PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; PACMAD clade; Panicoideae; Andropogonodae; Andropogoneae; Sorghinae; Sorghum

Family

E2F/DP

Protein Properties

Length: 472aa MW: 52038.7 Da PI: 5.0322

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Sobic.004G168300.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	83.3	2e-26	145	209	1	70
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwk 70 r+++sL+llt+kf++ll+++++gi++ln++a++L +v ++RRiYDi+NVLe+++liek+ kn+irwk Sobic.004G168300.1.p 145 RYDSSLGLLTKKFINLLKQAPDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWK 209 6899****************************...99..**************************8 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.2E-27	143	211	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	9.25E-18	145	208	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	5.3E-34	145	210	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	7.6E-24	147	209	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	7.59E-25	241	324	No hit	No description
CDD	cd14660	5.34E-38	243	324	No hit	No description
Pfam	PF16421	4.5E-25	243	322	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 472 aa Download sequence Send to blast
MSGLGSGRPQ AAQKILQSLR PPLSFASPSR PPFAAPDEYH RFPTPAAATG PGATSGGVGV 60 GGDPPDTIEE GLVLRTPLKR KARSVENDTA ESSDCIITSP MLTPVSGKTV KASKAKAKNS 120 KAGPQTPTSN VGSPLNPPTP VGTCRYDSSL GLLTKKFINL LKQAPDGILD LNNAAETLEV 180 QKRRIYDITN VLEGIGLIEK TLKNRIRWKA LDDSSVHLDN GISALQFLTK ALCNQVLCFP 240 FSDMREKLRE LTEDENNKRW IYVTEDDIKG LPSFQNYTLI AIKAPHGTTL EVPDPDEAGD 300 YLQRRYRIVL RSTMGPIDVY LVSQFDENIE ELGDVMPRHQ PTEDFNTTYA AQSSTPIDVA 360 HDVQQSQKIP QDPSTLHDFG GMTRLTASDV QTSDYWLLTE GDVSMTDIWR TERILDNHSL 420 SYLKFLAWKI EEVQWDQMDF LSEDVVTPRA HNQQPVTADG PHMEVPSMDK P*

Sequence ? help Back to Top

Protein Sequence Length: 472 aa Download sequence Send to blast

MSGLGSGRPQ AAQKILQSLR PPLSFASPSR PPFAAPDEYH RFPTPAAATG PGATSGGVGV  60
GGDPPDTIEE GLVLRTPLKR KARSVENDTA ESSDCIITSP MLTPVSGKTV KASKAKAKNS  120
KAGPQTPTSN VGSPLNPPTP VGTCRYDSSL GLLTKKFINL LKQAPDGILD LNNAAETLEV  180
QKRRIYDITN VLEGIGLIEK TLKNRIRWKA LDDSSVHLDN GISALQFLTK ALCNQVLCFP  240
FSDMREKLRE LTEDENNKRW IYVTEDDIKG LPSFQNYTLI AIKAPHGTTL EVPDPDEAGD  300
YLQRRYRIVL RSTMGPIDVY LVSQFDENIE ELGDVMPRHQ PTEDFNTTYA AQSSTPIDVA  360
HDVQQSQKIP QDPSTLHDFG GMTRLTASDV QTSDYWLLTE GDVSMTDIWR TERILDNHSL  420
SYLKFLAWKI EEVQWDQMDF LSEDVVTPRA HNQQPVTADG PHMEVPSMDK P*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	6e-23	137	211	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
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Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	77	83	LKRKARS

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant in early S phase. Decreased expression during the passage into G2. {ECO:0000269\|PubMed:11108847, ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543}.
Uniprot	TISSUE SPECIFICITY: Highly expressed in the shoot apical meristem, emerging leaf primordia, and vascular tissues of young leaf primordia. Expressed in flowers, in epidermis and cortex of hypocotyls, and at lower levels in leaves. {ECO:0000269\|PubMed:11108847, ECO:0000269\|PubMed:11889041}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Sobic.004G168300.1.p

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	JX469963	0.0	JX469963.1 Zea mays subsp. mays clone UT3225 E2F-DP-type transcription factor mRNA, partial cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_002453944.2	0.0	transcription factor E2FA
Swissprot	Q9FNY0	1e-114	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A1Z5RMW7	0.0	A0A1Z5RMW7_SORBI; Uncharacterized protein
STRING	AC233850.1_FGP005	0.0	(Zea mays)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP625	37	148
Representative plant	OGRP1225	17	49

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.3	1e-104	E2F transcription factor 3

Link Out ? help Back to Top
Phytozome	Sobic.004G168300.1.p

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]