PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

AP2

Protein Properties

Length: 520aa MW: 57327.5 Da PI: 6.0531

Description

AP2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Niben101Scf04386g00002.1	genome	BTI	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	AP2	35.7	2.2e-11	174	230	1	55
AP2 1 sgykGVrwdkkrgrWvAeIrd.pseng..kr.krfslgkfgtaeeAakaaiaarkkleg 55 s y+GV++++++gr++A+++d + ++ k + g ++ +e+Aa+a++ a++k++g Niben101Scf04386g00002.1 174 SIYRGVTRHRWTGRYEAHLWDnSCR-RegQSrKGRQ-GGYDKEEKAARAYDLAALKYWG 230 57*****************5444.2455536655.779999************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Pfam	PF00847	8.5E-9	174	230	IPR001471	AP2/ERF domain
CDD	cd00018	3.94E-20	174	240	No hit	No description
SuperFamily	SSF54171	7.19E-15	174	240	IPR016177	DNA-binding domain
SMART	SM00380	3.2E-23	175	244	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	17.504	175	238	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	3.1E-12	175	239	IPR001471	AP2/ERF domain
PRINTS	PR00367	3.3E-6	176	187	IPR001471	AP2/ERF domain
PROSITE profile	PS51032	10.296	227	303	IPR001471	AP2/ERF domain
SMART	SM00380	4.1E-5	249	309	IPR001471	AP2/ERF domain
Gene3D	G3DSA:3.30.730.10	1.0E-6	256	303	IPR001471	AP2/ERF domain
SuperFamily	SSF54171	2.68E-5	275	304	IPR016177	DNA-binding domain
PRINTS	PR00367	3.3E-6	285	305	IPR001471	AP2/ERF domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0000723	Biological Process	telomere maintenance
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0007389	Biological Process	pattern specification process
GO:0010073	Biological Process	meristem maintenance
GO:0010449	Biological Process	root meristem growth
GO:0019827	Biological Process	stem cell population maintenance
GO:0003677	Molecular Function	DNA binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 520 aa Download sequence Send to blast
MNSNNWLSFP LSPTHSSLPP HLQTTQSHHF TLGLVNETID NPFQNQEWNL MNTQGSNEVP 60 KVADFLGVNK SDENQSELVH YNEIQPNDSD YLFQNNSLMP MHNALAPTGN YELQENACNI 120 QSLTLSMGSG KGSTSETSAS PSAITTANAS ENSNTSIVEA APRRTLDTFG QRTSIYRGVT 180 RHRWTGRYEA HLWDNSCRRE GQSRKGRQGG YDKEEKAARA YDLAALKYWG TSTTTNFPIS 240 NYEKELEDMK HMTRQEFVAA IRRKSSGFSR GASMYRATEE EAAEAYDIAA IKFRGLNAVT 300 NFDMNRYDVK AILESNTLPI GGGAAKRLKE AQALESSRKR DQEMIALNSS FQYGNSSNSS 360 NNPLHAYPLL QQQPFSIESH QPLMTLQNQE SSHFHQSYLQ TQLQLHPAAQ TGHYDSSTHQ 420 FYNNYLQSNP VFLHGLMENG GGSSSTGSYS TGGYFGNTTG LGGISSNSTS NGVGGGNGEE 480 VALVKVDYDN IPVNGSNYNG WSGDSSVQGT NPGVFSMWND

Sequence ? help Back to Top

Protein Sequence Length: 520 aa Download sequence Send to blast

MNSNNWLSFP LSPTHSSLPP HLQTTQSHHF TLGLVNETID NPFQNQEWNL MNTQGSNEVP  60
KVADFLGVNK SDENQSELVH YNEIQPNDSD YLFQNNSLMP MHNALAPTGN YELQENACNI  120
QSLTLSMGSG KGSTSETSAS PSAITTANAS ENSNTSIVEA APRRTLDTFG QRTSIYRGVT  180
RHRWTGRYEA HLWDNSCRRE GQSRKGRQGG YDKEEKAARA YDLAALKYWG TSTTTNFPIS  240
NYEKELEDMK HMTRQEFVAA IRRKSSGFSR GASMYRATEE EAAEAYDIAA IKFRGLNAVT  300
NFDMNRYDVK AILESNTLPI GGGAAKRLKE AQALESSRKR DQEMIALNSS FQYGNSSNSS  360
NNPLHAYPLL QQQPFSIESH QPLMTLQNQE SSHFHQSYLQ TQLQLHPAAQ TGHYDSSTHQ  420
FYNNYLQSNP VFLHGLMENG GGSSSTGSYS TGGYFGNTTG LGGISSNSTS NGVGGGNGEE  480
VALVKVDYDN IPVNGSNYNG WSGDSSVQGT NPGVFSMWND

