PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

NAC

Protein Properties

Length: 451aa MW: 51231.8 Da PI: 9.4556

Description

NAC family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Niben101Scf04745g02009.1	genome	BTI	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	NAM	179.1	1.2e-55	14	141	1	128
NAM 1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratksgyWka 85 lppGfrFhPtdeel+++yL kkv + ++++ ++i+evd++k+ePw+Lp k+k +ekewyfFs rd+ky+tg r+nrat++gyWka Niben101Scf04745g02009.1 14 LPPGFRFHPTDEELITYYLLKKVLDGNFTA-RAIAEVDLNKCEPWELPGKAKMGEKEWYFFSLRDRKYPTGLRTNRATEAGYWKA 97 79***********************999.89***********99999**************************** PP NAM 86 tgkdkevlsk.kgelvglkktLvfykgrapkgektdWvmheyrl 128 tgkd+e++s+ + +lvg+kktLvfy+grapkgek++Wvmheyrl Niben101Scf04745g02009.1 98 TGKDREIYSSkTCALVGMKKTLVFYRGRAPKGEKSNWVMHEYRL 141 ****9745567*************************98 PP
2	NAM	136.5	1.7e-42	148	261	17	128
NAM 17 eyLkk..kvegkkleleevikevdiykvePwdLpkkvkaeekewyfFskrdkkyatgkrknratksgyWkatgkdkevlsk.kge 98 +y+ + kv + ++++ ++i+evd++k+ePw+Lp k+k +ekewyfFs rd+ky+tg r+nrat++gyWkatgkd+e++s+ + + Niben101Scf04745g02009.1 148 HYISRssKVLDGNFTA-RAIAEVDLNKCEPWELPGKAKMGEKEWYFFSLRDRKYPTGLRTNRATEAGYWKATGKDREIYSSkTCA 231 5665511455555666.78*************99999************************************974556 PP NAM 99 lvglkktLvfykgrapkgektdWvmheyrl 128 lvg+kktLvfy+grapkgek++Wvmheyrl Niben101Scf04745g02009.1 232 LVGMKKTLVFYRGRAPKGEKSNWVMHEYRL 261 7*************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF101941	4.18E-60	12	149	IPR003441	NAC domain
PROSITE profile	PS51005	55.786	14	163	IPR003441	NAC domain
Pfam	PF02365	1.2E-28	15	141	IPR003441	NAC domain
SuperFamily	SSF101941	2.35E-48	154	286	IPR003441	NAC domain
PROSITE profile	PS51005	38.681	166	286	IPR003441	NAC domain
Pfam	PF02365	2.0E-16	175	261	IPR003441	NAC domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0003677	Molecular Function	DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 451 aa Download sequence Send to blast
MDNYQHFDCS DGNLPPGFRF HPTDEELITY YLLKKVLDGN FTARAIAEVD LNKCEPWELP 60 GKAKMGEKEW YFFSLRDRKY PTGLRTNRAT EAGYWKATGK DREIYSSKTC ALVGMKKTLV 120 FYRGRAPKGE KSNWVMHEYR LDGKFAYHYI SRSSKVLDGN FTARAIAEVD LNKCEPWELP 180 GKAKMGEKEW YFFSLRDRKY PTGLRTNRAT EAGYWKATGK DREIYSSKTC ALVGMKKTLV 240 FYRGRAPKGE KSNWVMHEYR LDGKFAYHYI SRSSKDEWVI SRVFQKNGST VGGNKKRLSS 300 SINMYQEVSS PSSVSQLPPL LDSSPYSTTA SSAVINADRE SFKKEHVPCF STTATHSFDP 360 TSSVFDISSN SLHALPPPSF SAILDSSTNF THYTRNSTFP SLRSLHENLQ LPLFSSGAPA 420 MHGGFSASMA NWPVPEAQKV EQSELDCMWG Y

Sequence ? help Back to Top

Protein Sequence Length: 451 aa Download sequence Send to blast

MDNYQHFDCS DGNLPPGFRF HPTDEELITY YLLKKVLDGN FTARAIAEVD LNKCEPWELP  60
GKAKMGEKEW YFFSLRDRKY PTGLRTNRAT EAGYWKATGK DREIYSSKTC ALVGMKKTLV  120
FYRGRAPKGE KSNWVMHEYR LDGKFAYHYI SRSSKVLDGN FTARAIAEVD LNKCEPWELP  180
GKAKMGEKEW YFFSLRDRKY PTGLRTNRAT EAGYWKATGK DREIYSSKTC ALVGMKKTLV  240
FYRGRAPKGE KSNWVMHEYR LDGKFAYHYI SRSSKDEWVI SRVFQKNGST VGGNKKRLSS  300
SINMYQEVSS PSSVSQLPPL LDSSPYSTTA SSAVINADRE SFKKEHVPCF STTATHSFDP  360
TSSVFDISSN SLHALPPPSF SAILDSSTNF THYTRNSTFP SLRSLHENLQ LPLFSSGAPA  420
MHGGFSASMA NWPVPEAQKV EQSELDCMWG Y

