PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Niben101Scf05146g05002.1
Organism
Nicotiana benthamiana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family HD-ZIP
Protein Properties Length: 725aa    MW: 80086 Da    PI: 6.4613
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Niben101Scf05146g05002.1genomeBTI-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox60.72.2e-192677556
                              SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
                  Homeobox  5 ttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                              +++t++q++ Le++F+++++p++++r +L+k+lgL  rq+k+WFqNrR++ k
  Niben101Scf05146g05002.1 26 HRHTAHQIQNLEAVFKECPHPDEKSRLQLSKELGLAPRQIKFWFQNRRTQLK 77
                              689*********************************************9987 PP
2START173.51.4e-542234482206
                               HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT- CS
                     START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetl 76 
                               +a  a++el+++ + +ep+W+ks     + ++ d + q+f+++++       ++ea+r+sgvv+m+   lv+ ++d + +W e +
  Niben101Scf05146g05002.1 223 IAGNAMEELIRLLQTDEPLWTKSTtdgrDVLDLDSYNQIFPRANSslknsnVRVEASRDSGVVIMNGLALVNMFMDAN-KWMEFF 306
                               67899********************99999***********9999****999**************************.**9999 PP

                               S....EEEEEEEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSE CS
                     START  77 a....kaetlevissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpS 150
                               +    ka t+evis g      ++lqlm+ e+q+lsplvp R + f+R+++q  +g+w+ivdvS d  q+++  ss+  +++lpS
  Niben101Scf05146g05002.1 307 PttvsKARTIEVISCGviggrsSTLQLMYEEMQVLSPLVPtRQSFFLRFCQQIDQGSWAIVDVSYDIIQENQYPSSSYMVHRLPS 391
                               99999***********************************************************9999999885566668***** PP

                               EEEEEEECTCEEEEEEEE-EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
                     START 151 giliepksnghskvtwvehvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                               g+li++++ng+skvtwvehv+++++   h l+r l++sg+a+ga +w+  lqr+ce+
  Niben101Scf05146g05002.1 392 GCLIQDMPNGYSKVTWVEHVEVEEKGLiHKLYRDLIHSGMAFGAERWLGSLQRLCER 448
                               **********************987555***************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.609.1E-21873IPR009057Homeodomain-like
SuperFamilySSF466896.27E-19879IPR009057Homeodomain-like
PROSITE profilePS5007117.3941979IPR001356Homeobox domain
SMARTSM003891.8E-182083IPR001356Homeobox domain
CDDcd000863.07E-182180No hitNo description
PfamPF000466.5E-172677IPR001356Homeobox domain
PROSITE patternPS0002705477IPR017970Homeobox, conserved site
PROSITE profilePS5084847.808213451IPR002913START domain
SuperFamilySSF559615.17E-36214450No hitNo description
CDDcd088752.59E-112217447No hitNo description
SMARTSM002344.5E-43222448IPR002913START domain
PfamPF018521.4E-46223448IPR002913START domain
SuperFamilySSF559614.34E-20469690No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008289Molecular Functionlipid binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 725 aa     Download sequence    Send to blast
MEYGGVTSSS GGGDASETHR KKKRFHRHTA HQIQNLEAVF KECPHPDEKS RLQLSKELGL  60
APRQIKFWFQ NRRTQLKSQH ERADNCALRA ENDRIRCENI AIREAIKNVI CPSCGGPPVT  120
EDSYFDEHKL RMENMQLKEE LDKISSIAAK YIGRPISQLP PVQPIHLSSL NLMSMSSFGG  180
IGLTGPSLDL DLLPVNSMST TIPSLPFPTL NISDMDKSLM ADIAGNAMEE LIRLLQTDEP  240
LWTKSTTDGR DVLDLDSYNQ IFPRANSSLK NSNVRVEASR DSGVVIMNGL ALVNMFMDAN  300
KWMEFFPTTV SKARTIEVIS CGVIGGRSST LQLMYEEMQV LSPLVPTRQS FFLRFCQQID  360
QGSWAIVDVS YDIIQENQYP SSSYMVHRLP SGCLIQDMPN GYSKVTWVEH VEVEEKGLIH  420
KLYRDLIHSG MAFGAERWLG SLQRLCERYA CLVVSGKSSR ELGGVIPSPE GKKSMMKLAQ  480
RMVSNFCASI NPSNGHQWNT ISGLDEFEVR ATLQKSTDPG QPNGVIISAA STIWLPVPSQ  540
HVFNFLKDER TRPQWDVLSN QNPVQEVAHI ANGSHPGNCI SVLRAYNTSQ NNMLILQESC  600
IDSSGSLVIY SPVDLPSINM AMSGEDTTYI PLLPSGFTIS PDGRQGQRSN EASCSSTNNG  660
TMGDNGSEGS LVTVVFQILV SIVFQILVSS LSSSAKMSPE SVNTVNNLIG NTIHQIKAAL  720
NCSTS
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_016451582.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A1S3YI130.0A0A1S3YI13_TOBAC; homeobox-leucine zipper protein HDG11-like
STRINGXP_009778533.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA24902351
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]