PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia

Family

E2F/DP

Protein Properties

Length: 588aa MW: 65266.1 Da PI: 5.7072

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
SMil_00013321-RA_Salv	genome	NDCTCM	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	82.6	3.2e-26	217	282	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL llt+kf++l++++e+g+++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg SMil_00013321-RA_Salv 217 RYDSSLSLLTKKFIALIKHAEDGELDLNKAADTL---QV--QKRRIYDITNVLEGIGLIEKKLKNRIHWKG 282 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	8.9E-28	215	284	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	1.0E-33	217	282	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.36E-16	217	280	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	4.1E-24	219	282	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	6.8E-32	297	399	No hit	No description
Pfam	PF16421	1.1E-31	298	397	IPR032198	E2F transcription factor, CC-MB domain
CDD	cd14660	8.22E-46	298	399	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 588 aa Download sequence Send to blast
LPSTSIRTKI PSLPSSFSTP PTQHAHTTLS SIKTLISPLY LSYYTPPPPS PILIFTIRFD 60 FTLLMAARAT PSRDAAATPP AAPSNVQILH HQQTPPPTIR RHLPFASMKP PFVSPDDYHR 120 FSTPSRAAPD HLSEAVVIKS SPFKRKNGYQ NNEVESSEWT ASPVYSDIAN SPFRTPVSAK 180 GGRANSRSKV TKNNRSLPST PISNADAPSP LTPASCRYDS SLSLLTKKFI ALIKHAEDGE 240 LDLNKAADTL QVQKRRIYDI TNVLEGIGLI EKKLKNRIHW KGLDSSRPGD MDKDGTLLHA 300 EIENLSMEER SLDERIRQMQ ERLRDLSEDD HNQRWLFVTE DDIKNLPCFQ NETLIAIKAP 360 HGTTLEVPDP DEAVDYPQRR YRIILRSTMG AIDVYLVSQF EEKFEEANGV EDSANFPVAS 420 SSGAHENLAI EKSSMAHGPP EVETLTQDSH GLDTVYDSPQ EYAGGMTKII PSNIDVSEND 480 ADYWLLSDAA GISMTDLWKT DSGVEWNDVN MLHEELEMAA ISTPRALIPS SVDSDVHPVD 540 NVQPRRGCAR ENRYGRALGA KWLQYTVGES PDLGHTSQVN NQSILPFS

Sequence ? help Back to Top

Protein Sequence Length: 588 aa Download sequence Send to blast

LPSTSIRTKI PSLPSSFSTP PTQHAHTTLS SIKTLISPLY LSYYTPPPPS PILIFTIRFD  60
FTLLMAARAT PSRDAAATPP AAPSNVQILH HQQTPPPTIR RHLPFASMKP PFVSPDDYHR  120
FSTPSRAAPD HLSEAVVIKS SPFKRKNGYQ NNEVESSEWT ASPVYSDIAN SPFRTPVSAK  180
GGRANSRSKV TKNNRSLPST PISNADAPSP LTPASCRYDS SLSLLTKKFI ALIKHAEDGE  240
LDLNKAADTL QVQKRRIYDI TNVLEGIGLI EKKLKNRIHW KGLDSSRPGD MDKDGTLLHA  300
EIENLSMEER SLDERIRQMQ ERLRDLSEDD HNQRWLFVTE DDIKNLPCFQ NETLIAIKAP  360
HGTTLEVPDP DEAVDYPQRR YRIILRSTMG AIDVYLVSQF EEKFEEANGV EDSANFPVAS  420
SSGAHENLAI EKSSMAHGPP EVETLTQDSH GLDTVYDSPQ EYAGGMTKII PSNIDVSEND  480
ADYWLLSDAA GISMTDLWKT DSGVEWNDVN MLHEELEMAA ISTPRALIPS SVDSDVHPVD  540
NVQPRRGCAR ENRYGRALGA KWLQYTVGES PDLGHTSQVN NQSILPFS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	2e-22	210	283	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011094221.1	0.0	transcription factor E2FA
Swissprot	Q9FNY0	1e-148	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A4D9AXF6	0.0	A0A4D9AXF6_SALSN; Uncharacterized protein
STRING	Migut.J00719.1.p	0.0	(Erythranthe guttata)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-152	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]