PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Salicaceae; Saliceae; Populus

Family

C2H2

Protein Properties

Length: 472aa MW: 52308.7 Da PI: 9.2623

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Potri.014G132700.1	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	17.6	1.1e-05	6	28	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 ++C++C+k F r nL+ H r H Potri.014G132700.1 6 FVCEICNKGFQRDQNLQFHRRGH 28 89*******************88 PP
2	zf-C2H2	16.6	2.3e-05	64	86	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k + +s+ k H+rt+ Potri.014G132700.1 64 WKCDKCSKKYAVQSDWKAHQRTC 86 58*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	3.93E-9	5	28	No hit	No description
Gene3D	G3DSA:3.30.160.60	4.1E-5	5	28	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SMART	SM00355	0.069	6	28	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	10.824	6	28	IPR007087	Zinc finger, C2H2
PROSITE pattern	PS00028	0	8	28	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	3.1E-6	52	85	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	3.93E-9	59	85	No hit	No description
SMART	SM00355	85	64	84	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 472 aa Download sequence Send to blast
METNRFVCEI CNKGFQRDQN LQFHRRGHNP PWKLWQRTAT EVRKRVYLTG IKKHFSRNNG 60 EKKWKCDKCS KKYAVQSDWK AHQRTCGTRE YKCDCGTIFS RRDCFITHRA FCDALAEENS 120 KVNQGVMANM GSNLQNQMSE PMSSHSMPLS TDTSTSIGMP YFNSFDPKNS LKYLPQELVP 180 IPSKSMNMAG GMFSSSSGTL FGSPRSISST SSLQLSSKGS SGLHYLQDNK NGCQISASAH 240 MSATAMLKEA AQMGATASNS INSPVMQKSF ASSMAGPHDQ LSSIKPPTYG RIQQHNTSYD 300 HLPLHASGQT SMAGINGVGG FSNQPLQRGP QETSQILDTS GTVNSAMNDM EMFTGVFMSN 360 DQNPGFIRNM EQEDSGGSSL IHGRNPLMER NPTGPSRFAG TSIEGGDMMT RDFRGVGGAR 420 PTNLHDQRQQ HQQRLEMEGM SQQQRMPMMN PFQQQPSLRE SAMEKPSIWD V*

Sequence ? help Back to Top

Protein Sequence Length: 472 aa Download sequence Send to blast

METNRFVCEI CNKGFQRDQN LQFHRRGHNP PWKLWQRTAT EVRKRVYLTG IKKHFSRNNG  60
EKKWKCDKCS KKYAVQSDWK AHQRTCGTRE YKCDCGTIFS RRDCFITHRA FCDALAEENS  120
KVNQGVMANM GSNLQNQMSE PMSSHSMPLS TDTSTSIGMP YFNSFDPKNS LKYLPQELVP  180
IPSKSMNMAG GMFSSSSGTL FGSPRSISST SSLQLSSKGS SGLHYLQDNK NGCQISASAH  240
MSATAMLKEA AQMGATASNS INSPVMQKSF ASSMAGPHDQ LSSIKPPTYG RIQQHNTSYD  300
HLPLHASGQT SMAGINGVGG FSNQPLQRGP QETSQILDTS GTVNSAMNDM EMFTGVFMSN  360
DQNPGFIRNM EQEDSGGSSL IHGRNPLMER NPTGPSRFAG TSIEGGDMMT RDFRGVGGAR  420
PTNLHDQRQQ HQQRLEMEGM SQQQRMPMMN PFQQQPSLRE SAMEKPSIWD V*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	4e-33	60	123	3	66	Zinc finger protein JACKDAW
5b3h_F	4e-33	60	123	3	66	Zinc finger protein JACKDAW
Search in ModeBase

Expression -- Description ? help Back to Top
Source	Description
Uniprot	TISSUE SPECIFICITY: Observed in vegetative tissues. Mainly expressed in hypocotyls, petioles, shoot apices, root tips, and trichomes, and, at low levels, in leaves, stems and flowers. {ECO:0000269\|PubMed:25035403}.

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that acts as a positive regulator of gibberellin (GA) action, homeostasis and signaling. GA converts the GAF1 complex from transcriptional activator to repressor via the degradation of DELLA proteins. {ECO:0000269\|PubMed:25035403}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Potri.014G132700.1

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_011033580.1	0.0	PREDICTED: zinc finger protein NUTCRACKER-like
Swissprot	Q9SCQ6	1e-71	IDD2_ARATH; Zinc finger protein GAI-ASSOCIATED FACTOR 1
TrEMBL	A0A3N7FC77	0.0	A0A3N7FC77_POPTR; Uncharacterized protein
STRING	POPTR_0014s12720.1	0.0	(Populus trichocarpa)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF2192	30	85
Representative plant	OGRP95	16	242

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G03840.2	5e-61	C2H2 family protein

Link Out ? help Back to Top
Phytozome	Potri.014G132700.1
Entrez Gene	7457954

Publications ? help Back to Top
Fukazawa J, et al. DELLAs function as coactivators of GAI-ASSOCIATED FACTOR1 in regulation of gibberellin homeostasis and signaling in Arabidopsis. Plant Cell, 2014. 26(7): p. 2920-38 [PMID:25035403] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755] Khare D, et al. Root avoidance of toxic metals requires the GeBP-LIKE 4 transcription factor in Arabidopsis thaliana. New Phytol., 2017. 213(3): p. 1257-1273 [PMID:27768815]