PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00004784-RA_Salv
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family bHLH
Protein Properties Length: 443aa    MW: 48203.1 Da    PI: 8.2257
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00004784-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH39.69.5e-13268313454
                            HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS
                    HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksL 54 
                            +h e+Er+RR+++N++f  Lr ++P+       K++Ka+ L  A+ YI++L
  SMil_00004784-RA_Salv 268 NHVEAERQRREKLNQRFYALRAVVPNV-----SKMDKASLLGDAIAYINEL 313
                            799***********************6.....5***************998 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PfamPF142157.6E-18166IPR025610Transcription factor MYC/MYB N-terminal
PROSITE profilePS5088817.111264313IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474595.89E-18265333IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000839.23E-15267318No hitNo description
PfamPF000103.3E-10268313IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.106.9E-18268334IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.4E-16270319IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006952Biological Processdefense response
GO:0009718Biological Processanthocyanin-containing compound biosynthetic process
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043425Molecular FunctionbHLH transcription factor binding
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 443 aa     Download sequence    Send to blast
MTQNFVNGSG LPGQALYTSS PVWVTGPERL ASSHCDRARQ AQGFGLQTLV CIPSPNGVVE  60
LGSTELLVLA GDRPGGAVAH GAVFLRRGCQ GFVINNPNQG SSIPSSITSN QSHLVKENPN  120
STTMNENQNL GYVSRELKFS EFGFDGSSNP KNGGGFRPES GEILNFGESS KINSANGNVN  180
NLFGIENENS NNRNKVKKRS PTSRGSNEEG MLSFSSAAMK ADGGIDSDHS DLEPSVVKEV  240
ECSTVVDPEK RPRKRGRKPA NGREEPLNHV EAERQRREKL NQRFYALRAV VPNVSKMDKA  300
SLLGDAIAYI NELKSKLQNV EIAKDDLRRQ LESYSKEGGG RHSVPAPPER ETKVSGSNAM  360
VDIDVDVKII GWDAMIRIQC SKNNHPAAKL MVALMELDLD VHHASVSVVN DLMIQQATVK  420
MEGRIFTQDQ LKLALISKVA ETR
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5gnj_A7e-34262341281Transcription factor MYC2
5gnj_B7e-34262341281Transcription factor MYC2
5gnj_E7e-34262341281Transcription factor MYC2
5gnj_F7e-34262341281Transcription factor MYC2
5gnj_G7e-34262341281Transcription factor MYC2
5gnj_I7e-34262341281Transcription factor MYC2
5gnj_M7e-34262341281Transcription factor MYC2
5gnj_N7e-34262341281Transcription factor MYC2
Search in ModeBase
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
1249257KRPRKRGRK
Functional Description ? help Back to Top
Source Description
UniProtTranscriptional activator that binds to the G-box motif (5'-AACGTG-3') found in the promoter of the jasmonate-induced gene LAPA1 (PubMed:15231736). Acts as negative regulator of blue light-mediated photomorphogenesis and positively regulates root growth (PubMed:24483714). Promotes growth in response to the phytohormones abscisic acid (ABA) and jasmonate (JA) (PubMed:24483714). Binds to the G-box motif (5'-CACGTG-3') of the RBCS-3A gene promoter (PubMed:24483714). Acts downstream of the jasmonate (JA) receptor to orchestrate JA-mediated activation of plant responses (PubMed:28733419). Positively regulates both wound-responsive and pathogen-responsive genes through MYC2-targeted transcription factors (MTFs) involved in early response to JA (PubMed:28733419). With JA2L forms a transcription module that regulates wounding-responsive genes (PubMed:28733419). With ERF.C3 forms a transcription module that regulates pathogen-responsive genes (PubMed:28733419). Plays a critical role in orchestrating JA-mediated defense gene expression during Botrytis cinerea infection (PubMed:28733419). Regulates negatively defense responses to root-knot nematodes, potentially by mediating crosstalk among the hormones strigolactones, abscisic acid (ABA) and jasmonate (JA) (PubMed:30576511). Regulates the termination of JA-mediated defense responses by specifically binding the G-box (5'-CACATG-3') motifs in the promoters of MTB1, MTB2 and MTB3, which are transcription factors that negatively regulates JA signaling (PubMed:30610166). May be involved in JA-induced chilling tolerance, possibly by ameliorating the antioxidant enzyme system of fruit and increasing proline and lycopene levels (PubMed:29528226). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:24483714, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511, ECO:0000269|PubMed:30610166}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00086PBMTransfer from AT4G17880Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by methyl jasmonate (PubMed:15231736, PubMed:28733419). Induced by wounding (PubMed:15231736). Induced by infection with the fungal pathogen Botrytis cinerea (PubMed:28733419). Induced in fruit by storage in cold (PubMed:29528226). Induced by hydrogen peroxide and infection with root-knot nematodes (PubMed:30576511). {ECO:0000269|PubMed:15231736, ECO:0000269|PubMed:28733419, ECO:0000269|PubMed:29528226, ECO:0000269|PubMed:30576511}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKP2574760.0KP257476.1 Salvia miltiorrhiza clone 43 basic helix-loop-helix transcription factor mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011082365.10.0transcription factor MYC4-like
SwissprotA0A3Q7HRZ61e-177MYC2_SOLLC; Transcription factor MYC2
TrEMBLA0A0H3Y7I30.0A0A0H3Y7I3_SALMI; Basic helix-loop-helix transcription factor
STRINGXP_009609942.10.0(Nicotiana tomentosiformis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA33002449
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G32640.11e-105bHLH family protein
Publications ? help Back to Top
  1. Tomato Genome Consortium
    The tomato genome sequence provides insights into fleshy fruit evolution.
    Nature, 2012. 485(7400): p. 635-41
    [PMID:22660326]
  2. Gupta N,Prasad VB,Chattopadhyay S
    LeMYC2 acts as a negative regulator of blue light mediated photomorphogenic growth, and promotes the growth of adult tomato plants.
    BMC Plant Biol., 2014. 14: p. 38
    [PMID:24483714]
  3. Sun H,Fan HJ,Ling HQ
    Genome-wide identification and characterization of the bHLH gene family in tomato.
    BMC Genomics, 2015. 16: p. 9
    [PMID:25612924]
  4. Du M, et al.
    MYC2 Orchestrates a Hierarchical Transcriptional Cascade That Regulates Jasmonate-Mediated Plant Immunity in Tomato.
    Plant Cell, 2017. 29(8): p. 1883-1906
    [PMID:28733419]
  5. Min D, et al.
    SlMYC2 Involved in Methyl Jasmonate-Induced Tomato Fruit Chilling Tolerance.
    J. Agric. Food Chem., 2018. 66(12): p. 3110-3117
    [PMID:29528226]
  6. Xu X, et al.
    Strigolactones positively regulate defense against root-knot nematodes in tomato.
    J. Exp. Bot., 2019. 70(4): p. 1325-1337
    [PMID:30576511]
  7. Liu Y, et al.
    MYC2 Regulates the Termination of Jasmonate Signaling via an Autoregulatory Negative Feedback Loop.
    Plant Cell, 2019. 31(1): p. 106-127
    [PMID:30610166]