PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia

Family

HB-other

Protein Properties

Length: 289aa MW: 33629.9 Da PI: 5.5945

Description

HB-other family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
SMil_00012017-RA_Salv	genome	NDCTCM	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	28.2	3.2e-09	231	265	21	55
HSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHH CS Homeobox 21 knrypsaeereeLAkklgLterqVkvWFqNrRake 55 k +yp+++++ LA+ +gL+++q+ +WF N+R ++ SMil_00012017-RA_Salv 231 KWPYPTEADKIALAEMTGLDQKQINNWFINQRKRH 265 569*****************************885 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM01255	1.6E-20	63	107	IPR005540	KNOX1
Pfam	PF03790	3.4E-21	65	105	IPR005540	KNOX1
SMART	SM01256	1.8E-21	109	160	IPR005541	KNOX2
Pfam	PF03791	5.1E-20	114	159	IPR005541	KNOX2
PROSITE profile	PS50071	12.503	205	268	IPR001356	Homeobox domain
SuperFamily	SSF46689	3.98E-18	206	276	IPR009057	Homeodomain-like
SMART	SM00389	3.6E-11	207	272	IPR001356	Homeobox domain
Gene3D	G3DSA:1.10.10.60	1.5E-26	210	268	IPR009057	Homeodomain-like
CDD	cd00086	3.02E-11	219	268	No hit	No description
Pfam	PF05920	6.9E-17	225	264	IPR008422	Homeobox KN domain
PROSITE pattern	PS00027	0	243	266	IPR017970	Homeobox, conserved site

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010073	Biological Process	meristem maintenance
GO:0005634	Cellular Component	nucleus
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 289 aa Download sequence Send to blast
LMSPENMMMA EEYNQYHYHS PINSGDKYHH RIPMLGSDEL GFQSSVVSHD SASVNVQNQR 60 DEDEMKAKIA SHPSYSKLLD AYIDCQKVGA PPEIVSVLDE MRRENPDTVS VCTELDPQLD 120 EFMETYRHIL VKYKSDLSRP FDEATSFLNE IQTQLLNLCN DEAAVWSDEE LMEQQDAETK 180 REDRLLKEKL VRMYGSHISS LKLEFSKKKK KGKLPKEGRQ SLLAWWNLHS KWPYPTEADK 240 IALAEMTGLD QKQINNWFIN QRKRHWKSPD NMFAPDNLSP KPNFVPQDH

Functional Description ? help Back to Top
Source	Description
UniProt	Plays a role in meristem function. Contributes to the shoot apical meristem (SAM) maintenance and organ separation by controlling boundary establishment in embryo in a CUC1, CUC2 and STM-dependent manner. Involved in maintaining cells in an undifferentiated, meristematic state. Probably binds to the DNA sequence 5'-TGAC-3'. {ECO:0000269\|PubMed:16798887}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Seems to be repressed by AS2 and AS1 but induced by STM, CUC1 and CUC2. {ECO:0000269\|PubMed:11311158, ECO:0000269\|PubMed:16798887}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011071110.1	1e-128	homeobox protein knotted-1-like 6 isoform X1
Swissprot	Q84JS6	7e-96	KNAT6_ARATH; Homeobox protein knotted-1-like 6
TrEMBL	A0A4D9BPY1	1e-137	A0A4D9BPY1_SALSN; Uncharacterized protein
STRING	VIT_01s0127g00210.t01	1e-106	(Vitis vinifera)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA753	24	80

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G23380.1	6e-89	KNOTTED1-like homeobox gene 6

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Khan M, et al. Repression of Lateral Organ Boundary Genes by PENNYWISE and POUND-FOOLISH Is Essential for Meristem Maintenance and Flowering in Arabidopsis. Plant Physiol., 2015. 169(3): p. 2166-86 [PMID:26417006]