Functional Description ? help Back to Top
Source	Description
UniProt	Probably acts as a transcriptional activator. Binds to the GCC-box pathogenesis-related promoter element. May be involved in the regulation of gene expression by stress factors and by components of stress signal transduction pathways (By similarity). Master regulator of basal/root fate. Essential for root quiescent center (QC) and columella specification, stem cell activity, as well as for establishment of the stem cell niche during embryogenesis. Modulates the root polar auxin transport by regulating the distribution of PIN genes. Essential role in respecifying pattern and polarity in damaged roots. Direct target of the transcriptional corepressor TPL. Expression levels and patterns regulated post-transcriptionally by root meristem growth factors (RGFs). {ECO:0000250, ECO:0000269\|PubMed:15454085, ECO:0000269\|PubMed:15635403, ECO:0000269\|PubMed:16424342, ECO:0000269\|PubMed:20190735}.

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By auxin accumulation. {ECO:0000269\|PubMed:15454085}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_019237246.1	0.0	PREDICTED: AP2-like ethylene-responsive transcription factor PLT2 isoform X2
Swissprot	Q5YGP7	0.0	PLET2_ARATH; AP2-like ethylene-responsive transcription factor PLT2
TrEMBL	A0A1J6KIB9	0.0	A0A1J6KIB9_NICAT; Ap2-like ethylene-responsive transcription factor plt2
STRING	XP_009801579.1	0.0	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA2246	24	57

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G51190.1	1e-180	AP2 family protein

Publications ? help Back to Top
Duarte JM, et al. Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol. Biol. Evol., 2006. 23(2): p. 469-78 [PMID:16280546] Lee DK,Sieburth LE The bps signal: embryonic arrest from an auxin-independent mechanism in bypass triple mutants. Plant Signal Behav, 2012. 7(6): p. 698-700 [PMID:22580686] Hong LW,Yan DW,Liu WC,Chen HG,Lu YT TIME FOR COFFEE controls root meristem size by changes in auxin accumulation in Arabidopsis. J. Exp. Bot., 2014. 65(1): p. 275-86 [PMID:24277277] Tian H,Jia Y,Niu T,Yu Q,Ding Z The key players of the primary root growth and development also function in lateral roots in Arabidopsis. Plant Cell Rep., 2014. 33(5): p. 745-53 [PMID:24504658] Zhao Q, et al. Sulfur nutrient availability regulates root elongation by affecting root indole-3-acetic acid levels and the stem cell niche. J Integr Plant Biol, 2014. 56(12): p. 1151-63 [PMID:24831283] Huang JB, et al. ROP3 GTPase contributes to polar auxin transport and auxin responses and is important for embryogenesis and seedling growth in Arabidopsis. Plant Cell, 2014. 26(9): p. 3501-18 [PMID:25217509] Yang S, et al. The Arabidopsis SWI2/SNF2 Chromatin Remodeling ATPase BRAHMA Targets Directly to PINs and Is Required for Root Stem Cell Niche Maintenance. Plant Cell, 2015. 27(6): p. 1670-80 [PMID:25991732] Jia Y, et al. The Arabidopsis thaliana elongator complex subunit 2 epigenetically affects root development. J. Exp. Bot., 2015. 66(15): p. 4631-42 [PMID:25998905] Zhang M, et al. A tetratricopeptide repeat domain-containing protein SSR1 located in mitochondria is involved in root development and auxin polar transport in Arabidopsis. Plant J., 2015. 83(4): p. 582-99 [PMID:26072661] Shinohara H,Mori A,Yasue N,Sumida K,Matsubayashi Y Identification of three LRR-RKs involved in perception of root meristem growth factor in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A., 2016. 113(14): p. 3897-902 [PMID:27001831] Ou Y, et al. RGF1 INSENSITIVE 1 to 5, a group of LRR receptor-like kinases, are essential for the perception of root meristem growth factor 1 in Arabidopsis thaliana. Cell Res., 2016. 26(6): p. 686-98 [PMID:27229312] Santuari L, et al. The PLETHORA Gene Regulatory Network Guides Growth and Cell Differentiation in Arabidopsis Roots. Plant Cell, 2016. 28(12): p. 2937-2951 [PMID:27920338] Promchuea S,Zhu Y,Chen Z,Zhang J,Gong Z ARF2 coordinates with PLETHORAs and PINs to orchestrate ABA-mediated root meristem activity in Arabidopsis . J Integr Plant Biol, 2017. 59(1): p. 30-43 [PMID:28074634] Du Y,Scheres B PLETHORA transcription factors orchestrate de novo organ patterning during Arabidopsis lateral root outgrowth. Proc. Natl. Acad. Sci. U.S.A., 2017. 114(44): p. 11709-11714 [PMID:29078398] Bustillo-Avendaño E, et al. Regulation of Hormonal Control, Cell Reprogramming, and Patterning during De Novo Root Organogenesis. Plant Physiol., 2018. 176(2): p. 1709-1727 [PMID:29233938]