PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Oryzoideae; Oryzeae; Oryzinae; Oryza

Family

E2F/DP

Protein Properties

Length: 448aa MW: 48757.7 Da PI: 4.4092

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
OBART12G03570.1	genome	OGE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	83.3	2e-26	132	197	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kfl+ll+ ++ giv+ln++a++L +v ++RRiYDi+NVLe+++liekk kn+irwkg OBART12G03570.1 132 RYDSSLGLLTKKFLNLLKGAPGGIVDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKKLKNNIRWKG 197 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	8.6E-28	130	198	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	8.6E-35	132	197	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	1.77E-16	132	195	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	1.7E-23	134	197	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	6.26E-49	208	314	No hit	No description
SuperFamily	SSF144074	3.92E-33	209	314	No hit	No description
Pfam	PF16421	1.4E-33	213	312	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 448 aa Download sequence Send to blast
MAAAGAGSSE VAARVLLQRY QPFAPPPGEY HQFGSGGAAA AAAGDMTEAV FIRTPLKRKH 60 DREENEAAES NDWMMSPGYT NPAGSPVPTP LSGKGSKAFA KSKAAKGQKS CPQTPLCASS 120 PGNPVTPVGG CRYDSSLGLL TKKFLNLLKG APGGIVDLNN AAETLEVQKR RIYDITNVLE 180 GIGLIEKKLK NNIRWKGIDD SRPGEVSDDM SILQADIEAL SLQEHSVDQQ ISEMRDKLRG 240 LTEDENNQKW LYVTEDDIKS LPCFQNQTLI AIKAPHGTTL EVPDPDEVND YPQRRYRIVL 300 RSTMGPIDVY LVSQFEEMSG METPPRTVQP VSMDSLENPR TPLAAEPNKA AESQPNIQDG 360 LLMPSDAPSS SQDIGGMMKI VPSELDTDAD YWLLSDAGVS ITDMWKTAPE VEWEGIEKFN 420 AEDFLEVSTP RQQDKPSSDI MDGDSCIS

Sequence ? help Back to Top

Protein Sequence Length: 448 aa Download sequence Send to blast

MAAAGAGSSE VAARVLLQRY QPFAPPPGEY HQFGSGGAAA AAAGDMTEAV FIRTPLKRKH  60
DREENEAAES NDWMMSPGYT NPAGSPVPTP LSGKGSKAFA KSKAAKGQKS CPQTPLCASS  120
PGNPVTPVGG CRYDSSLGLL TKKFLNLLKG APGGIVDLNN AAETLEVQKR RIYDITNVLE  180
GIGLIEKKLK NNIRWKGIDD SRPGEVSDDM SILQADIEAL SLQEHSVDQQ ISEMRDKLRG  240
LTEDENNQKW LYVTEDDIKS LPCFQNQTLI AIKAPHGTTL EVPDPDEVND YPQRRYRIVL  300
RSTMGPIDVY LVSQFEEMSG METPPRTVQP VSMDSLENPR TPLAAEPNKA AESQPNIQDG  360
LLMPSDAPSS SQDIGGMMKI VPSELDTDAD YWLLSDAGVS ITDMWKTAPE VEWEGIEKFN  420
AEDFLEVSTP RQQDKPSSDI MDGDSCIS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	1e-22	121	198	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK059233	0.0	AK059233.1 Oryza sativa Japonica Group cDNA clone:001-024-E10, full insert sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015620749.1	0.0	transcription factor E2FA
Swissprot	Q9FNY0	1e-123	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A0D3HRN4	0.0	A0A0D3HRN4_9ORYZ; Uncharacterized protein
TrEMBL	I1R490	0.0	I1R490_ORYGL; Uncharacterized protein
STRING	ORGLA12G0034600.1	0.0	(Oryza glaberrima)
STRING	OBART12G03570.1	0.0	(Oryza barthii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP625	37	148

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-108	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]