PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Niben101Scf08137g05001.1
Organism
Nicotiana benthamiana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family HD-ZIP
Protein Properties Length: 714aa    MW: 78915.5 Da    PI: 6.5483
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Niben101Scf08137g05001.1genomeBTI-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox59.26.6e-192479156
                              TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
                  Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                              +++ +++t++q+++Le+ F+++++p++++r +L++ lgL   q+k+WFqNrR+++k
  Niben101Scf08137g05001.1 24 KKRYHRHTANQIQRLESIFKECPHPDEKTRLQLSRDLGLAPHQIKFWFQNRRTQMK 79
                              678899***********************************************998 PP
2START172.13.5e-542224472206
                               HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT- CS
                     START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetl 76 
                               +a  a++el+++++ +ep+W ks+    + +n + + ++f+++++       ++ea+r+sgvv+m+   lv  ++d + +W+e +
  Niben101Scf08137g05001.1 222 IAGNAMEELIRLVQTNEPLWIKSAidgkDVLNFENYDRIFPRANShlknhnVRIEASRDSGVVIMNGLALVDMFMDAN-KWQEFF 305
                               67899*********************999999********9999999*9999**************************.****** PP

                               S....EEEEEEEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSE CS
                     START  77 a....kaetlevissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpS 150
                               +    ka tlevissg      ++lqlm+ elq+lsplvp R  +f+R+++q ++ +w+ivdvS d +q++  s  + ++++lpS
  Niben101Scf08137g05001.1 306 PtivsKARTLEVISSGvmggrmSTLQLMYEELQVLSPLVPtRQLYFLRFCQQIEQSSWAIVDVSYDITQENLYSNTSCKVHRLPS 390
                               **********************************************************************977************ PP

                               EEEEEEECTCEEEEEEEE-EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
                     START 151 giliepksnghskvtwvehvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                               g+li++++ng+skv wvehv+++++ + h l r l++sgla+ga +w  tlqr ce+
  Niben101Scf08137g05001.1 391 GCLIQDMPNGYSKVSWVEHVEVEEKGIiHRLCRDLIHSGLAFGAERWIGTLQRACER 447
                               ***********************99988***************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466891.04E-181081IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.605.3E-211985IPR009057Homeodomain-like
PROSITE profilePS5007117.1192181IPR001356Homeobox domain
SMARTSM003896.8E-182285IPR001356Homeobox domain
CDDcd000867.63E-172382No hitNo description
PfamPF000461.3E-162479IPR001356Homeobox domain
PROSITE patternPS0002705679IPR017970Homeobox, conserved site
PROSITE profilePS5084848.274212450IPR002913START domain
SuperFamilySSF559611.37E-33213449No hitNo description
CDDcd088754.03E-115216446No hitNo description
SMARTSM002346.0E-43221447IPR002913START domain
PfamPF018524.2E-46222447IPR002913START domain
SuperFamilySSF559613.45E-22468703No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 714 aa     Download sequence    Send to blast
MEYGSGGGGG TSSGDPHDAA ERRKKRYHRH TANQIQRLES IFKECPHPDE KTRLQLSRDL  60
GLAPHQIKFW FQNRRTQMKA QHERADNCAV RAENDKIRCE NIAIREALKN VICPSCGGPP  120
VTEDSYFDEQ KLRIENMQLK EELDKVSSIA AKYIGRPISQ LPPVQPIHLS SLDLSMSSFV  180
GHGPNSLDLD LDLLPGSSSS ISNLAFSSLN LSDMDKSLMA DIAGNAMEEL IRLVQTNEPL  240
WIKSAIDGKD VLNFENYDRI FPRANSHLKN HNVRIEASRD SGVVIMNGLA LVDMFMDANK  300
WQEFFPTIVS KARTLEVISS GVMGGRMSTL QLMYEELQVL SPLVPTRQLY FLRFCQQIEQ  360
SSWAIVDVSY DITQENLYSN TSCKVHRLPS GCLIQDMPNG YSKVSWVEHV EVEEKGIIHR  420
LCRDLIHSGL AFGAERWIGT LQRACERYAC LMVNSNRTQD LGGVIPSPEG KRSMMKLAKR  480
MVSNFCGSIN PSNGHQWNTI SGLNEFEVRA TLQKSTDPGQ PNGVIISAAT TIWLPVPPQN  540
VFNFFRDERT RPQWDVLSNQ NPVQEVAHIA NGSHPGNCIS VLRAYNTSQN NMLILQESCI  600
DSSGALIVYS PVDVPAINIA MSGEDPTYIP LLPSGFTISP DGHQLDQDAA SCSSSSNAST  660
IGGRSGSSLI TVVFQILVSS LPSAKMSPES VNTVNNLIGS TVHQIKAALN CSTS
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_019225984.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A314KSY20.0A0A314KSY2_NICAT; Homeobox-leucine zipper protein hdg11
STRINGXP_009786509.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA24902351
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]