PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Niben101Scf02108g00002.1
Organism
Nicotiana benthamiana
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana
Family HD-ZIP
Protein Properties Length: 718aa    MW: 79181 Da    PI: 6.5483
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Niben101Scf02108g00002.1genomeBTI-
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox60.52.6e-192883156
                              TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
                  Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                              +++ +++t++q+++Le+ F+++++p++++r +L++ lgL  rq+k+WFqNrR+++k
  Niben101Scf02108g00002.1 28 KKRYHRHTANQIQRLESIFKECPHPDEKTRLQLSRDLGLAPRQIKFWFQNRRTQMK 83
                              678899***********************************************998 PP
2START177.48.5e-562264512206
                               HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT- CS
                     START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetl 76 
                               +a  a++el+++++ +ep+W+ks+    + +n + + ++f+++++       ++ea+r+sgvv+m+  +lv  ++d + +W+e +
  Niben101Scf02108g00002.1 226 IAGNAMDELIRLVQTNEPLWMKSAidgkDVLNFENYDRIFPRANShlknhnVRIEASRDSGVVIMNGLTLVDMFMDAN-KWQEFF 309
                               67899*********************999999********9999999*9999**************************.****** PP

                               S....EEEEEEEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSE CS
                     START  77 a....kaetlevissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpS 150
                               +    ka tlevissg      ++lqlm+ elq+lsplvp R  +f+R+++q ++  w+ivdvS d +q++  ss + ++++lpS
  Niben101Scf02108g00002.1 310 PtivsKARTLEVISSGvmgsrmSTLQLMYEELQVLSPLVPtRQLYFLRFCQQIEQSLWAIVDVSYDITQENLYSSTSCKVHRLPS 394
                               **********************************************************************977************ PP

                               EEEEEEECTCEEEEEEEE-EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
                     START 151 giliepksnghskvtwvehvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                               g+li++++ng+skvtwvehv+++++ + h l r l++sgla+ga +w  tlqr ce+
  Niben101Scf02108g00002.1 395 GCLIQDMPNGYSKVTWVEHVEVEEKGIiHRLCRDLLHSGLAFGAERWIGTLQRVCER 451
                               ***********************99988***************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466892.42E-191185IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.602.2E-212389IPR009057Homeodomain-like
PROSITE profilePS5007117.5082585IPR001356Homeobox domain
SMARTSM003892.3E-182689IPR001356Homeobox domain
CDDcd000867.59E-182786No hitNo description
PfamPF000465.3E-172883IPR001356Homeobox domain
PROSITE patternPS0002706083IPR017970Homeobox, conserved site
PROSITE profilePS5084848.323216454IPR002913START domain
SuperFamilySSF559611.3E-33217453No hitNo description
CDDcd088751.94E-115220450No hitNo description
SMARTSM002341.2E-46225451IPR002913START domain
PfamPF018526.7E-48226451IPR002913START domain
SuperFamilySSF559616.0E-22472708No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0008289Molecular Functionlipid binding
GO:0043565Molecular Functionsequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 718 aa     Download sequence    Send to blast
MEYGSGGGGG GTGSGGGGDP HDAAERRKKR YHRHTANQIQ RLESIFKECP HPDEKTRLQL  60
SRDLGLAPRQ IKFWFQNRRT QMKAQHERAD NCALRAENDK IRCENIAIRE ALKNVICPSC  120
GGPPVTEDSY FDEQKLRIEN MQLKEELDKV SSIAAKYIGR PISQLPPVQP IHLSSLDLSM  180
SSFVGHGPNS LDLDLDLLPG SSSTIPGLAF ASLNLSDMDK SLMADIAGNA MDELIRLVQT  240
NEPLWMKSAI DGKDVLNFEN YDRIFPRANS HLKNHNVRIE ASRDSGVVIM NGLTLVDMFM  300
DANKWQEFFP TIVSKARTLE VISSGVMGSR MSTLQLMYEE LQVLSPLVPT RQLYFLRFCQ  360
QIEQSLWAIV DVSYDITQEN LYSSTSCKVH RLPSGCLIQD MPNGYSKVTW VEHVEVEEKG  420
IIHRLCRDLL HSGLAFGAER WIGTLQRVCE RYACLMVNSN PTHDLGGVIP SPEGKRSMMK  480
LAKRMVSNFC ASINPSNGHQ WNTISGLNEF EVRATLQKST DPGQPNGVII SAATTIWLPV  540
PPQNVFNFFR DERTRPQWDV LSNQNPVQEV AHIANGSHPG NCISVLRAYN TSQNMMLILQ  600
ESCIDSSGAL VVYSPVDVPA INIAMSGEDP TYIPLLPSGF TISPDGHQLD QEAASCSNSS  660
NASTIGGRSG GSLITVVFQI LVSSLPSAKM SPESVNTVNN LIGSTVHQIK AALNCSTS
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_019225984.10.0PREDICTED: homeobox-leucine zipper protein HDG11-like
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A314KSY20.0A0A314KSY2_NICAT; Homeobox-leucine zipper protein hdg11
STRINGXP_009786509.10.0(Nicotiana sylvestris)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
AsteridsOGEA24902351
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  3. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  4. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  5. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  6. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  7. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  8. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  9. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  10. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]