PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00019750-RA_Salv
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family HD-ZIP
Protein Properties Length: 719aa    MW: 79090.8 Da    PI: 6.8384
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00019750-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox629.3e-202277156
                           TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
               Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                           +++ +++t++q+++Le++F+++ +p++++r +L+++lgL  rq+k+WFqNrR+++k
  SMil_00019750-RA_Salv 22 KKRYHRHTAHQIQRLESMFKECAHPDEKTRNQLSRELGLHPRQIKFWFQNRRTQMK 77
                           678899***********************************************998 PP
2START161.18.2e-512234502206
                            HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S.. CS
                  START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetla.. 77 
                            +a +a++el+++ + +e +W ks+    e +n + + + f++ ++       ++ea+r sgvv+m+   lv  ++d++ +W e ++  
  SMil_00019750-RA_Salv 223 IAASAMDELIRLLQGNEMLWIKSAsdgrEVLNLESYERAFPRPNShlknpsVRTEASRSSGVVIMNDLALVDMFVDSS-KWMELFPai 309
                            67899*******************77776677777777776666699***99**************************.*******99 PP

                            ..EEEEEEEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--...-TTSEE-EESSEEEEE CS
                  START  78 ..kaetlevissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppe..sssvvRaellpSgili 154
                              +  t+evissg      galqlm+ elq+ls lvp R+ +f+R+ +q +ag+w+ivdvS d +++ ++  sss+ +a++lpSg+li
  SMil_00019750-RA_Salv 310 vsRERTIEVISSGmlgshsGALQLMYGELQVLSALVPtRKLYFLRFVQQIEAGSWAIVDVSYDIPNQDTQfsSSSSCKAHKLPSGCLI 397
                            9999***********************************************************999999999**************** PP

                            EEECTCEEEEEEEE-EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
                  START 155 epksnghskvtwvehvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                            ++++ng+skvtw+eh++++++   h l+r l++sgla+ga +w+a lqr ce+
  SMil_00019750-RA_Salv 398 QKMPNGYSKVTWIEHWEVEDKAAvHRLYRDLIHSGLAFGAERWLANLQRMCER 450
                            ******************988766***************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466898.77E-20779IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.601.9E-22981IPR009057Homeodomain-like
PROSITE profilePS5007117.411979IPR001356Homeobox domain
SMARTSM003896.9E-192083IPR001356Homeobox domain
CDDcd000861.95E-182180No hitNo description
PfamPF000462.8E-172277IPR001356Homeobox domain
PROSITE patternPS0002705477IPR017970Homeobox, conserved site
PROSITE profilePS5084846.117213453IPR002913START domain
SuperFamilySSF559614.55E-30215451No hitNo description
CDDcd088751.66E-110217449No hitNo description
SMARTSM002341.1E-40222450IPR002913START domain
PfamPF018521.2E-42223450IPR002913START domain
Gene3DG3DSA:3.30.530.201.6E-4320450IPR023393START-like domain
SuperFamilySSF559618.49E-18471711No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 719 aa     Download sequence    Send to blast
MEFSGGGGSS GGDPHDASER RKKRYHRHTA HQIQRLESMF KECAHPDEKT RNQLSRELGL  60
HPRQIKFWFQ NRRTQMKAQH ERADNCTLRA DNDRIRCENI AMREALRNVI CPSCGGPPVT  120
EDSYFDEQKL RMENAQLKEE LDRVSSIAAK YIGRPISQLP PVQPIHVSSL DLSMASFGGH  180
HGMPCPSLDL DLLPGSSLGM APSSLAFPPM SISDVDKSLM ADIAASAMDE LIRLLQGNEM  240
LWIKSASDGR EVLNLESYER AFPRPNSHLK NPSVRTEASR SSGVVIMNDL ALVDMFVDSS  300
KWMELFPAIV SRERTIEVIS SGMLGSHSGA LQLMYGELQV LSALVPTRKL YFLRFVQQIE  360
AGSWAIVDVS YDIPNQDTQF SSSSSCKAHK LPSGCLIQKM PNGYSKVTWI EHWEVEDKAA  420
VHRLYRDLIH SGLAFGAERW LANLQRMCER IACLMVAGNS NPERIGGIPS PEGTRSMMKL  480
AQRMVNNLCA SINPWSGQHL TSLLGSNELE VRATLHRSAD PGQPNRMVLS AAATIWLPVS  540
PHNVFNFFRD ERTRPQWDVL SNQNPVQEVA HIANGSHPGN CISVLRALNT SQNNMLILQE  600
SCIDSSGSLV VYCPVDLPSI NIAMSGDDTS FIPLLPSGFT ISPDGSATPD HFPGDGASTS  660
SNVDAAARSS AGSLVTVVFQ ILVSNMPTAR ISPETVNTVN NLIGNTVHQI KAAMNCSTS
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011072039.10.0homeobox-leucine zipper protein HDG11
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A4D8YQW40.0A0A4D8YQW4_SALSN; Homeobox-leucine zipper protein
STRINGMigut.O00242.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA24902351
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]