PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID PK00080.1
Organism
Cannabis sativa
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Rosales; Cannabaceae; Cannabis
Family E2F/DP
Protein Properties Length: 386aa    MW: 43624.9 Da    PI: 8.4155
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
PK00080.1genomeCCBRView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP71.21.2e-222186171
    E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
               rk+ksL+ll+++fl l+++   + + l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  PK00080.1 21 RKQKSLGLLCSNFLCLYNRDGITSIGLDDAASRL---GV--ERRRIYDIVNVLESVGVLARKAKNQYTWKG 86
               79*****************999************...**..****************************98 PP
2E2F_TDP75.84.2e-24156236171
    E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                r+eksL lltq+f+kl+ +++ + ++l+e+ak L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  PK00080.1 156 RREKSLALLTQNFVKLFVCTSVDLISLDEAAKLLLGDahnssIMRTKVRRLYDIANVLSSMNLIEKthtsdTRKPAFRWLG 236
                689**************************************999**************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.104.6E-251788IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467851.14E-152084IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.9E-272186IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.0E-192286IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.103.6E-22152237IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013727.2E-31156236IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023193.8E-19158236IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467851.14E-13158237IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 386 aa     Download sequence    Send to blast
MAAPPPTVTG GDSSKHHAYS RKQKSLGLLC SNFLCLYNRD GITSIGLDDA ASRLGVERRR  60
IYDIVNVLES VGVLARKAKN QYTWKGFEAI PKALKELKDE GLKENFSSFD GNDDSKVSDD  120
EEDDERISDT RTESQPDKLN HSLNLKSSAS SKPENRREKS LALLTQNFVK LFVCTSVDLI  180
SLDEAAKLLL GDAHNSSIMR TKVRRLYDIA NVLSSMNLIE KTHTSDTRKP AFRWLGFGGR  240
GQAEHNVSAH ESVVTESKKR PFGADITNIS FKRNKLDLGE SLNMNFSKQK QVKQESYVDE  300
IDRITFDEDS NESTKSYQFG PFAPVTIARV GTSENNPRKV HDLEKLATIY RPQYQNQALK  360
DLFSHYMEAW KTWYSEVSEK NPIRIS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-41202283228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_010111971.10.0E2F transcription factor-like E2FE
SwissprotQ8LSZ41e-141E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLW9SXR30.0W9SXR3_9ROSA; E2F transcription factor-like E2FE
STRINGXP_010111971.10.0(Morus notabilis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-141DP-E2F-like 1
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]