PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Solanales; Solanaceae; Nicotianoideae; Nicotianeae; Nicotiana

Family

E2F/DP

Protein Properties

Length: 497aa MW: 54540.1 Da PI: 4.61

Description

E2F/DP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Niben101Scf01372g01005.1	genome	BTI	-

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	E2F_TDP	78	8.8e-25	181	240	7	71
E2F_TDP 7 rlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71 +llt+kf++l++++e+g+++ln++a++L +v ++RRiYDi+NVLe+++liekk kn+i+wkg Niben101Scf01372g01005.1 181 GLLTKKFINLIKHAEDGMLDLNQAADTL---EV--QKRRIYDITNVLEGIGLIEKKLKNRIQWKG 240 69************************...99..**************************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SMART	SM01372	3.4E-27	175	240	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF46785	2.27E-15	180	238	IPR011991	Winged helix-turn-helix DNA-binding domain
Gene3D	G3DSA:1.10.10.10	8.0E-26	181	242	IPR011991	Winged helix-turn-helix DNA-binding domain
Pfam	PF02319	2.7E-22	181	240	IPR003316	E2F/DP family, winged-helix DNA-binding domain
SuperFamily	SSF144074	3.14E-32	254	357	No hit	No description
Pfam	PF16421	4.9E-32	256	355	IPR032198	E2F transcription factor, CC-MB domain
CDD	cd14660	2.55E-46	256	357	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0005667	Cellular Component	transcription factor complex
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 497 aa Download sequence Send to blast
MSFDTNMTGP DAPPTGVAAP PPAQSSSAAV NGGGRNQISQ PIKRYLPFAS MRPPFVSPED 60 YHRFGGVDSR IGSPTVQPDA IVVKSPALKR KGGMGYKAVE SSDWTANPGY SDVANSPLGT 120 PVSGKGGRAN GRSKATKSNK SGPPTPVSNV GEAWFSFSSY TCKLPLRQFI GYLMIFCPWI 180 GLLTKKFINL IKHAEDGMLD LNQAADTLEV QKRRIYDITN VLEGIGLIEK KLKNRIQWKG 240 VDASRPGEVD NDAAILKAET ESLSMEERRL DDRVRELQEK LRDMSEDEDD QKWLFVTEED 300 IKSLPCFQNE TLIAVKAPHG TTLEVPDPDE AVDYPQRRYR IILRSTMGPI DVYLVSQFEE 360 KFEEMNSVEP SMAIPVASSS GSKDNPAMER STLSNNVTEN EGQTQNVDQL SSDLGASQDY 420 SGGMMKVVPS DVDNDADYWL LSDAHVSITN MWEADPAVEW DGENLLHEFG ITDLGTPRAH 480 TPSAVTDVPT PMNVPPR

Sequence ? help Back to Top

Protein Sequence Length: 497 aa Download sequence Send to blast

MSFDTNMTGP DAPPTGVAAP PPAQSSSAAV NGGGRNQISQ PIKRYLPFAS MRPPFVSPED  60
YHRFGGVDSR IGSPTVQPDA IVVKSPALKR KGGMGYKAVE SSDWTANPGY SDVANSPLGT  120
PVSGKGGRAN GRSKATKSNK SGPPTPVSNV GEAWFSFSSY TCKLPLRQFI GYLMIFCPWI  180
GLLTKKFINL IKHAEDGMLD LNQAADTLEV QKRRIYDITN VLEGIGLIEK KLKNRIQWKG  240
VDASRPGEVD NDAAILKAET ESLSMEERRL DDRVRELQEK LRDMSEDEDD QKWLFVTEED  300
IKSLPCFQNE TLIAVKAPHG TTLEVPDPDE AVDYPQRRYR IILRSTMGPI DVYLVSQFEE  360
KFEEMNSVEP SMAIPVASSS GSKDNPAMER STLSNNVTEN EGQTQNVDQL SSDLGASQDY  420
SGGMMKVVPS DVDNDADYWL LSDAHVSITN MWEADPAVEW DGENLLHEFG ITDLGTPRAH  480
TPSAVTDVPT PMNVPPR

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
1cf7_A	4e-22	180	241	12	74	PROTEIN (TRANSCRIPTION FACTOR E2F-4)
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The binding of retinoblastoma-related proteins represses transactivation. Regulates gene expression both positively and negatively. Activates the expression of E2FB. Involved in the control of cell-cycle progression from G1 to S phase. Stimulates cell proliferation and delays differentiation. {ECO:0000269\|PubMed:11669580, ECO:0000269\|PubMed:11786543, ECO:0000269\|PubMed:11862494, ECO:0000269\|PubMed:11889041, ECO:0000269\|PubMed:11891240, ECO:0000269\|PubMed:12913157, ECO:0000269\|PubMed:15377755, ECO:0000269\|PubMed:16514015, ECO:0000269\|PubMed:19662336}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_009789426.1	0.0	PREDICTED: transcription factor E2FA isoform X1
Swissprot	Q9FNY0	1e-147	E2FA_ARATH; Transcription factor E2FA
TrEMBL	A0A1U7XIF6	0.0	A0A1U7XIF6_NICSY; transcription factor E2FA isoform X1
STRING	XP_009789426.1	0.0	(Nicotiana sylvestris)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA1077	24	84

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT2G36010.1	1e-144	E2F transcription factor 3

Publications ? help Back to Top
Magyar Z, et al. Arabidopsis E2FA stimulates proliferation and endocycle separately through RBR-bound and RBR-free complexes. EMBO J., 2012. 31(6): p. 1480-93 [PMID:22307083]