PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Potri.015G070300.1
Organism
Populus trichocarpa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus
Family E2F/DP
Protein Properties Length: 387aa    MW: 43491 Da    PI: 9.0408
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Potri.015G070300.1genomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP57.62e-1833871271
             E2F_TDP 12 kflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                        +fl+l+++ + +++ l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Potri.015G070300.1 33 SFLTLYNRDDIDVIGLDDAASKL---GV--ERRRIYDIVNVLESVGVLARKAKNKYSWKG 87
                        689****9988************...**..****************************98 PP
2E2F_TDP741.6e-23158238171
             E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                         r+eksL+lltq+f+kl+ +s+++ ++l+e ak L+ +      +++k+RR+YDi+NVL++l+liek     ++k+++rw g
  Potri.015G070300.1 158 RREKSLGLLTQNFVKLFVCSNANLISLDESAKLLLGDghnlsIMRTKVRRLYDIANVLSSLKLIEKthtadTRKPAFRWLG 238
                         689***************************************9***************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SMARTSM013728.0E-182387IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.3E-122985IPR011991Winged helix-turn-helix DNA-binding domain
Gene3DG3DSA:1.10.10.101.3E-183188IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023193.0E-153387IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.0E-22154239IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.0E-28158238IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.8E-18160238IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467856.39E-12160239IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 387 aa     Download sequence    Send to blast
MHQVNKPIFP FSFLSKAQNF PGIKLIFICL FCSFLTLYNR DDIDVIGLDD AASKLGVERR  60
RIYDIVNVLE SVGVLARKAK NKYSWKGFAS VPKALQDLKE EGLRDNVNTI DRQSNNSAKV  120
ANDDEDEDDD SDSNPNTGSQ NENSSIIKSM AVSRSDHRRE KSLGLLTQNF VKLFVCSNAN  180
LISLDESAKL LLGDGHNLSI MRTKVRRLYD IANVLSSLKL IEKTHTADTR KPAFRWLGFR  240
GKSENGSGDP LAPFESRKRT FGADITNTCF KRNKMDSSVD GDKSQNLKMQ QIKDENMVTV  300
AERGNFGQDL QQKSGSFQFG PFAPVSVAKA GNPEDNVTRI YDWEGLSSTF RPQYHNQALR  360
DLFSHYTEAW KLWYTEVAGK KPLHIS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-314623032228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapPotri.015G070300.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_002321561.30.0E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-117E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A2K1XJ940.0A0A2K1XJ94_POPTR; Uncharacterized protein
STRINGPOPTR_0015s08160.10.0(Populus trichocarpa)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Representative plantOGRP24741634
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-120DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]