PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Rosaceae; Maloideae; Amygdaleae; Prunus

Family

E2F/DP

Protein Properties

Length: 463aa MW: 51115.1 Da PI: 4.5702

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Prupe.6G139900.2.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	85.9	3.1e-27	142	207	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r ++sL+llt+kf++l++++e+gi++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Prupe.6G139900.2.p 142 RFDSSLGLLTKKFINLIKHAEDGILDLNNAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 207 6789****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	1.2E-28	140	209	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.7E-34	142	207	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	5.71E-17	142	205	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.6E-24	144	207	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	1.15E-33	219	324	No hit	No description
CDD	cd14660	3.07E-48	222	324	No hit	No description
Pfam	PF16421	2.9E-33	223	322	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 463 aa Download sequence Send to blast
MSGSRAHDPP AQPPQPIMQQ ALKRQLAFSS MKPPFSATAD YHGFVPDPRQ LTDSEAYGIY 60 VKPSQKRKSD AADYEAESSD RTAAPGYTEV VTSPLQTPVS SKVGKANKTS RLTKCSRSGP 120 QTPASNVGSP SGANLTPAGP CRFDSSLGLL TKKFINLIKH AEDGILDLNN AADTLEVQKR 180 RIYDITNVLE GIGLIEKKLK NRIQWKGLDV SRTGDVDENY PSLQAQVENL SDEERRLDQQ 240 IREMQERLRD LSEDESNKKW LFVTEEDIKG LPCLQNETLI AIKAPHGTTL EVPDPDEAVD 300 YPQRRYRMVL RSTMGPIDVY LVSQFEEKFE EINGVEVPTD IPSSSGVNEN PATTMVTENR 360 GKDVEIQGPD DHRMCADPTA SQDIMSGMMK IVPSDVDSDA DYWLLSDADI SITDMWRTEP 420 GVVWNELGAI DEDYMVNVST PRPQTPPSSS TQVPATANRT KT*

Sequence ? help Back to Top

Protein Sequence Length: 463 aa Download sequence Send to blast

MSGSRAHDPP AQPPQPIMQQ ALKRQLAFSS MKPPFSATAD YHGFVPDPRQ LTDSEAYGIY  60
VKPSQKRKSD AADYEAESSD RTAAPGYTEV VTSPLQTPVS SKVGKANKTS RLTKCSRSGP  120
QTPASNVGSP SGANLTPAGP CRFDSSLGLL TKKFINLIKH AEDGILDLNN AADTLEVQKR  180
RIYDITNVLE GIGLIEKKLK NRIQWKGLDV SRTGDVDENY PSLQAQVENL SDEERRLDQQ  240
IREMQERLRD LSEDESNKKW LFVTEEDIKG LPCLQNETLI AIKAPHGTTL EVPDPDEAVD  300
YPQRRYRMVL RSTMGPIDVY LVSQFEEKFE EINGVEVPTD IPSSSGVNEN PATTMVTENR  360
GKDVEIQGPD DHRMCADPTA SQDIMSGMMK IVPSDVDSDA DYWLLSDADI SITDMWRTEP  420
GVVWNELGAI DEDYMVNVST PRPQTPPSSS TQVPATANRT KT*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	1e-26	137	208	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Expression -- Description ? help Back to Top
Source	Description
Uniprot	DEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Most abundant at the G1/S transition. Lower but constant level in the following phases. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:16514015}.
Uniprot	TISSUE SPECIFICITY: Expressed in proliferating cells and several differentiated tissues. Detected in inflorescence and shoot apical meristems, cotyledonary vascular tissues, leaf primordia, young leaves, base of trichomes, central cylinder and elongation zone of roots, lateral root primordia, flowers, pistils of immature flowers and pollen grains. {ECO:0000269\|PubMed:16514015}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Prupe.6G139900.2.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_007208279.2	0.0	transcription factor E2FB isoform X2
Swissprot	Q9FV71	1e-153	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A251NQ53	0.0	A0A251NQ53_PRUPE; Uncharacterized protein
STRING	EMJ09478	0.0	(Prunus persica)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G22220.2	1e-152	E2F transcription factor 1

Link Out ? help Back to Top
Phytozome	Prupe.6G139900.2.p

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]