PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Brassiceae; Raphanus

Family

NAC

Protein Properties

Length: 325aa MW: 36500.9 Da PI: 5.7917

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
RrC16390_p1	genome	MSU	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	175	2.2e-54	20	146	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlskkge 98 lppGfrFhPtdee++++yLk+kv + ++++ +i +vd++k ePwdLpk +k +eke yfF++rd+ky+tg r+nrat sgyWkatgkdke+++ k+ RrC16390_p1 20 LPPGFRFHPTDEEIITHYLKEKVFNVQFTA-AAIGQVDLNKNEPWDLPKIAKMGEKEFYFFCQRDRKYPTGMRTNRATLSGYWKATGKDKEIFRGKDC 116 79***********************999.78***********8888899***********************************9999 PP NAM 99 lvglkktLvfykgrapkgektdWvmheyrl 128 vg+kktLvfy+grapkgektdWvmheyrl RrC16390_p1 117 IVGMKKTLVFYRGRAPKGEKTDWVMHEYRL 146 9*************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	1.31E-61	17	172	IPR003441	NAC domain
PROSITE profile	PS51005	57.982	20	171	IPR003441	NAC domain
Pfam	PF02365	2.1E-28	21	146	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 325 aa Download sequence Send to blast
MVEEVGVVVN QGGDHEAVDL PPGFRFHPTD EEIITHYLKE KVFNVQFTAA AIGQVDLNKN 60 EPWDLPKIAK MGEKEFYFFC QRDRKYPTGM RTNRATLSGY WKATGKDKEI FRGKDCIVGM 120 KKTLVFYRGR APKGEKTDWV MHEYRLDGKY SYQNLPRSAR DEWVVCRVFH KNAPPINTTT 180 TTSNQLIGSE SLDNIDHLLD FSALPPLIDP GFLVQPGPSF SVAGQQNNLN PILHHSTTVA 240 INSTYFPAKT VYTYHSDPNC GSGFGYGTGS GNNNNGIKFE HSLMSVSQET GLSSDMNTTT 300 SPEICNDMSN DDDDLGIFWD DYKLI

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
3ulx_A	2e-49	14	172	8	169	Stress-induced transcription factor NAC1
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcriptional activator that acts as positive regulator of leaf senescence. Activates NYC1, SGR1, SGR2 and PAO, which are genes involved in chlorophyll catabolic processes. Activates senescence-associated genes, such as RNS1, SAG12 and SAG13. {ECO:0000269\|PubMed:27021284}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_018489808.1	0.0	PREDICTED: NAC domain-containing protein 92
Swissprot	Q9SQQ6	0.0	NAC46_ARATH; NAC domain-containing protein 46
TrEMBL	M4ET20	0.0	M4ET20_BRARP; Uncharacterized protein
STRING	Bra031950.1-P	0.0	(Brassica rapa)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM2269	27	75

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G04060.1	1e-168	NAC domain containing protein 46

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Oda-Yamamizo C, et al. Corrigendum: The NAC transcription factor ANAC046 is a positive regulator of chlorophyll degradation and senescence in Arabidopsis leaves. Sci Rep, 2016. 6: p. 35125 [PMID:27759025] O'Shea C, et al. Structures and Short Linear Motif of Disordered Transcription Factor Regions Provide Clues to the Interactome of the Cellular Hub Protein Radical-induced Cell Death1. J. Biol. Chem., 2017. 292(2): p. 512-527 [PMID:27881680]