PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID SMil_00003140-RA_Salv
Organism
Salvia miltiorrhiza
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Mentheae; Salvia
Family HD-ZIP
Protein Properties Length: 693aa    MW: 75906.8 Da    PI: 6.3134
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
SMil_00003140-RA_SalvgenomeNDCTCMView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox63.43.4e-202580156
                           TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
               Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                           +++ +++t++q+++Le++F+++++p++++r +L+++l+L  rq+k+WFqNrR+++k
  SMil_00003140-RA_Salv 25 KKRYHRHTAHQIQRLESMFKECPHPDEKTRNQLSRELNLHPRQIKFWFQNRRTQMK 80
                           688999***********************************************998 PP
2START124.51.3e-392234322206
                            HHHHHHHHHHHHHHHC-TT-EEEE......EXCCTTEEEEEEESSS........SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT- CS
                  START   2 laeeaaqelvkkalaeepgWvkss......esengdevlqkfeeskv.......dsgealrasgvvdmvlallveellddkeqWdetl 76 
                            +a  a++el+++ +++ep+W k          e +++v q++             ++ea+r+sgvv+m++  lv  ++d k +W e +
  SMil_00003140-RA_Salv 223 IAANAMDELIRLLQSNEPLWIKGGdgretlNLESYEKVFQSP----YshmknpnIRIEASRDSGVVIMNSLALVDMFMDAK-KWVELF 305
                            67889*****************99886555555556666655....134479999**************************.****** PP

                            S....EEEEEEEECTTEEEEEEEEXXTTXX-SSXEEEEEEEEEEE..TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECT CS
                  START  77 a....kaetlevissggalqlmvaelqalsplvpRdfvfvRyirq.lgagdwvivdvSvdseqkppesssvvRaellpSgiliepksn 159
                            +    +a+t+evissg  l  ++  lq+          ++++i + +++g+w++vdvS d++ +  + ss  +a++lpSg+li++++n
  SMil_00003140-RA_Salv 306 PtivsRAKTIEVISSGM-LGSQSGTLQL--------AAVLAQILSaDEQGSWAVVDVSYDVPHQDGQFSSPCKAQRLPSGCLIQEMPN 384
                            99999**********94.4444555555........3577777777**************998887788999**************** PP

                            CEEEEEEEE-EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
                  START 160 ghskvtwvehvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                            g+s+vtwveh++++++ p h l+r l++sgla+ga +w++tlqr ce+
  SMil_00003140-RA_Salv 385 GYSEVTWVEHWEVEEKAPiHRLYRDLIHSGLAFGAERWLSTLQRACER 432
                            **********************************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466891.8E-20882IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.603.2E-231184IPR009057Homeodomain-like
PROSITE profilePS5007117.3132282IPR001356Homeobox domain
SMARTSM003894.8E-192486IPR001356Homeobox domain
PfamPF000469.2E-182580IPR001356Homeobox domain
CDDcd000866.06E-192583No hitNo description
PROSITE patternPS0002705780IPR017970Homeobox, conserved site
PROSITE profilePS5084836.978213435IPR002913START domain
SuperFamilySSF559611.3E-26214433No hitNo description
CDDcd088751.10E-94217431No hitNo description
SMARTSM002347.9E-30222432IPR002913START domain
PfamPF018523.9E-32223432IPR002913START domain
SuperFamilySSF559614.95E-21453683No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008289Molecular Functionlipid binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 693 aa     Download sequence    Send to blast
MEFSGGGGGS SGGDDHDHPD SHRGKKRYHR HTAHQIQRLE SMFKECPHPD EKTRNQLSRE  60
LNLHPRQIKF WFQNRRTQMK AQHERADNSA LRAENDKIRC ENIAIREALK NVICPSCGSS  120
PASEDPYFDE QKLRIENAHL KEELDRVSSV AAKYIGRPIS QLPPVQPIHI SSLDLSMASF  180
GGHGNIAGPS LDLDLDLLRG SSSSLPFPQL TISDMDKSLM ADIAANAMDE LIRLLQSNEP  240
LWIKGGDGRE TLNLESYEKV FQSPYSHMKN PNIRIEASRD SGVVIMNSLA LVDMFMDAKK  300
WVELFPTIVS RAKTIEVISS GMLGSQSGTL QLAAVLAQIL SADEQGSWAV VDVSYDVPHQ  360
DGQFSSPCKA QRLPSGCLIQ EMPNGYSEVT WVEHWEVEEK APIHRLYRDL IHSGLAFGAE  420
RWLSTLQRAC ERFACLMVSG NSARDLGGVI PSPEGKRSMM KLAQRMVNNF CASINPANGQ  480
QWTTLSGLNE FEVRATLHKS SDPGQPSGVV LSAAATIWLP LPPTSVFNFF RDERTRPQWD  540
VLSNQNPVQE VAHIVNGSHP GNCISVLRAF NTSQNNMLIL QESCVDSSGS LVVYCPVDLP  600
AINMAMSGED PSYFPLLPSG FTISPDGRAQ DGGGGASTSI GGSSGSLITV VFQILVSNLP  660
SARLSPESVT TVNNLIGNTI HQIKAALNCS TTC
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011086973.10.0homeobox-leucine zipper protein HDG11
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A4D9AMS80.0A0A4D9AMS8_SALSN; Homeobox-leucine zipper protein
STRINGMigut.O00242.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA24902351
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]