPLVGGE DLHPGSLSAS DMIMPELSQL QGILPENNTD 420 VIGCDSFMDT SAVEGKMGLD IIGSLSPGAD IDWQSGLLDE IEEFPSVGDP FWEKFLQSPS 480 SPDAAMDDDI SNTSETKPQI NGWDKTQNME HLTEQMGATN IKQQKHMI

Sequence ? help Back to Top

Protein Sequence Length: 528 aa Download sequence Send to blast

MEPNSYGSGK AAVGDGVGVG VGAPMLQTAP APIPSANAPP PFLVKTYDMV DDPSTDKIVS  60
WSPTNNSFVV WDPPEFAKDL LPKYFKHNNF SSFVRQLNTY GFRKVDPDRW EFANEGFLRG  120
QKHLLKSISR RKPAHGHAQQ QQQPHGHAQQ QMQPPGHSAS VGACVEVGKF GLEEEVERLK  180
RDKNVLMQEL VRLRQQQQAT DNQLQGMVQR LQGMELRQQQ MMSFLAKAVN SPGFLAQFVQ  240
QQNESNKRIA EGSKKRRIKQ DIESQDPSVT PADGQIVKYQ PGINEAAKAM LRELSKLDSS  300
PRLDNFSNSP ESFLIGDGSP QSNASSGRVS GVTLQEVPPT SGKPLLNTAS AIAGQSLLPA  360
TSEMQSSHLG TCSEIINNQL SNIIPLVGGE DLHPGSLSAS DMIMPELSQL QGILPENNTD  420
VIGCDSFMDT SAVEGKMGLD IIGSLSPGAD IDWQSGLLDE IEEFPSVGDP FWEKFLQSPS  480
SPDAAMDDDI SNTSETKPQI NGWDKTQNME HLTEQMGATN IKQQKHMI

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5d5u_B	5e-29	16	131	4	129	Heat shock factor protein 1
5d5v_B	5e-29	16	131	4	129	Heat shock factor protein 1
5d5v_D	5e-29	16	131	4	129	Heat shock factor protein 1
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	253	258	KKRRIK

Functional Description ? help Back to Top
Source	Description
UniProt	DNA-binding protein that specifically binds heat shock promoter elements (HSE) and activates transcription. {ECO:0000250}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	X67600	0.0	X67600.1 L.peruvianum Lp-hsf8 mRNA for heat stress transcription factor 8.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015085676.1	0.0	heat shock factor protein HSF8
Swissprot	Q40152	0.0	HSF8_SOLLC; Heat shock factor protein HSF8
TrEMBL	M1BII2	0.0	M1BII2_SOLTU; Uncharacterized protein
STRING	Solyc08g005170.2.1	0.0	(Solanum lycopersicum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA6413	19	31

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G32330.1	1e-134	heat shock transcription factor A1D

Publications ? help Back to Top
Zhu B, et al. Identification and characterization of a novel heat shock transcription factor gene, GmHsfA1, in soybeans (Glycine max). J. Plant Res., 2006. 119(3): p. 247-56 [PMID:16570125] Cai SY, et al. HsfA1a upregulates melatonin biosynthesis to confer cadmium tolerance in tomato plants. J. Pineal Res., 2017. [PMID:28095626] Zhou J, et al. Heat Shock Factor HsfA1a Is Essential for R Gene-Mediated Nematode Resistance and Triggers H2O2 Production1. Plant Physiol., 2018. 176(3): p. 2456-2471 [PMID:29339397]