PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Pp3c4_18030V3.1.p
Organism
Physcomitrella patens
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Bryophyta; Bryophytina; Bryopsida; Funariidae; Funariales; Funariaceae; Physcomitrella
Family C2H2
Protein Properties Length: 463aa    MW: 52933.5 Da    PI: 7.2405
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Pp3c4_18030V3.1.pgenomeCOSMOSSView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H211.10.0012219241123
                        EEETTTTEEESSHHHHHHHHHHT CS
            zf-C2H2   1 ykCpdCgksFsrksnLkrHirtH 23 
                        + C+ C    +rk++L rH+r++
  Pp3c4_18030V3.1.p 219 FFCEFCLSFVKRKEQLARHMRKC 241
                        67*******************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF541602.38E-2271150IPR016197Chromo domain-like
Gene3DG3DSA:2.30.30.2703.6E-3775145No hitNo description
PfamPF117173.7E-2076132IPR025995RNA binding activity-knot of a chromodomain
SMARTSM002980.001590148IPR000953Chromo/chromo shadow domain
CDDcd000243.78E-595140No hitNo description
Gene3DG3DSA:2.30.30.2703.6E-37180230No hitNo description
PROSITE profilePS5172675.835185456IPR002717Histone acetyltransferase domain, MYST-type
SuperFamilySSF557292.61E-111186457IPR016181Acyl-CoA N-acyltransferase
Gene3DG3DSA:3.40.630.301.4E-72244386IPR016181Acyl-CoA N-acyltransferase
PfamPF018537.0E-84246423IPR002717Histone acetyltransferase domain, MYST-type
CDDcd043010.00458297355No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006281Biological ProcessDNA repair
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0010224Biological Processresponse to UV-B
GO:0016573Biological Processhistone acetylation
GO:2000028Biological Processregulation of photoperiodism, flowering
GO:0005634Cellular Componentnucleus
GO:0043995Molecular Functionhistone acetyltransferase activity (H4-K5 specific)
Sequence ? help Back to Top
Protein Sequence    Length: 463 aa     Download sequence    Send to blast
MGSLEQNAPA GRGMGVETVA GILREEIPIA NNLTPGAAVM DGSQQQNSGV NHHHEVSVMA  60
AAGNGLKKRV TIPLPLEVGT RVLCRWRDGK LHPVKVIERR KLNSGPDDYQ YYVHYNEFNR  120
RLDEWVKLDQ LELESVEADA DEKVEDKAGG LKMTRHQKRK IEETHAEEGH EDFDAASLRE  180
HEEFTKVKNI SKIELGRYEI DTWYFSPFPP EYSDCSKLFF CEFCLSFVKR KEQLARHMRK  240
CDLKHPPGDE IYRQGSLSMF EVDGKKNKIY GQNLCYLAKL FLDHKTLYYD VDLFLFYILC  300
ECDDRGCHMV GYFSKEKHSE EGYNLACILT LPPYQRKGYG KFLIAFSYEL SKKEGKVGTP  360
ERPLSDLGLL SYRGYWTRIL LDILKKHRGN VSIKELSDMT AIKTEDVITT LQTLELIQYR  420
KGQHVICADP KLLERHLKAA GRGGLDVDAS KLIWTPYKEQ GG*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4dnc_A1e-1221814601282Histone acetyltransferase KAT8
4dnc_B1e-1221814601282Histone acetyltransferase KAT8
Search in ModeBase
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Ppa.154070.0gametophore| protonema
Expression -- Description ? help Back to Top
Source Description
UniprotTISSUE SPECIFICITY: Expressed in cotyledons, leaves, stems, roots and, at higher levels in developing flowers, particularly in the anthers and gynoecia (PubMed:19040736). Constitutively expressed in all tissues, predominantly in shoot apical meristem (PubMed:23273925). {ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:23273925}.
Functional Description ? help Back to Top
Source Description
UniProtHistone acetyltransferase which may be involved in transcriptional activation. Acetylates 'Lys-5' of histone H4 (H4K5ac) (PubMed:17877703, PubMed:19040736, PubMed:22170978, PubMed:23273925). Essential for gametophyte development (PubMed:19040736). Involved in DNA repair after UV-B exposure (PubMed:22170978). Negative regulator of flowering controlling the H4K5ac levels in the FLC chromatin (PubMed:23273925). {ECO:0000269|PubMed:17877703, ECO:0000269|PubMed:19040736, ECO:0000269|PubMed:22170978, ECO:0000269|PubMed:23273925}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Up-regulated upon UV-B exposure. {ECO:0000269|PubMed:22170978}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024374032.10.0putative MYST-like histone acetyltransferase 1
SwissprotQ9FLF70.0MYST1_ARATH; Histone acetyltransferase of the MYST family 1
TrEMBLA0A2K1KNZ90.0A0A2K1KNZ9_PHYPA; Histone acetyltransferase
STRINGPP1S13_111V6.10.0(Physcomitrella patens)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
Representative plantOGRP389045
Publications ? help Back to Top
  1. Latrasse D, et al.
    The MYST histone acetyltransferases are essential for gametophyte development in Arabidopsis.
    BMC Plant Biol., 2008. 8: p. 121
    [PMID:19040736]
  2. Campi M,D'Andrea L,Emiliani J,Casati P
    Participation of chromatin-remodeling proteins in the repair of ultraviolet-B-damaged DNA.
    Plant Physiol., 2012. 158(2): p. 981-95
    [PMID:22170978]
  3. Bari A,Orazova S,Ivashchenko A
    miR156- and miR171-binding sites in the protein-coding sequences of several plant genes.
    Biomed Res Int, 2013. 2013: p. 307145
    [PMID:23936788]
  4. Xu Y, et al.
    Arabidopsis MRG domain proteins bridge two histone modifications to elevate expression of flowering genes.
    Nucleic Acids Res., 2014. 42(17): p. 10960-74
    [PMID:25183522]
  5. Raevsky AV,Sharifi M,Samofalova DA,Karpov PA,Blume YB
    3D structure prediction of histone acetyltransferase proteins of the MYST family and their interactome in Arabidopsis thaliana.
    J Mol Model, 2016. 22(11): p. 256
    [PMID:27709438]
  6. Fina JP,Masotti F,Rius SP,Crevacuore F,Casati P
    HAC1 and HAF1 Histone Acetyltransferases Have Different Roles in UV-B Responses in Arabidopsis.
    Front Plant Sci, 2017. 8: p. 1179
    [PMID:28740501]