PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Oryzoideae; Oryzeae; Oryzinae; Oryza

Family

E2F/DP

Protein Properties

Length: 441aa MW: 48658.7 Da PI: 4.7851

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
OPUNC04G10160.1	genome	OGE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	82.8	2.8e-26	89	154	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++ll+++++g+++ln++ak L dv ++RRiYDi+NVLe+ +liekk kn+irw+g OPUNC04G10160.1 89 RYDNSLGLLTRKFINLLKQAQDGTLDLNDAAKIL---DV--RKRRIYDITNVLEGTGLIEKKLKNRIRWRG 154 689*****************************.....9***************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	6.5E-27	86	155	IPR011991	Winged helix-turn-helix DNA-binding domain
SuperFamily	SSF46785	2.89E-17	89	152	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.7E-33	89	154	IPR003316	E2F/DP family, winged-helix DNA-binding domain
Pfam	PF02319	1.2E-23	91	154	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	1.00E-39	164	270	No hit	No description
SuperFamily	SSF144074	1.15E-29	166	270	No hit	No description
Pfam	PF16421	6.3E-27	169	268	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 441 aa Download sequence Send to blast
MSGGGRPPAA QHIVQSVQRF VPLPPARTTP FAAAPGDYHR FVAASRGGEI EEGIVIRTPL 60 KRKTPCGESE AAESSERSPG NPSTPASSRY DNSLGLLTRK FINLLKQAQD GTLDLNDAAK 120 ILDVRKRRIY DITNVLEGTG LIEKKLKNRI RWRGSDDSGT IFDSDISCLK TVVENLYIQE 180 QALDRSISEI REKMEELTED ESNHRWLFVT EDDIKGLPCF QNEALIAIKG PHGTTVEVPD 240 PDEAGDYLQR RYRILLRSTM GPIDLYLVSQ CKKMEELGET AKPPRHASVA EPPSIATEAG 300 QSSKQNMSQN VRQDIQRTPE LNASHAFGRM KKITPSDVDT DADYWLLTDD DISITDMWRT 360 ASEMQWDPID TNNFLAEEIS DTPCALNQPS AADSAYLIDQ SPPFLIFPIQ LATTGVSATV 420 GGNLIGDAAL SCTSTPALMR R

Sequence ? help Back to Top

Protein Sequence Length: 441 aa Download sequence Send to blast

MSGGGRPPAA QHIVQSVQRF VPLPPARTTP FAAAPGDYHR FVAASRGGEI EEGIVIRTPL  60
KRKTPCGESE AAESSERSPG NPSTPASSRY DNSLGLLTRK FINLLKQAQD GTLDLNDAAK  120
ILDVRKRRIY DITNVLEGTG LIEKKLKNRI RWRGSDDSGT IFDSDISCLK TVVENLYIQE  180
QALDRSISEI REKMEELTED ESNHRWLFVT EDDIKGLPCF QNEALIAIKG PHGTTVEVPD  240
PDEAGDYLQR RYRILLRSTM GPIDLYLVSQ CKKMEELGET AKPPRHASVA EPPSIATEAG  300
QSSKQNMSQN VRQDIQRTPE LNASHAFGRM KKITPSDVDT DADYWLLTDD DISITDMWRT  360
ASEMQWDPID TNNFLAEEIS DTPCALNQPS AADSAYLIDQ SPPFLIFPIQ LATTGVSATV  420
GGNLIGDAAL SCTSTPALMR R

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	5e-23	82	154	2	73	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	124	146	RKRRIYDITNVLEGTGLIEKKLK

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Involved in the control of cell-cycle progression from G1 to S phase and from G2 to M phase. Stimulates cell proliferation and delays differentiation. Represses cell enlargement and endoreduplication in auxin-free conditions. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by light and by auxin. May be up-regulated by E2FA. {ECO:0000269\|PubMed:16055635, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:18424613}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK067581	0.0	AK067581.1 Oryza sativa Japonica Group cDNA clone:J013113N12, full insert sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015637107.1	0.0	transcription factor E2FA isoform X2
Swissprot	Q9FV71	2e-94	E2FB_ARATH; Transcription factor E2FB
TrEMBL	A0A0E0KQE9	0.0	A0A0E0KQE9_ORYPU; Uncharacterized protein
STRING	OPUNC04G10160.1	0.0	(Oryza punctata)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP625	37	148

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	2e-97	E2F transcription factor 3

Publications ? help Back to Top
Heyndrickx KS,Vandepoele K Systematic identification of functional plant modules through the integration of complementary data sources. Plant Physiol., 2012. 159(3): p. 884-901 [PMID:22589469] Wu M,Liu L,Hijazi H,Chan C A multi-layer inference approach to reconstruct condition-specific genes and their regulation. Bioinformatics, 2013. 29(12): p. 1541-52 [PMID:23610368] Kobayashi K, et al. Transcriptional repression by MYB3R proteins regulates plant organ growth. EMBO J., 2015. 34(15): p. 1992-2007 [PMID:26069325]