PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00003992-RA_Salv
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family bHLH
Protein Properties Length: 231aa    MW: 26201.3 Da    PI: 9.4636
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00003992-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH45.51.3e-1457108155
                            CHHHHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                    HLH   1 rrrahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                            +r++h ++Er+RR+++N+ ++ Lr+l+P+    +  + + a+i+  A+e++++Lq
  SMil_00003992-RA_Salv  57 QRMTHIAVERNRRKQMNEHLQILRSLMPTY---YVHRGDQASIVGAAIEFVRELQ 108
                            79***************************9...9********************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
CDDcd000831.73E-1155112No hitNo description
Gene3DG3DSA:4.10.280.105.4E-1455111IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PROSITE profilePS5088814.78656107IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamilySSF474596.02E-1856129IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000105.1E-1257108IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.4E-1062113IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 231 aa     Download sequence    Send to blast
MVDCMLNNPP SPPPPSSSLA DTMQLAIDEA KTSVEGKGKN KRKRDKTNKS IEEVEKQRMT  60
HIAVERNRRK QMNEHLQILR SLMPTYYVHR GDQASIVGAA IEFVRELQQL LQCLESVKRH  120
QHHQPQMILP PTLDQTAESK SYLADVEVKL SGLFGLIKIL SRRRRGQLIK YIAAVEHLHL  180
HILQTDITTI QQDVVCSFTV KMSREAMLTA EDMANSIQQI LNSLHASSSM S
Nucleic Localization Signal ? help Back to Top
NLS
No. Start End Sequence
15768RMTHIAVERNRR
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator (PubMed:17088607, PubMed:17183265, PubMed:17183267). Together with MYB88 and MYB124, ensures that stomata contain just two guard cells (GCs) by enforcing a single symmetric precursor cell division before stomatal maturity (PubMed:24571519). Together with SPCH and MUTE, regulates the stomata formation. Required to promote differentiation and morphogenesis of stomatal guard cells and to halt proliferative divisions in their immediate precursors. Mediates the formation of stomata (PubMed:17088607, PubMed:17183265, PubMed:17183267). Prevents histone H3K27me3 marks and derepresses stem cell gene expression (PubMed:24654956). {ECO:0000269|PubMed:17088607, ECO:0000269|PubMed:17183265, ECO:0000269|PubMed:17183267, ECO:0000269|PubMed:24571519, ECO:0000269|PubMed:24654956}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Inhibited by low relative humidity (LRH) via epigenetic CG methylation, thus leading to a reduced stomatal index. {ECO:0000269|PubMed:22442411}.
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKP2574650.0KP257465.1 Salvia miltiorrhiza clone 32 basic helix-loop-helix transcription factor mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_027118093.11e-77transcription factor FAMA-like isoform X2
RefseqXP_027119013.11e-77transcription factor FAMA-like isoform X2
RefseqXP_027120772.11e-77transcription factor FAMA-like isoform X2
RefseqXP_027165026.12e-77transcription factor FAMA isoform X1
RefseqXP_027165028.12e-77transcription factor FAMA isoform X2
SwissprotQ56YJ82e-74FAMA_ARATH; Transcription factor FAMA
TrEMBLA0A0H3YC301e-170A0A0H3YC30_SALMI; Basic helix-loop-helix transcription factor
STRINGevm.model.supercontig_59.1326e-77(Carica papaya)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA46572341
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G24140.11e-76bHLH family protein
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Matos JL, et al.
    Irreversible fate commitment in the Arabidopsis stomatal lineage requires a FAMA and RETINOBLASTOMA-RELATED module.
    Elife, 2015.
    [PMID:25303364]
  3. Chen L, et al.
    NRPB3, the third largest subunit of RNA polymerase II, is essential for stomatal patterning and differentiation in Arabidopsis.
    Development, 2016. 143(9): p. 1600-11
    [PMID:26989174]
  4. Lee JH,Jung JH,Park CM
    Light Inhibits COP1-Mediated Degradation of ICE Transcription Factors to Induce Stomatal Development in Arabidopsis.
    Plant Cell, 2017. 29(11): p. 2817-2830
    [PMID:29070509]
  5. Han X, et al.
    Jasmonate Negatively Regulates Stomatal Development in Arabidopsis Cotyledons.
    Plant Physiol., 2018. 176(4): p. 2871-2885
    [PMID:29496884]
  6. Li X,Yang R,Chen H
    The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
    PLoS ONE, 2018. 13(3): p. e0193458
    [PMID:29513733]