PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia

Family

HD-ZIP

Protein Properties

Length: 240aa MW: 27385.2 Da PI: 4.3407

Description

HD-ZIP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
SMil_00026667-RA_Salv	genome	NDCTCM	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	60.1	3.4e-19	52	105	3	56
--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS Homeobox 3 kRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56 k+++++ +q+++Le+ Fe ++++ e++ +LA++lgL+ rqV vWFqNrRa++k SMil_00026667-RA_Salv 52 KKRRLSVDQVKALEKNFEVENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWK 105 566899***********************************************9 PP
2	HD-ZIP_I/II	130	9.2e-42	51	142	1	92
HD-ZIP_I/II 1 ekkrrlskeqvklLEesFeeeekLeperKvelareLglqprqvavWFqnrRARtktkqlEkdyeaLkraydalkeenerLekeveeLr 88 ekkrrls +qvk+LE++Fe e+kLeperKv+la+eLglqprqvavWFqnrRAR+ktkqlE+dy Lk++yd lk + erL++++e+L SMil_00026667-RA_Salv 51 EKKRRLSVDQVKALEKNFEVENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWKTKQLERDYGGLKASYDGLKLNFERLQRDNESLL 138 69*************************************************************************************9 PP HD-ZIP_I/II 89 eelk 92 +el+ SMil_00026667-RA_Salv 139 KELN 142 9885 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF46689	3.68E-19	45	109	IPR009057	Homeodomain-like
PROSITE profile	PS50071	17.443	47	107	IPR001356	Homeobox domain
SMART	SM00389	6.3E-18	50	111	IPR001356	Homeobox domain
Pfam	PF00046	2.2E-16	52	105	IPR001356	Homeobox domain
CDD	cd00086	5.71E-16	52	108	No hit	No description
Gene3D	G3DSA:1.10.10.60	3.7E-20	54	113	IPR009057	Homeodomain-like
PRINTS	PR00031	5.7E-6	78	87	IPR000047	Helix-turn-helix motif
PROSITE pattern	PS00027	0	82	105	IPR017970	Homeobox, conserved site
PRINTS	PR00031	5.7E-6	87	103	IPR000047	Helix-turn-helix motif
Pfam	PF02183	1.4E-14	107	142	IPR003106	Leucine zipper, homeobox-associated

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009414	Biological Process	response to water deprivation
GO:0009788	Biological Process	negative regulation of abscisic acid-activated signaling pathway
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 240 aa Download sequence Send to blast
MKRLSNSDSL GGLMSICPNA TEEESNNPMY AREFQTMLEG LEEEESGHVS EKKRRLSVDQ 60 VKALEKNFEV ENKLEPERKV KLAQELGLQP RQVAVWFQNR RARWKTKQLE RDYGGLKASY 120 DGLKLNFERL QRDNESLLKE LNGDDEEKTR LESEIGGAEA EMENPEGGKK EEASWPKFGD 180 GSSDSDSSAI LNEENIGFQL GAPQLVKIEE HNFFGEESCS TLFSDDQPPS LPWYCNDQWD

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	99	107	RRARWKTKQ

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that may act as growth regulators in response to water deficit. Interacts with the core sequence 5'-CAATTATTA-3' of promoters in response to ABA and in an ABI1-dependent manner. Involved in the negative regulation of the ABA signaling pathway. {ECO:0000269\|PubMed:10527431, ECO:0000269\|PubMed:12065416}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00271	DAP	Transfer from AT2G22430	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By water deficit, by abscisic acid (ABA) and by salt stress. Self expression regulation. {ECO:0000269\|PubMed:10527431, ECO:0000269\|PubMed:12065416, ECO:0000269\|PubMed:16055682}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011097532.1	1e-104	homeobox-leucine zipper protein ATHB-6
Swissprot	P46668	3e-70	ATHB6_ARATH; Homeobox-leucine zipper protein ATHB-6
TrEMBL	A0A4D9AYZ9	1e-104	A0A4D9AYZ9_SALSN; Homeobox-leucine zipper protein
STRING	Migut.L00161.1.p	1e-101	(Erythranthe guttata)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA2718	24	53

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G22430.1	1e-71	homeobox protein 6

Publications ? help Back to Top
Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Song L, et al. A transcription factor hierarchy defines an environmental stress response network. Science, 2017. [PMID:27811239]