PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

SMil_00015103-RA_Salv

Organism

Salvia miltiorrhiza

Taxonomic ID

226208

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia

Family

CAMTA

Protein Properties

Length: 1104aa MW: 124156 Da PI: 5.9779

Description

CAMTA family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
SMil_00015103-RA_Salv	genome	NDCTCM	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	CG-1	176.5	3.5e-55	20	142	2	118
CG-1 2 lkekkrwlkneeiaaiLenfekheltlelktrpksgsliLynrkkvryfrkDGyswkkkkdgktvrEdhekLKvgg......vevlyc 83 l+ ++rwl++ ei++iL+n++k++++ e+++rp++gsl+L++rk++ryfrkDG++w+kkkdgktv+E+he+LK+ v+vl+c SMil_00015103-RA_Salv 20 LEAQHRWLRPAEICEILQNYKKFRIAPEPPNRPPNGSLFLFDRKVLRYFRKDGHNWRKKKDGKTVKEAHERLKMAKslqagsVDVLHC 107 5679*******************************************************************988899999** PP CG-1 84 yYahseenptfqrrcywlLeeelekivlvhylevk 118 yYah+e+n++fqrr+yw+Leeel++ivlvhy+evk SMil_00015103-RA_Salv 108 YYAHGEDNENFQRRSYWMLEEELSHIVLVHYREVK 142 ******************************986 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51437	83.297	15	147	IPR005559	CG-1 DNA-binding domain
SMART	SM01076	2.1E-77	18	142	IPR005559	CG-1 DNA-binding domain
Pfam	PF03859	1.7E-47	21	140	IPR005559	CG-1 DNA-binding domain
SuperFamily	SSF81296	4.8E-16	537	622	IPR014756	Immunoglobulin E-set
Pfam	PF01833	3.4E-5	537	614	IPR002909	IPT domain
SuperFamily	SSF48403	4.04E-19	704	820	IPR020683	Ankyrin repeat-containing domain
CDD	cd00204	3.35E-16	706	818	No hit	No description
Gene3D	G3DSA:1.25.40.20	9.6E-19	706	822	IPR020683	Ankyrin repeat-containing domain
PROSITE profile	PS50297	19.492	709	830	IPR020683	Ankyrin repeat-containing domain
Pfam	PF12796	1.8E-9	731	821	IPR020683	Ankyrin repeat-containing domain
PROSITE profile	PS50088	9.805	759	791	IPR002110	Ankyrin repeat
SMART	SM00248	4.4E-4	759	788	IPR002110	Ankyrin repeat
SMART	SM00248	73	798	827	IPR002110	Ankyrin repeat
SuperFamily	SSF52540	4.78E-8	923	981	IPR027417	P-loop containing nucleoside triphosphate hydrolase
SMART	SM00015	23	930	952	IPR000048	IQ motif, EF-hand binding site
PROSITE profile	PS50096	7.199	932	960	IPR000048	IQ motif, EF-hand binding site
Pfam	PF00612	0.08	932	951	IPR000048	IQ motif, EF-hand binding site
SMART	SM00015	0.0044	953	975	IPR000048	IQ motif, EF-hand binding site
PROSITE profile	PS50096	9.706	954	978	IPR000048	IQ motif, EF-hand binding site
Pfam	PF00612	1.1E-4	958	975	IPR000048	IQ motif, EF-hand binding site

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009409	Biological Process	response to cold
GO:0010150	Biological Process	leaf senescence
GO:0042742	Biological Process	defense response to bacterium
GO:0050832	Biological Process	defense response to fungus
GO:0005634	Cellular Component	nucleus
GO:0003677	Molecular Function	DNA binding
GO:0005516	Molecular Function	calmodulin binding

