PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Amygdaleae; Prunus

Family

C2H2

Protein Properties

Length: 525aa MW: 57512.7 Da PI: 9.0052

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Prupe.6G323100.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	16.3	2.9e-05	93	115	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++C++C+k F r nL+ H r H Prupe.6G323100.1.p 93 FVCEICKKGFQRDQNLQLHRRGH 115 89*******************88 PP
2	zf-C2H2	12	0.00062	169	191	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k + +s+ k H +t+ Prupe.6G323100.1.p 169 WKCDKCSKKYAVQSDWKAHSKTC 191 58*****************9998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.30.160.60	1.1E-4	92	115	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.87E-6	92	115	No hit	No description
SMART	SM00355	0.039	93	115	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.637	93	115	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	95	115	IPR007087	Zinc finger, C2H2
SMART	SM00355	210	134	164	IPR015880	Zinc finger, C2H2-like
Gene3D	G3DSA:3.30.160.60	5.4E-4	157	190	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.87E-6	164	189	No hit	No description
SMART	SM00355	150	169	189	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 525 aa Download sequence Send to blast
MSIITGSAAG SFSSGNTGGE EVQQQQQQEL LNHANFHGSN SFLSTTPPNI NSNGTQPKQP 60 PQVKRKRNLP GTPDPSAEVV ALSPKTLMAT NRFVCEICKK GFQRDQNLQL HRRGHNLPWK 120 LKQRTSTEII KRVYVCPEPS CVHHDPSRAL GDLTGIKKHF CRKHGEKKWK CDKCSKKYAV 180 QSDWKAHSKT CGTREYKCDC GTIFSRRDSF ITHRAFCDAI AEENNTANQG VLMSNNINNG 240 APILQGQVSN SDLISPSSIN NSNKTTNNPS TRSSTTSDQF NHNFDTKIPL SLVPQQPLPM 300 SSKPLNMLPR SLNNNNNNNT SSSSPSPLLF ELSHGHGLIP SSSGHLSATE LLQKAAQMGA 360 TMSSTSPSPS GTTITSMAPS TYGTTTTGGY NVNPFMQHRD HHNVNVSPQL ENSFFGANNY 420 AQMGMYGGLL FDPHQNNGLL KNMEQDNNGN SSKFGLRGTN VSGGDTLTVD FLGIGGSANV 480 NRPEDFHGQQ KQQHDQHQQQ QQQQQDQLGF GGIDDDHLRM QRFN*

Sequence ? help Back to Top

Protein Sequence Length: 525 aa Download sequence Send to blast

MSIITGSAAG SFSSGNTGGE EVQQQQQQEL LNHANFHGSN SFLSTTPPNI NSNGTQPKQP  60
PQVKRKRNLP GTPDPSAEVV ALSPKTLMAT NRFVCEICKK GFQRDQNLQL HRRGHNLPWK  120
LKQRTSTEII KRVYVCPEPS CVHHDPSRAL GDLTGIKKHF CRKHGEKKWK CDKCSKKYAV  180
QSDWKAHSKT CGTREYKCDC GTIFSRRDSF ITHRAFCDAI AEENNTANQG VLMSNNINNG  240
APILQGQVSN SDLISPSSIN NSNKTTNNPS TRSSTTSDQF NHNFDTKIPL SLVPQQPLPM  300
SSKPLNMLPR SLNNNNNNNT SSSSPSPLLF ELSHGHGLIP SSSGHLSATE LLQKAAQMGA  360
TMSSTSPSPS GTTITSMAPS TYGTTTTGGY NVNPFMQHRD HHNVNVSPQL ENSFFGANNY  420
AQMGMYGGLL FDPHQNNGLL KNMEQDNNGN SSKFGLRGTN VSGGDTLTVD FLGIGGSANV  480
NRPEDFHGQQ KQQHDQHQQQ QQQQQDQLGF GGIDDDHLRM QRFN*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	4e-34	165	236	3	72	Zinc finger protein JACKDAW
5b3h_F	4e-34	165	236	3	72	Zinc finger protein JACKDAW
Search in ModeBase

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Observed in vegetative tissues. Mainly expressed in hypocotyls, petioles, shoot apices, root tips, and trichomes, and, at low levels, in leaves, stems and flowers. {ECO:0000269\|PubMed:25035403}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269\|PubMed:25035403}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Prupe.6G323100.1.p

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_007207116.1	0.0	protein indeterminate-domain 2
Swissprot	Q9SCQ6	1e-112	IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBL	M5WNC7	0.0	M5WNC7_PRUPE; Uncharacterized protein
STRING	EMJ08315	0.0	(Prunus persica)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF2192	30	85

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G03840.1	1e-101	C2H2 family protein

Link Out ? help Back to Top
Phytozome	Prupe.6G323100.1.p
Entrez Gene	18775531

Publications ? help Back to Top
Fukazawa J, et al. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Plant Cell, 2014. 26(7): p. 2920-38 [PMID:25035403] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Khare D, et al. Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana. New Phytol., 2017. 213(3): p. 1257-1273 [PMID:27768815]