PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID RrC6461_p2
Organism
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus
Family E2F/DP
Protein Properties Length: 352aa    MW: 39962.7 Da    PI: 9.1293
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
RrC6461_p2genomeMSUView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP70.61.9e-221176171
     E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                rkeksL++l ++fl+l+++ + + + l+++a +L    v  +rRRiYD++N+Le+++l++++ kn+++wkg
  RrC6461_p2 11 RKEKSLGVLVSNFLRLYNRDDVDLIGLDDAAGKL---GV--ERRRIYDVVNILESIGLVARRGKNQYSWKG 76
                79*****************999************...**..****************************98 PP

2E2F_TDP77.21.6e-24136216171
     E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                 +keksL++l+q+f+kl+ +s+++ +tl+ ++k+L++      ++++k+RR+YDi+NV++++nliek     ++k+++rw g
  RrC6461_p2 136 KKEKSLWVLAQNFVKLFLCSDDDLITLDGATKALLNVsqdpmNMRTKVRRLYDIANVFSSMNLIEKthipeTKKPAYRWLG 216
                 69********************************887999******************************99*******87 PP

Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-23777IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.45E-151074IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013725.9E-261176IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023191.6E-181276IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.1E-21134218IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013722.2E-28136216IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.8E-19137216IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467854.49E-12138217IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008284Biological Processpositive regulation of cell proliferation
GO:0009733Biological Processresponse to auxin
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 352 aa     Download sequence    Send to blast
MESLGRQSYS RKEKSLGVLV SNFLRLYNRD DVDLIGLDDA AGKLGVERRR IYDVVNILES  60
IGLVARRGKN QYSWKGFGQV PTVLSLLKEE GMREKFGIIP CVTNSEMVLY DQVREEPLKL  120
SPDDQENSPS PKLDCKKEKS LWVLAQNFVK LFLCSDDDLI TLDGATKALL NVSQDPMNMR  180
TKVRRLYDIA NVFSSMNLIE KTHIPETKKP AYRWLGPKAI SEARFLAAPL CDRIEPKKRV  240
FGTEITNFTT TKRAKTDCSK DQKQYESQNN TCSVIKQEQC DYKSAVKSLV GPLSPAGTSK  300
KTNPGKSNNQ SIDVLETLSS THKLQYCNHE LIGLLGHYTD TWRSWHEEFG RK
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A4e-32102083228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent regulation of gene expression. Binds specifically the E2 recognition site as a monomer without interacting with DP proteins. May be up-regulating E2FA and down-regulating repressors of cell cycle progression. Promotes cell proliferation and represses cell elongation. Regulated by proteolysis via a ubiquitin-proteasome pathway. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:19937368}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00511DAPTransfer from AT5G14960Download
Motif logo
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Down-regulated posttranscroptionally by auxin. {ECO:0000269|PubMed:19937368}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_018468078.10.0PREDICTED: E2F transcription factor-like E2FD
SwissprotQ9LFQ91e-162E2FD_ARATH; E2F transcription factor-like E2FD
TrEMBLA0A398A7J60.0A0A398A7J6_BRACM; Uncharacterized protein
STRINGBo2g012280.10.0(Brassica oleracea)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM60032547
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G14960.11e-164DP-E2F-like 2