PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Salicaceae; Saliceae; Salix

Family

C2H2

Protein Properties

Length: 297aa MW: 34009.7 Da PI: 6.4061

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
SapurV1A.0618s0030.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	22.1	4e-07	24	48	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 ++Cp Cgk Fs nL++H++tH SapurV1A.0618s0030.1.p 24 FVCPheGCGKAFSLDFNLRSHMKTH 48 89**********************9 PP
2	zf-C2H2	14.9	7.9e-05	54	78	1	23
EEET..TTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirtH 23 + Cp Cgk++ + + Lk+Hi +H SapurV1A.0618s0030.1.p 54 HICPhpECGKRYAHEYKLKNHIASH 78 679999*****************96 PP
3	zf-C2H2	13.4	0.00022	152	177	1	23
EEET..TTTEEESSHHHHHHHHHH.T CS zf-C2H2 1 ykCp..dCgksFsrksnLkrHirt.H 23 y Cp C k + + + Lk H+r+ H SapurV1A.0618s0030.1.p 152 YICPyeGCEKDYIHEYKLKLHLRReH 177 89**********************99 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	3.41E-14	5	58	No hit	No description
Gene3D	G3DSA:3.30.160.60	3.9E-20	8	50	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	12.695	24	53	IPR007087	Zinc finger, C2H2
SMART	SM00355	3.1E-4	24	48	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	26	48	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	2.2E-7	51	78	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	9.265	54	83	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.053	54	78	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	56	79	IPR007087	Zinc finger, C2H2
SuperFamily	SSF57667	2.33E-5	147	175	No hit	No description
Gene3D	G3DSA:3.30.160.60	3.8E-9	150	175	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	8.954	152	185	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.016	152	177	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	154	177	IPR007087	Zinc finger, C2H2

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 297 aa Download sequence Send to blast
MLQKFLDSSK LKRHFLIHTG ERDFVCPHEG CGKAFSLDFN LRSHMKTHSQ ENYHICPHPE 60 CGKRYAHEYK LKNHIASHHE KHLLTSIFVN KVLFVWFTLA KTKCTALQCW IATRNMNPTP 120 EVVKYTTPPE RTPKNAKTPS VVYGSASSDR PYICPYEGCE KDYIHEYKLK LHLRREHPGH 180 IGDENAENGP PNADNELDEA SDQDAYGGKR VNGKSQKQSR SKPNLKMPPG KIRQRKGSSP 240 SPATLNVVKK PWTIKDETCE EEEDSEETEE EDRDNAEDGW RYGGNEDDDE ETEDED*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1ubd_C	1e-21	3	78	42	117	PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Dual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269\|PubMed:22508367, ECO:0000269\|PubMed:24451981, ECO:0000269\|PubMed:26961720}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	SapurV1A.0618s0030.1.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269\|PubMed:26961720}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	EF148507	1e-155	EF148507.1 Populus trichocarpa x Populus deltoides clone WS0131_N16 unknown mRNA.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006385011.1	1e-152	zinc finger transcription factor YY1
Swissprot	Q2V3L3	7e-92	YY1_ARATH; Zinc finger transcription factor YY1
TrEMBL	A0A2K2AYI3	1e-152	A0A2K2AYI3_POPTR; Uncharacterized protein
STRING	POPTR_0004s23050.1	1e-152	(Populus trichocarpa)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF5649	33	54

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT4G06634.2	1e-90	C2H2 family protein

Link Out ? help Back to Top
Phytozome	SapurV1A.0618s0030.1.p

Publications ? help Back to Top
Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4. DNA Res., 2001. 8(6): p. 285-90 [PMID:11853315] Li T,Wu XY,Li H,Song JH,Liu JY A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network. Mol Plant, 2016. 9(5): p. 650-661 [PMID:26961720] Wu XY,Li T A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response. Front Plant Sci, 2017. 8: p. 323 [PMID:28348572]