PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Solyc08g076930.1.1
Organism
Solanum lycopersicum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Solanoideae; Solaneae; Solanum; Lycopersicon
Family bHLH
Protein Properties Length: 690aa    MW: 75041.1 Da    PI: 5.4512
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Solyc08g076930.1.1genomeITAGView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.11.4e-12513558454
                         HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
                 HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                         +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  Solyc08g076930.1.1 513 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAISYINEL 558
                         799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142153.2E-5694277IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.39509558IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474592.88E-18512581IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000832.70E-15512563No hitNo description
PfamPF000104.4E-10513558IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.101.1E-18513580IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003531.4E-16515564IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009269Biological Processresponse to desiccation
GO:0009611Biological Processresponse to wounding
GO:0009737Biological Processresponse to abscisic acid
GO:0009867Biological Processjasmonic acid mediated signaling pathway
GO:0009963Biological Processpositive regulation of flavonoid biosynthetic process
GO:0010200Biological Processresponse to chitin
GO:0043619Biological Processregulation of transcription from RNA polymerase II promoter in response to oxidative stress
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0051090Biological Processregulation of sequence-specific DNA binding transcription factor activity
GO:2000068Biological Processregulation of defense response to insect
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 690 aa     Download sequence    Send to blast
MTEYSLPTMN LWNNSTSDDN VSMMEAFMSS DLSFWATNNS TSAAVVGVNS NLPHASSNTP  60
SVFAPSSSTS ASTLSAAATV DASKSMPFFN QETLQQRLQA LIDGARETWT YAIFWQSSVV  120
DFSSPSVLGW GDGYYKGEED KAKRKLSVSS PAYIAEQEHR KKVLRELNSL ISGAPPGTDD  180
AVDEEVTDTE WFFLISMTQS FVNGSGLPGQ ALYSSSPIWV AGTEKLAASH CERVRQAQGF  240
GLQTIVCIPS ANGVVELGST ELIVQSSDLM NKVRVLFNFS NDLGSGSWAV QPESDPSALW  300
LTDPSSSGME VRESLNTVQT NSVPSSNSNK QIAYGNENNH PSGNGQSCYN QQQQKNPPQQ  360
QTQGFFTREL NFSEFGFDGS SNRNGNSSVS CKPESGEILN FGDSTKKSAS SANVNLFTGQ  420
SQFGAGEENN NKNKKRSATS RGSNEEGMLS FVSGTVLPSS GMKSGGGGGE DSEHSDLEAS  480
VVKEADSSRV VEPEKRPRKR GRKPANGREE PLNHVEAERQ RREKLNQRFY ALRAVVPNVS  540
KMDKASLLGD AISYINELKS KLQNTESDKE DLKSQIEDLK KESRRPGPPP PPNQDLKMSS  600
HTGGKIVDVD IDVKIIGWDA MIRIQCNKKN HPAARLMAAL MELDLDVHHA SVSVVNDLMI  660
QQATVKMGSR HYTEEQLRVA LTSKIAETH*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4rqw_A4e-71872792194Transcription factor MYC3
4rqw_B4e-71872792194Transcription factor MYC3
4rs9_A4e-71872792194Transcription factor MYC3
4yz6_A4e-71872792194Transcription factor MYC3
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1494502KRPRKRGRK
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Les.35420.0callus| flower| fruit| leaf| stem
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed at low levels in roots, stems, leaves, flowers and fruits. {ECO:0000269|PubMed:15231736}.
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Function -- GeneRIF ? help Back to Top
  1. MYC2 and the MTF ETHYLENE RESPONSE FACTOR.C3 form a transcription module that preferentially regulates pathogen-responsive genes.
    [PMID: 28733419]
  2. Methyl Jasmonate markedly induced the MYC2 expression; increased proline content, lycopene content, and antioxidant enzyme activities and involved in chilling tolerance.
    [PMID: 29528226]
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00084PBMTransfer from AT1G32640Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapSolyc08g076930.1.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAF0115570.0Lycopersicon esculentum jasmonic acid 3 (LEJA3) mRNA, partial cds
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqNP_001311412.10.0transcription factor MYC2
SwissprotA0A3Q7HRZ60.0MYC2_SOLLC; Transcription factor MYC2
TrEMBLM1BHA00.0M1BHA0_SOLTU; Uncharacterized protein
STRINGSolyc08g076930.1.10.0(Solanum lycopersicum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA33002449
Representative plantOGRP37331224
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.11e-178bHLH family protein
Publications ? help Back to Top
  1. Wang Y,van der Hoeven RS,Nielsen R,Mueller LA,Tanksley SD
    Characteristics of the tomato nuclear genome as determined by sequencing undermethylated EcoRI digested fragments.
    Theor. Appl. Genet., 2005. 112(1): p. 72-84
    [PMID:16208505]
  2. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  3. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  4. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  5. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  6. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  7. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  8. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]