PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Amygdaleae; Prunus

Family

MYB

Protein Properties

Length: 566aa MW: 62053.3 Da PI: 7.0578

Description

MYB family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Prupe.6G255400.2.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Myb_DNA-binding	51	3.3e-16	75	121	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 +g WT++Ede l +av+ + g++Wk+Ia+ ++ R++ qc +rwqk+l Prupe.6G255400.2.p 75 KGGWTPQEDETLRNAVAAFKGKSWKKIAEFFP-DRSEVQCLHRWQKVL 121 688***************************.**********986 PP
2	Myb_DNA-binding	62.7	7.1e-20	127	173	1	48
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHHHT CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqkyl 48 +g+WT+eEd++++++v+++G+ W++Ia+ ++ gR +kqc++rw+++l Prupe.6G255400.2.p 127 KGPWTQEEDDKIIELVAKYGPTKWSLIAKSLP-GRIGKQCRERWHNHL 173 79****************************.***********97 PP
3	Myb_DNA-binding	54.6	2.4e-17	179	222	1	46
TSSS-HHHHHHHHHHHHHTTTT-HHHHHHHHTTTS-HHHHHHHHHH CS Myb_DNA-binding 1 rgrWTteEdellvdavkqlGggtWktIartmgkgRtlkqcksrwqk 46 +++WT eE++ l +a++ +G++ W+ Ia+ ++ gRt++ +k++w++ Prupe.6G255400.2.p 179 KDAWTLEEELALMNAHRIHGNK-WAEIAKVLP-GRTDNAIKNHWNS 222 679*****************.*****.*********96 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
PROSITE profile	PS51294	14.982	70	121	IPR017930	Myb domain
SuperFamily	SSF46689	9.33E-15	72	128	IPR009057	Homeodomain-like
SMART	SM00717	5.3E-14	74	123	IPR001005	SANT/Myb domain
Pfam	PF00249	5.9E-15	75	121	IPR001005	SANT/Myb domain
Gene3D	G3DSA:1.10.10.60	3.8E-22	77	129	IPR009057	Homeodomain-like
CDD	cd00167	3.55E-12	78	121	No hit	No description
PROSITE profile	PS51294	33.805	122	177	IPR017930	Myb domain
SuperFamily	SSF46689	5.14E-32	124	220	IPR009057	Homeodomain-like
SMART	SM00717	6.7E-19	126	175	IPR001005	SANT/Myb domain
Pfam	PF00249	2.7E-19	127	173	IPR001005	SANT/Myb domain
CDD	cd00167	1.07E-16	129	173	No hit	No description
Gene3D	G3DSA:1.10.10.60	3.6E-28	130	176	IPR009057	Homeodomain-like
Gene3D	G3DSA:1.10.10.60	2.6E-23	177	228	IPR009057	Homeodomain-like
SMART	SM00717	2.6E-16	178	226	IPR001005	SANT/Myb domain
PROSITE profile	PS51294	22.62	178	228	IPR017930	Myb domain
Pfam	PF00249	1.9E-15	179	222	IPR001005	SANT/Myb domain
CDD	cd00167	1.66E-12	181	224	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 566 aa Download sequence Send to blast
MSSNSIPATS SQAWEEMEEV KLEECCLENK QSTAASSSSV SEGSGSAILK SPGVCSPAST 60 SPTHRRTSGP IRRAKGGWTP QEDETLRNAV AAFKGKSWKK IAEFFPDRSE VQCLHRWQKV 120 LNPDLVKGPW TQEEDDKIIE LVAKYGPTKW SLIAKSLPGR IGKQCRERWH NHLNPDIKKD 180 AWTLEEELAL MNAHRIHGNK WAEIAKVLPG RTDNAIKNHW NSSLKKKLDF YLATGKLPPA 240 AKNGSQNGAK ETNVCKLDED GKDQFESSAP HQDLGASSSV LPNEPADSEG VECQLRSSFR 300 DLSCCNSESG SKFENFAVNS KPQIESIINS QAESENCGFN NLVDEDRVKR TPVPVETPGY 360 GSLYYEPPLE SCGPFDSGFS SMRCFQHDYA SSPNVSPISF YTPPCVKGSG LCNRSPESIL 420 KMAAKTFPNT PSILRKRKNT SQGHLPPNKI GLVDCESVRE VLNVSDEQER HKNSAEMSGS 480 QEESLCESPT SQGISTIGPN GKAFNASPPY RLRARRTAVF KSVEKQLEFT CDKEYDGNSK 540 SVELSANGGS GVIKDCSHAT KMEVT*