Sequence ? help Back to Top
Protein Sequence Length: 1104 aa Download sequence Send to blast
MAESRRYALN AQLDIEQILL EAQHRWLRPA EICEILQNYK KFRIAPEPPN RPPNGSLFLF 60 DRKVLRYFRK DGHNWRKKKD GKTVKEAHER LKMAKSLQAG SVDVLHCYYA HGEDNENFQR 120 RSYWMLEEEL SHIVLVHYRE VKGNRTNYNR IRDADSIPAS RQSEDVSNSE VDSSAASRFQ 180 SYDYQRASPI TDTTSHNSTL ASDLEDAESA YRHQASPGFQ TIHDLQSPIV PTTDAGPIPY 240 HPIPVSSNYQ GQSSAIPGMS FGPITQGEEN RTPLDNGLTY DFQQDIGFPS WGNVAESSSA 300 SYQSVDFQLS LPSTQSSAMS MMPGQDNELL DHVFTSAFRK KQEFRNHSDS LGEWQATDRG 360 SLHMSEWSID QKPDGNLNIG QNTNQPPLVY HPGTKLNDAS EVQLSDSLAL HNSYLTDQHR 420 QHLENDLQRQ ALNSGESSLK SEPSRNLNAG DKANYPSLRQ PLLDGVMREG LKKLDSFDRW 480 ISKELDDVTE STMQPGSGVY WETVGGGDGD DSGISTQVPS DNYVLGPSLS QDQLFSIIDF 540 SPNWVYSGSE IKVLVTGRFL RNREVESYKW ACMFGELEVP AEIVGDGVLR CLTPLHEPGR 600 VPFYITCCNR LACSEVREFE FRTSSVEDVD SDETRLYMRF GKLLSLGSDT PQISLQSIDD 660 ETSQLFSKIS ALLKDDTEWE QMLSFTKKDD NVKDQLLQKL LKEKLHNWLI QKIAEGGKGP 720 NVLDAEGLGV LHFAAALGYD WAIPPTIAAG VSVNFRDVNG WTALHWAAYY GREHTVAFLI 780 SIGALPGALT DPTPIHPSGE TPADLAASNG HKGIAGYLAE SSLSSHLSSL DLKDSRQSDS 840 REKVVETVAE RIATPVGAGD LPHGLSMKDS LAAVRNATQA AARIHQVFRV QSFQRKQLKE 900 YGDSEFGISD ERALSLLALK SKKAGQHDEP VHSAAVRIQN KFRSWKGRKD FLLIRQQIIK 960 IQAHVRGHQV RKNYKKIIWS VGILDKVILR WRRKGRGLSG FRPEASVASS SMVEAETKED 1020 DYDFLKAGRK QTEERLHKAL ARVKSMVQYP EARDQYRRLL NVVSEMQEKK AAQERMLNNP 1080 EVDFDEDLID FEALLEDDSF MPIE

Sequence ? help Back to Top

Protein Sequence Length: 1104 aa Download sequence Send to blast

MAESRRYALN AQLDIEQILL EAQHRWLRPA EICEILQNYK KFRIAPEPPN RPPNGSLFLF  60
DRKVLRYFRK DGHNWRKKKD GKTVKEAHER LKMAKSLQAG SVDVLHCYYA HGEDNENFQR  120
RSYWMLEEEL SHIVLVHYRE VKGNRTNYNR IRDADSIPAS RQSEDVSNSE VDSSAASRFQ  180
SYDYQRASPI TDTTSHNSTL ASDLEDAESA YRHQASPGFQ TIHDLQSPIV PTTDAGPIPY  240
HPIPVSSNYQ GQSSAIPGMS FGPITQGEEN RTPLDNGLTY DFQQDIGFPS WGNVAESSSA  300
SYQSVDFQLS LPSTQSSAMS MMPGQDNELL DHVFTSAFRK KQEFRNHSDS LGEWQATDRG  360
SLHMSEWSID QKPDGNLNIG QNTNQPPLVY HPGTKLNDAS EVQLSDSLAL HNSYLTDQHR  420
QHLENDLQRQ ALNSGESSLK SEPSRNLNAG DKANYPSLRQ PLLDGVMREG LKKLDSFDRW  480
ISKELDDVTE STMQPGSGVY WETVGGGDGD DSGISTQVPS DNYVLGPSLS QDQLFSIIDF  540
SPNWVYSGSE IKVLVTGRFL RNREVESYKW ACMFGELEVP AEIVGDGVLR CLTPLHEPGR  600
VPFYITCCNR LACSEVREFE FRTSSVEDVD SDETRLYMRF GKLLSLGSDT PQISLQSIDD  660
ETSQLFSKIS ALLKDDTEWE QMLSFTKKDD NVKDQLLQKL LKEKLHNWLI QKIAEGGKGP  720
NVLDAEGLGV LHFAAALGYD WAIPPTIAAG VSVNFRDVNG WTALHWAAYY GREHTVAFLI  780
SIGALPGALT DPTPIHPSGE TPADLAASNG HKGIAGYLAE SSLSSHLSSL DLKDSRQSDS  840
REKVVETVAE RIATPVGAGD LPHGLSMKDS LAAVRNATQA AARIHQVFRV QSFQRKQLKE  900
YGDSEFGISD ERALSLLALK SKKAGQHDEP VHSAAVRIQN KFRSWKGRKD FLLIRQQIIK  960
IQAHVRGHQV RKNYKKIIWS VGILDKVILR WRRKGRGLSG FRPEASVASS SMVEAETKED  1020
DYDFLKAGRK QTEERLHKAL ARVKSMVQYP EARDQYRRLL NVVSEMQEKK AAQERMLNNP  1080
EVDFDEDLID FEALLEDDSF MPIE

