PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; Liliopsida; Petrosaviidae; commelinids; Poales; Poaceae; BOP clade; Oryzoideae; Oryzeae; Oryzinae; Oryza

Family

E2F/DP

Protein Properties

Length: 447aa MW: 48062.8 Da PI: 5.004

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
OBART02G19430.1	genome	OGE	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	85.1	5.6e-27	152	217	1	71
E2F_TDP 1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 r+++sL+llt+kf++ll+++++gi++ln++a++L +v ++RRiYDi+NVLe+++liek+ kn+irwkg OBART02G19430.1 152 RYDSSLGLLTKKFINLLKQAPDGILDLNNAAETL---EV--QKRRIYDITNVLEGIGLIEKTLKNRIRWKG 217 6899****************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.10	8.5E-29	150	219	IPR011991	Winged helix-turn-helix DNA-binding domain
SMART	SM01372	2.0E-35	152	217	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	3.35E-18	152	215	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	2.3E-24	154	217	IPR003316	E2F/DP family, winged-helix DNA-binding domain
CDD	cd14660	8.13E-50	227	333	No hit	No description
SuperFamily	SSF144074	1.18E-34	230	333	No hit	No description
Pfam	PF16421	2.2E-33	232	331	IPR032198	E2F transcription factor, CC-MB domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0008284	Biological Process	positive regulation of cell proliferation
GO:0009733	Biological Process	response to auxin
GO:0010090	Biological Process	trichome morphogenesis
GO:0045893	Biological Process	positive regulation of transcription, DNA-templated
GO:0051302	Biological Process	regulation of cell division
GO:0051446	Biological Process	positive regulation of meiotic cell cycle
GO:0005634	Cellular Component	nucleus
GO:0005667	Cellular Component	transcription factor complex
GO:0005737	Cellular Component	cytoplasm
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 447 aa Download sequence Send to blast
MAGSGRPPAA QKKILQSLRP PLPFAASSRS PFAAPNDYHR FPSGGAAAAA AASGSGGIGA 60 GGAGGGGGDI EEGLVIRTPQ KRKAPEESDV AESSDCMITS PGFTVSPMLT PVSGKAVKTS 120 KSKTKNNKAG PQTPTSNVGS PLNPPTPVGT CRYDSSLGLL TKKFINLLKQ APDGILDLNN 180 AAETLEVQKR RIYDITNVLE GIGLIEKTLK NRIRWKGLDD SGVELDNGLS ALQAEVENLS 240 LKEQALDERI SDMREKLRGL TEDENNQRWL YVTEDDIKGL PCFQNETLIA IKAPHGTTLE 300 VPDPDEAGDY LQRRYRIVLR STMGPIDVYL VSQFDEKFED LGGGATPSGH ANVPKHQPTE 360 VFNTTNAGVG QCSNSVAVDN NIQHSQTIPQ DPSASHDFGG MTRIIPSDID TDADYWLISE 420 GDVSITDMWK TARILYDRSL HFCLDYS

Sequence ? help Back to Top

Protein Sequence Length: 447 aa Download sequence Send to blast

MAGSGRPPAA QKKILQSLRP PLPFAASSRS PFAAPNDYHR FPSGGAAAAA AASGSGGIGA  60
GGAGGGGGDI EEGLVIRTPQ KRKAPEESDV AESSDCMITS PGFTVSPMLT PVSGKAVKTS  120
KSKTKNNKAG PQTPTSNVGS PLNPPTPVGT CRYDSSLGLL TKKFINLLKQ APDGILDLNN  180
AAETLEVQKR RIYDITNVLE GIGLIEKTLK NRIRWKGLDD SGVELDNGLS ALQAEVENLS  240
LKEQALDERI SDMREKLRGL TEDENNQRWL YVTEDDIKGL PCFQNETLIA IKAPHGTTLE  300
VPDPDEAGDY LQRRYRIVLR STMGPIDVYL VSQFDEKFED LGGGATPSGH ANVPKHQPTE  360
VFNTTNAGVG QCSNSVAVDN NIQHSQTIPQ DPSASHDFGG MTRIIPSDID TDADYWLISE  420
GDVSITDMWK TARILYDRSL HFCLDYS

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	1e-23	144	218	2	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AK068689	0.0	AK068689.1 Oryza sativa Japonica Group cDNA clone:J013161I16, full insert sequence.
GenBank	HQ858830	0.0	HQ858830.1 Oryza sativa Japonica Group isolate UT1329 E2F-DP transcription factor mRNA, partial cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_015623378.1	0.0	transcription factor E2FB
Swissprot	Q9FNY0	1e-129	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A0D3F626	0.0	A0A0D3F626_9ORYZ; Uncharacterized protein
STRING	OBART02G19430.1	0.0	(Oryza barthii)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Monocots	OGMP625	37	148

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-121	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]