PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus

Family

HD-ZIP

Protein Properties

Length: 306aa MW: 34691.1 Da PI: 4.3398

Description

HD-ZIP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
RrC5542_p2	genome	MSU	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	58.2	1.4e-18	62	115	3	56
--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS Homeobox 3 kRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56 k+++++ +q+++Le+ Fe ++++ e++ +LA++lgL+ rqV vWFqNrRa++k RrC5542_p2 62 KKRRLSVNQVKALEKNFELENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWK 115 566899***********************************************9 PP
2	HD-ZIP_I/II	129.5	1.4e-41	61	153	1	93
HD-ZIP_I/II 1 ekkrrlskeqvklLEesFeeeekLeperKvelareLglqprqvavWFqnrRARtktkqlEkdyeaLkraydalkeenerLekeveeLreelke 93 ekkrrls +qvk+LE++Fe e+kLeperKv+la+eLglqprqvavWFqnrRAR+ktkqlEkdy +Lk++yd+l+++ ++L++++e+L +e+++ RrC5542_p2 61 EKKRRLSVNQVKALEKNFELENKLEPERKVKLAQELGLQPRQVAVWFQNRRARWKTKQLEKDYGVLKTQYDSLRHNFDSLRRDNESLLQEISK 153 69*************************************************************************************999976 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS50071	17.07	57	117	IPR001356	Homeobox domain
SuperFamily	SSF46689	2.63E-18	60	119	IPR009057	Homeodomain-like
SMART	SM00389	2.6E-17	60	121	IPR001356	Homeobox domain
Pfam	PF00046	8.3E-16	62	115	IPR001356	Homeobox domain
CDD	cd00086	2.46E-15	62	118	No hit	No description
Gene3D	G3DSA:1.10.10.60	9.4E-20	64	124	IPR009057	Homeodomain-like
PRINTS	PR00031	8.4E-6	88	97	IPR000047	Helix-turn-helix motif
PROSITE pattern	PS00027	0	92	115	IPR017970	Homeobox, conserved site
PRINTS	PR00031	8.4E-6	97	113	IPR000047	Helix-turn-helix motif
Pfam	PF02183	4.0E-17	117	158	IPR003106	Leucine zipper, homeobox-associated

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0009414	Biological Process	response to water deprivation
GO:0009788	Biological Process	negative regulation of abscisic acid-activated signaling pathway
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 306 aa Download sequence Send to blast
MMKRLSSSDS VGGLISLCPT TSTDQQSPRR YGREFQSMLE GYEEEDEEAI IEERGQTGLA 60 EKKRRLSVNQ VKALEKNFEL ENKLEPERKV KLAQELGLQP RQVAVWFQNR RARWKTKQLE 120 KDYGVLKTQY DSLRHNFDSL RRDNESLLQE ISKLKSKLNG EEEEEEEENN AVTTESEFSV 180 KEEEVSLPEN ITEPPSSPPQ LLEHSDSFNY RSFTDLRDLL PLKASLAAAA AGSSDSSDSS 240 AVMNEESSSN VTVAPTTVPG GGFFQFVKTE QTEDHDDFLS GEEACGFFSD EQPPSLHWYS 300 TVDQWT

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	109	117	RRARWKTKQ

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that may act as growth regulators in response to water deficit. Interacts with the core sequence 5'-CAATTATTA-3' of promoters in response to ABA and in an ABI1-dependent manner. Involved in the negative regulation of the ABA signaling pathway. {ECO:0000269\|PubMed:10527431, ECO:0000269\|PubMed:12065416}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00271	DAP	Transfer from AT2G22430	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By water deficit, by abscisic acid (ABA) and by salt stress. Self expression regulation. {ECO:0000269\|PubMed:10527431, ECO:0000269\|PubMed:12065416, ECO:0000269\|PubMed:16055682}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AY336103	0.0	AY336103.1 Brassica napus homeodomain-leucine zipper protein mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	NP_001302743.1	1e-175	homeobox-leucine zipper protein ATHB-6-like
Refseq	XP_006404700.1	1e-175	homeobox-leucine zipper protein ATHB-6
Refseq	XP_009112528.1	1e-175	PREDICTED: homeobox-leucine zipper protein ATHB-6
Refseq	XP_013605522.1	1e-175	PREDICTED: homeobox-leucine zipper protein ATHB-6-like
Swissprot	P46668	1e-169	ATHB6_ARATH; Homeobox-leucine zipper protein ATHB-6
TrEMBL	A0A397YAL8	1e-175	A0A397YAL8_BRACM; Uncharacterized protein
STRING	Bra038523.1-P	1e-175	(Brassica rapa)
STRING	Bo8g101130.1	1e-175	(Brassica oleracea)
STRING	XP_006404700.1	1e-175	(Eutrema salsugineum)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM545	28	143

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G22430.1	1e-139	homeobox protein 6

Publications ? help Back to Top
Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Song L, et al. A transcription factor hierarchy defines an environmental stress response network. Science, 2017. [PMID:27811239]