PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus

Family

MYB

Protein Properties

Length: 273aa MW: 30979.2 Da PI: 9.6289

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
RrC4410_p1	genome	MSU	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	50.2	6e-16	83	128	1	47
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqky 47 rg W + Ed +l+++v+q+G+ +W+ I++++ gR++k+c++rw++ RrC4410_p1 83 RGHWRPTEDAKLKELVAQFGPQNWNVISNHLL-GRSGKSCRLRWFNQ 128 899**************************9.*********996 PP
2	Myb_DNA-binding	52.6	1e-16	135	178	1	46
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46 + ++T+eE+++l+ +++ +G++ W++I+r ++ gRt++ +k++w+ RrC4410_p1 135 KSAFTEEEELRLLAVHRAYGNK-WALISRLFP-GRTDNAVKNHWHV 178 578*****************.*****.*********96 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	15.206	78	129	IPR017930	Myb domain
SMART	SM00717	2.5E-13	82	131	IPR001005	SANT/Myb domain
SuperFamily	SSF46689	6.36E-28	83	176	IPR009057	Homeodomain-like
Pfam	PF00249	2.2E-15	83	128	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	1.2E-24	84	136	IPR009057	Homeodomain-like
CDD	cd00167	2.91E-12	86	127	No hit	No description
PROSITE profile	PS51294	24.747	130	184	IPR017930	Myb domain
SMART	SM00717	4.6E-14	134	182	IPR001005	SANT/Myb domain
Pfam	PF00249	3.0E-14	135	177	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	8.7E-20	137	183	IPR009057	Homeodomain-like
CDD	cd00167	1.01E-10	137	177	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 273 aa Download sequence Send to blast
MNQNLLKKNL TGNYTINDSR RFQERNNFRS LPNSDTNFSL ARNYPHNKSV SGLESGDEHG 60 KERGGNGLKR RGKNGINSKL CSRGHWRPTE DAKLKELVAQ FGPQNWNVIS NHLLGRSGKS 120 CRLRWFNQLD PRINKSAFTE EEELRLLAVH RAYGNKWALI SRLFPGRTDN AVKNHWHVIM 180 ARRTRESQRQ RHQPPEAPSG NTEMAVSSSY NHGDEFFGTV ANGTFVNEED DDDDGSAVST 240 CTTELSLTPP SSTHQPRFFN YDYTLASGNN LCI

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1a5j_A	5e-32	83	184	7	108	B-MYB
1mse_C	4e-32	80	184	1	105	C-Myb DNA-Binding Domain
1msf_C	4e-32	80	184	1	105	C-Myb DNA-Binding Domain
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Acts as a cell-specific local repressor of quiescent center (QC) self-renewal by cell divisions in the primary root. Counteracts brassinosteroid (BR)-mediated cell division in the QC cells (PubMed:24981610). Regulates maternally seed size, especially before the heart stage, promoting both endothelial cells expansion and cell number in the outer integument layer of the seed coat (PubMed:23911125). Modulates the expression of genes involved in cell wall metabolism such as cell division and expansion (PubMed:23911125, PubMed:24981610). Negative regulator of flowering via the repression of FT transcription (PubMed:25343985). {ECO:0000269\|PubMed:23911125, ECO:0000269\|PubMed:24981610, ECO:0000269\|PubMed:25343985}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Levels follow a circadian cycle with a progressive decrease during the day time (at protein level) (PubMed:25343985). Down-regulated by brassinosteroids (BRs) in a dose- and time-dependent manner. Repressed by BES1. Auto-activation of expression (PubMed:24981610). Targeted to 26S proteasomal degradation by the CULLIN3 (CUL3)-based E3 ligases CRL3(BPMs) (PubMed:25343985). {ECO:0000269\|PubMed:24981610, ECO:0000269\|PubMed:25343985}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	KC966739	0.0	KC966739.1 Brassica napus MYB transcription factor 56 (MYB56.1) mRNA, complete cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_018443078.1	1e-162	PREDICTED: transcription factor MYB21
Swissprot	Q6R053	1e-138	MYB56_ARATH; Transcription factor MYB56
TrEMBL	A0A3P6DBA8	1e-156	A0A3P6DBA8_BRAOL; Uncharacterized protein
STRING	Bo2g013970.1	1e-155	(Brassica oleracea)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM9977	18	36

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G17800.1	1e-116	myb domain protein 56

Publications ? help Back to Top
Chen L,Bernhardt A,Lee J,Hellmann H Identification of Arabidopsis MYB56 as a novel substrate for CRL3BPM E3 ligases. Mol Plant, 2015. [PMID:25343985] Frigola D,Caño-Delgado AI,Ibañes M Methods for Modeling Brassinosteroid-Mediated Signaling in Plant Development. Methods Mol. Biol., 2017. 1564: p. 103-120 [PMID:28124249] Espinosa-Ruiz A, et al. TOPLESS mediates brassinosteroid control of shoot boundaries and root meristem development in Arabidopsis thaliana. Development, 2017. 144(9): p. 1619-1628 [PMID:28320734] Jeong CY, et al. AtMyb56 Regulates Anthocyanin Levels via the Modulation of AtGPT2 Expression in Response to Sucrose in Arabidopsis. Mol. Cells, 2018. 41(4): p. 351-361 [PMID:29487277]