PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Ote100167300041
Organism
Ocimum tenuiflorum
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Lamiaceae; Nepetoideae; Ocimeae; Ocimum
Family E2F/DP
Protein Properties Length: 379aa    MW: 42669.7 Da    PI: 9.3303
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Ote100167300041genomeOteDB-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP73.72e-232994171
                       E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                                  rk+ksL+ll+++fl+l+ +   +++ l+++a++L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Ote100167300041|100167300041 29 RKQKSLGLLCSNFLSLYDRNGVETIGLDDAASRL---GV--ERRRIYDIVNVLESVGILTRKAKNRYTWKG 94
                                  79*****************999************...**..****************************98 PP
2E2F_TDP58.98e-19156237171
                       E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse......dvknkrRRiYDilNVLealnliek.....kekneirwk 70 
                                   rkeksL+lltq+f+kl+ +++ +  ++       + +       +++k+RR+YDi+NVL++++ iek     ++k+++rwk
  Ote100167300041|100167300041 156 RKEKSLGLLTQNFVKLFLCTDVNGYDFTXXXXXXLGDgkhtsmTTRTKVRRLYDIANVLSSMKFIEKthhpdTRKPAFRWK 236
                                   79*****************9999999999988888999***99999**********************************9 PP

                       E2F_TDP  71 g 71 
                                   g
  Ote100167300041|100167300041 237 G 237
                                   8 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.3E-262795IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467852.08E-162992IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013721.5E-282994IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023196.4E-213094IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.102.4E-19152238IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013724.3E-22156237IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023195.1E-14157237IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467853.81E-10158238IPR011991Winged helix-turn-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 379 aa     Download sequence    Send to blast
MGEIQLKKEM TLTSPQATES GSKDMPYCRK QKSLGLLCSN FLSLYDRNGV ETIGLDDAAS  60
RLGVERRRIY DIVNVLESVG ILTRKAKNRY TWKGFGAIPN ALENLKKEGL RENGPADTNY  120
SEKISDDEED EMCSDMNSLS QTDRSYSSSV PKRDSRKEKS LGLLTQNFVK LFLCTDVNGY  180
DFTXXXXXXL GDGKHTSMTT RTKVRRLYDI ANVLSSMKFI EKTHHPDTRK PAFRWKGPGA  240
KPDYMSGDSL ISSDHKKRIF GTDLTNATMK RLKVDEGTFQ FLKPHNGVRV KHEKQNEEER  300
IGAVAKSYEF GPFAPANVAK VGECGDGKGK QSVDWESLAS SYRPQYRNQA LKDLFSHFVD  360
AWKSWCSEVA GKGPIQLIS
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A1e-29292294228Transcription factor E2F8
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_011071778.10.0E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-107E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A4D9C2N70.0A0A4D9C2N7_SALSN; Transcription factor E2F7/8
STRINGMigut.I00063.1.p0.0(Erythranthe guttata)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA25222457
Publications ? help Back to Top
  1. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  2. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  3. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]