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1ut4_A	9e-49	13	289	16	168	NO APICAL MERISTEM PROTEIN
1ut4_B	9e-49	13	289	16	168	NO APICAL MERISTEM PROTEIN
1ut7_A	9e-49	13	289	16	168	NO APICAL MERISTEM PROTEIN
1ut7_B	9e-49	13	289	16	168	NO APICAL MERISTEM PROTEIN
4dul_A	9e-49	13	289	16	168	NAC domain-containing protein 19
4dul_B	9e-49	13	289	16	168	NAC domain-containing protein 19
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator of STM and KNAT6. Involved in molecular mechanisms regulating shoot apical meristem (SAM) formation during embryogenesis and organ separation. Required for the fusion of septa of gynoecia along the length of the ovaries. Activates the shoot formation in callus in a STM-dependent manner. Controls leaf margin development and required for leaf serration. Involved in axillary meristem initiation and separation of the meristem from the main stem. Regulates the phyllotaxy throughout the plant development. Seems to act as an inhibitor of cell division. {ECO:0000269\|PubMed:10079219, ECO:0000269\|PubMed:10750709, ECO:0000269\|PubMed:12163400, ECO:0000269\|PubMed:12492830, ECO:0000269\|PubMed:12610213, ECO:0000269\|PubMed:15202996, ECO:0000269\|PubMed:15294871, ECO:0000269\|PubMed:15500463, ECO:0000269\|PubMed:15723790, ECO:0000269\|PubMed:16798887, ECO:0000269\|PubMed:17098808, ECO:0000269\|PubMed:17122068, ECO:0000269\|PubMed:17251269, ECO:0000269\|PubMed:17287247, ECO:0000269\|PubMed:9212461}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By BRM and SYD, at the chromatin level, and conferring a very specific spatial expression pattern. Precise spatial regulation by post-transcriptional repression directed by the microRNA miR164. {ECO:0000269\|PubMed:15202996, ECO:0000269\|PubMed:15294871, ECO:0000269\|PubMed:15723790, ECO:0000269\|PubMed:16854978, ECO:0000269\|PubMed:17251269, ECO:0000269\|PubMed:17287247}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_016509208.1	0.0	PREDICTED: protein CUP-SHAPED COTYLEDON 2-like
Swissprot	O04017	9e-96	NAC98_ARATH; Protein CUP-SHAPED COTYLEDON 2
TrEMBL	A0A1S4D790	0.0	A0A1S4D790_TOBAC; protein CUP-SHAPED COTYLEDON 2-like
STRING	XP_009615029.1	0.0	(Nicotiana tomentosiformis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA152	24	279

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G53950.1	9e-96	NAC family protein

Publications ? help Back to Top
Wang YX Characterization of a novel Medicago sativa NAC transcription factor gene involved in response to drought stress. Mol. Biol. Rep., 2013. 40(11): p. 6451-8 [PMID:24057250] Kamiuchi Y,Yamamoto K,Furutani M,Tasaka M,Aida M The CUC1 and CUC2 genes promote carpel margin meristem formation during Arabidopsis gynoecium development. Front Plant Sci, 2014. 5: p. 165 [PMID:24817871] Gonçalves B, et al. A conserved role for CUP-SHAPED COTYLEDON genes during ovule development. Plant J., 2015. 83(4): p. 732-42 [PMID:26119568] Du Q,Wang H The role of HD-ZIP III transcription factors and miR165/166 in vascular development and secondary cell wall formation. Plant Signal Behav, 2015. 10(10): p. e1078955 [PMID:26340415] Vialette-Guiraud AC, et al. A Conserved Role for the NAM/miR164 Developmental Module Reveals a Common Mechanism Underlying Carpel Margin Fusion in Monocarpous and Syncarpous Eurosids. Front Plant Sci, 2015. 6: p. 1239 [PMID:26793217] Cui X, et al. REF6 recognizes a specific DNA sequence to demethylate H3K27me3 and regulate organ boundary formation in Arabidopsis. Nat. Genet., 2016. 48(6): p. 694-9 [PMID:27111035] Blein T,Pautot V,Laufs P Combinations of Mutations Sufficient to Alter Arabidopsis Leaf Dissection. Plants (Basel), 2013. 2(2): p. 230-47 [PMID:27137374] Biot E, et al. Multiscale quantification of morphodynamics: MorphoLeaf software for 2D shape analysis. Development, 2016. 143(18): p. 3417-28 [PMID:27387872] Zheng M, et al. Chloroplast Translation Initiation Factors Regulate Leaf Variegation and Development. Plant Physiol., 2016. 172(2): p. 1117-1130 [PMID:27535792] Balkunde R,Kitagawa M,Xu XM,Wang J,Jackson D SHOOT MERISTEMLESS trafficking controls axillary meristem formation, meristem size and organ boundaries in Arabidopsis. Plant J., 2017. 90(3): p. 435-446 [PMID:28161901] Koyama T,Sato F,Ohme-Takagi M Roles of miR319 and TCP Transcription Factors in Leaf Development. Plant Physiol., 2017. 175(2): p. 874-885 [PMID:28842549] González-Carranza ZH, et al. HAWAIIAN SKIRT controls size and floral organ number by modulating CUC1 and CUC2 expression. PLoS ONE, 2017. 12(9): p. e0185106 [PMID:28934292] Wilson-Sánchez D,Martínez-López S,Navarro-Cartagena S,Jover-Gil S,Micol JL Members of the DEAL subfamily of the DUF1218 gene family are required for bilateral symmetry but not for dorsoventrality in Arabidopsis leaves. New Phytol., 2018. 217(3): p. 1307-1321 [PMID:29139551] Gonçalves B, et al. GDP-L-fucose is required for boundary definition in plants. J. Exp. Bot., 2017. 68(21-22): p. 5801-5811 [PMID:29186469] Sha S, et al. To be serrate or pinnate: diverse leaf forms of yarrows (Achillea) are linked to differential expression patterns of NAM genes. Ann. Bot., 2018. 121(2): p. 255-266 [PMID:29267935] Maugarny-Calès A, et al. Dissecting the pathways coordinating patterning and growth by plant boundary domains. PLoS Genet., 2019. 15(1): p. e1007913 [PMID:30677017]