Sequence ? help Back to Top

Protein Sequence Length: 566 aa Download sequence Send to blast

MSSNSIPATS SQAWEEMEEV KLEECCLENK QSTAASSSSV SEGSGSAILK SPGVCSPAST  60
SPTHRRTSGP IRRAKGGWTP QEDETLRNAV AAFKGKSWKK IAEFFPDRSE VQCLHRWQKV  120
LNPDLVKGPW TQEEDDKIIE LVAKYGPTKW SLIAKSLPGR IGKQCRERWH NHLNPDIKKD  180
AWTLEEELAL MNAHRIHGNK WAEIAKVLPG RTDNAIKNHW NSSLKKKLDF YLATGKLPPA  240
AKNGSQNGAK ETNVCKLDED GKDQFESSAP HQDLGASSSV LPNEPADSEG VECQLRSSFR  300
DLSCCNSESG SKFENFAVNS KPQIESIINS QAESENCGFN NLVDEDRVKR TPVPVETPGY  360
GSLYYEPPLE SCGPFDSGFS SMRCFQHDYA SSPNVSPISF YTPPCVKGSG LCNRSPESIL  420
KMAAKTFPNT PSILRKRKNT SQGHLPPNKI GLVDCESVRE VLNVSDEQER HKNSAEMSGS  480
QEESLCESPT SQGISTIGPN GKAFNASPPY RLRARRTAVF KSVEKQLEFT CDKEYDGNSK  540
SVELSANGGS GVIKDCSHAT KMEVT*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1h88_C	2e-68	74	228	5	159	MYB PROTO-ONCOGENE PROTEIN
1h89_C	2e-68	74	228	5	159	MYB PROTO-ONCOGENE PROTEIN
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Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed both in proliferating and maturing stages of leaves. {ECO:0000269\|PubMed:26069325}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that binds 5'-AACGG-3' motifs in gene promoters (By similarity). Transcription repressor that regulates organ growth. Binds to the promoters of G2/M-specific genes and to E2F target genes to prevent their expression in post-mitotic cells and to restrict the time window of their expression in proliferating cells (PubMed:26069325). {ECO:0000250\|UniProtKB:Q94FL9, ECO:0000269\|PubMed:26069325}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00482	DAP	Transfer from AT5G02320	Download

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Prupe.6G255400.2.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Slightly induced by ethylene and salicylic acid (SA). {ECO:0000269\|PubMed:16463103}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	Retrieve

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_020423086.1	0.0	transcription factor MYB3R-3
Swissprot	Q6R032	1e-167	MB3R5_ARATH; Transcription factor MYB3R-5
TrEMBL	A0A251NXB0	0.0	A0A251NXB0_PRUPE; Uncharacterized protein
STRING	EMJ09642	0.0	(Prunus persica)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G02320.2	1e-154	myb domain protein 3r-5

Link Out ? help Back to Top
Phytozome	Prupe.6G255400.2.p
Entrez Gene	18774406

Publications ? help Back to Top
Ding Y, et al. Four distinct types of dehydration stress memory genes in Arabidopsis thaliana. BMC Plant Biol., 2013. 13: p. 229 [PMID:24377444] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325] Chen P, et al. Arabidopsis R1R2R3-Myb proteins are essential for inhibiting cell division in response to DNA damage. Nat Commun, 2017. 8(1): p. 635 [PMID:28935922]