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4hb5_A	3e-11	710	818	20	122	Engineered Protein
4hb5_B	3e-11	710	818	20	122	Engineered Protein
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds to the DNA consensus sequence 5'-[ACG]CGCG[GTC]-3'. Binds calmodulin in a calcium-dependent manner in vitro (PubMed:12218065). Regulates transcriptional activity in response to calcium signals (Probable). Involved in freezing tolerance in association with CAMTA1 and CAMTA2 (PubMed:23581962). Required for the cold-induced expression of DREB1B/CBF1, DREB1C/CBF2, ZAT12 and GOLS3 (PubMed:19270186). Involved in response to cold. Contributes together with CAMTA5 to the positive regulation of the cold-induced expression of DREB1A/CBF3, DREB1B/CBF1 and DREB1C/CBF2 (PubMed:28351986). Involved together with CAMTA2 and CAMTA4 in the positive regulation of a general stress response (GSR) (PubMed:25039701). Involved in the regulation of GSR amplitude downstream of MEKK1 (PubMed:25157030). Involved in the regulation of a set of genes involved in defense responses against pathogens (PubMed:18298954). Involved in the regulation of both basal resistance and systemic acquired resistance (SAR) (PubMed:21900483). Acts as negative regulator of plant immunity (PubMed:19122675, PubMed:21900483, PubMed:22345509, PubMed:28407487). Binds to the promoter of the defense-related gene EDS1 and represses its expression (PubMed:19122675). Binds to the promoter of the defense-related gene NDR1 and represses its expression (PubMed:22345509). Involved in defense against insects (PubMed:23072934, PubMed:22371088). Required for tolerance to the generalist herbivore Trichoplusia ni, and contributes to the positive regulation of genes associated with glucosinolate metabolism (PubMed:23072934). Required for tolerance to Bradysia impatiens larvae. Mediates herbivore-induced wound response (PubMed:22371088). Required for wound-induced jasmonate accumulation (PubMed:23072934, PubMed:22371088). Involved in the regulation of ethylene-induced senescence by binding to the promoter of the senescence-inducer gene EIN3 and repressing its expression (PubMed:22345509). {ECO:0000269\|PubMed:12218065, ECO:0000269\|PubMed:18298954, ECO:0000269\|PubMed:19122675, ECO:0000269\|PubMed:19270186, ECO:0000269\|PubMed:21900483, ECO:0000269\|PubMed:22345509, ECO:0000269\|PubMed:22371088, ECO:0000269\|PubMed:23072934, ECO:0000269\|PubMed:23581962, ECO:0000269\|PubMed:25039701, ECO:0000269\|PubMed:25157030, ECO:0000269\|PubMed:28351986, ECO:0000269\|PubMed:28407487, ECO:0000305\|PubMed:11925432}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00042	PBM	Transfer from AT2G22300	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By heat shock, UVB, salt, wounding, ethylene and methyl jasmonate (PubMed:11162426, PubMed:12218065). Induced by infection with the fungal pathogen Golovinomyces cichoracearum (powdery mildew) and the bacterial pathogen Pseudomonas syringae pv tomato strain DC3000 (PubMed:22345509). {ECO:0000269\|PubMed:11162426, ECO:0000269\|PubMed:12218065, ECO:0000269\|PubMed:22345509}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011097567.1	0.0	calmodulin-binding transcription activator 1-like
Refseq	XP_011097568.1	0.0	calmodulin-binding transcription activator 1-like
Swissprot	Q8GSA7	0.0	CMTA3_ARATH; Calmodulin-binding transcription activator 3
TrEMBL	A0A4D8Z707	0.0	A0A4D8Z707_SALSN; Uncharacterized protein
STRING	XP_009613615.1	0.0	(Nicotiana tomentosiformis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA2230	21	46

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G22300.2	0.0	signal responsive 1

Publications ? help Back to Top
Zhang L,Du L,Shen C,Yang Y,Poovaiah BW Regulation of plant immunity through ubiquitin-mediated modulation of Ca(2+) -calmodulin-AtSR1/CAMTA3 signaling. Plant J., 2014. 78(2): p. 269-81 [PMID:24528504] Benn G, et al. A key general stress response motif is regulated non-uniformly by CAMTA transcription factors. Plant J., 2014. 80(1): p. 82-92 [PMID:25039701] Rahman H,Yang J,Xu YP,Munyampundu JP,Cai XZ Phylogeny of Plant CAMTAs and Role of AtCAMTAs in Nonhost Resistance to Xanthomonas oryzae pv. oryzae. Front Plant Sci, 2016. 7: p. 177 [PMID:26973658] Benn G, et al. Plastidial metabolite MEcPP induces a transcriptionally centered stress-response hub via the transcription factor CAMTA3. Proc. Natl. Acad. Sci. U.S.A., 2016. 113(31): p. 8855-60 [PMID:27432993] Kidokoro S, et al. Different Cold-Signaling Pathways Function in the Responses to Rapid and Gradual Decreases in Temperature. Plant Cell, 2017. 29(4): p. 760-774 [PMID:28351986] Lolle S, et al. Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles. Cell Host Microbe, 2017. 21(4): p. 518-529.e4 [PMID:28407487] Kim YS, et al. CAMTA-Mediated Regulation of Salicylic Acid Immunity Pathway Genes in Arabidopsis Exposed to Low Temperature and Pathogen Infection. Plant Cell, 2017. 29(10): p. 2465-2477 [PMID:28982964] Jacob F, et al. A dominant-interfering camta3 mutation compromises primary transcriptional outputs mediated by both cell surface and intracellular immune receptors in Arabidopsis thaliana. New Phytol., 2018. 217(4): p. 1667-1680 [PMID:29226970]