PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta

Family

C2H2

Protein Properties

Length: 522aa MW: 57845.7 Da PI: 6.7523

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Neem_5941_f_2	genome	NGD	View Nucleic Acid

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	21	8.7e-07	274	295	2	23
EETTTTEEESSHHHHHHHHHHT CS zf-C2H2 2 kCpdCgksFsrksnLkrHirtH 23 C++Cgk F+r nL+ H+r H Neem_5941_f_2 274 FCTICGKGFKRDANLRMHMRGH 295 6*******************98 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	2.25E-5	271	298	No hit	No description
SMART	SM00355	0.0026	273	295	IPR015880	Zinc finger, C2H2-like
PROSITE profile	PS50157	12.03	273	300	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	1.0E-5	274	324	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE pattern	PS00028	0	275	295	IPR007087	Zinc finger, C2H2
SMART	SM00355	56	322	355	IPR015880	Zinc finger, C2H2-like
SMART	SM00355	23	360	382	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0010044	Biological Process	response to aluminum ion
GO:0010447	Biological Process	response to acidic pH
GO:0005634	Cellular Component	nucleus
GO:0003676	Molecular Function	nucleic acid binding
GO:0003700	Molecular Function	transcription factor activity, sequence-specific DNA binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 522 aa Download sequence Send to blast
MDLKDKVCTD TWAKSSSSAN EISKVISSDN PSFPDFNAQQ HQQKWEDTSM LDYGIRIDPP 60 FQEFGQSPQT QSSLPCDPSN QIKFPVSLTE TLQTNKLQDW DPKVMLNNLS FLEQKIHQLQ 120 DLVHLIVGRR SQVLGRPDEL VAQQQQLITA DLTSIIVQLI STAGSLLPSV KHTLSATTSS 180 FGQFGQFGQF GGVPFGPGPG ISGGIPSHSS DVKKVSNQSN QIDAGNSGTQ QNHAVEEHEL 240 KDEEDADEGE NLPPGSYEIL QLEKEEILAP HTHFCTICGK GFKRDANLRM HMRGHGDEYK 300 TPAALAKPHK ESGSEPMLIK RYSCPYTGCK RNKDHKKFQP LKTILCVKNH YKRTHCDKSY 360 VCSRCNTKKF SVIADLKTHE KHCGKDKWLC SCGTTFSRKD KLFGHIALFQ GHTPAIPLDE 420 TIKGLAGPSD RREGNEATSK NGSINFNFAS NVRSGTGVQN DMDAKVNADD PANYFSPLNF 480 DTCNFDGFHE FPRPPFDDPE TSFSFLIPGS CNYIQKTGGE SS

Sequence ? help Back to Top

Protein Sequence Length: 522 aa Download sequence Send to blast

MDLKDKVCTD TWAKSSSSAN EISKVISSDN PSFPDFNAQQ HQQKWEDTSM LDYGIRIDPP  60
FQEFGQSPQT QSSLPCDPSN QIKFPVSLTE TLQTNKLQDW DPKVMLNNLS FLEQKIHQLQ  120
DLVHLIVGRR SQVLGRPDEL VAQQQQLITA DLTSIIVQLI STAGSLLPSV KHTLSATTSS  180
FGQFGQFGQF GGVPFGPGPG ISGGIPSHSS DVKKVSNQSN QIDAGNSGTQ QNHAVEEHEL  240
KDEEDADEGE NLPPGSYEIL QLEKEEILAP HTHFCTICGK GFKRDANLRM HMRGHGDEYK  300
TPAALAKPHK ESGSEPMLIK RYSCPYTGCK RNKDHKKFQP LKTILCVKNH YKRTHCDKSY  360
VCSRCNTKKF SVIADLKTHE KHCGKDKWLC SCGTTFSRKD KLFGHIALFQ GHTPAIPLDE  420
TIKGLAGPSD RREGNEATSK NGSINFNFAS NVRSGTGVQN DMDAKVNADD PANYFSPLNF  480
DTCNFDGFHE FPRPPFDDPE TSFSFLIPGS CNYIQKTGGE SS

Functional Description ? help Back to Top
Source	Description
UniProt	Probable transcription factor. Together with STOP2, plays a critical role in tolerance to major stress factors in acid soils such as proton H(+) and aluminum ion Al(3+). Required for the expression of genes in response to acidic stress (e.g. ALMT1 and MATE), and Al-activated citrate exudation. {ECO:0000269\|PubMed:17535918, ECO:0000269\|PubMed:18826429, ECO:0000269\|PubMed:19321711, ECO:0000269\|PubMed:23935008}.

Binding Motif ? help Back to Top
Motif ID	Method	Source	Motif file
MP00196	ampDAP	Transfer from AT1G34370	Download

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: By shock H(+) and Al(3+) treatments. {ECO:0000269\|PubMed:17535918}.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006473208.1	0.0	protein SENSITIVE TO PROTON RHIZOTOXICITY 1
Swissprot	Q9C8N5	0.0	STOP1_ARATH; Protein SENSITIVE TO PROTON RHIZOTOXICITY 1
TrEMBL	A0A067H8K8	0.0	A0A067H8K8_CITSI; Uncharacterized protein
TrEMBL	A0A2H5NHP3	0.0	A0A2H5NHP3_CITUN; Uncharacterized protein
STRING	XP_006473208.1	0.0	(Citrus sinensis)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM6977	26	44

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G34370.2	0.0	C2H2 family protein

Publications ? help Back to Top
Kobayashi Y, et al. Molecular and physiological analysis of Al³⁺ and H⁺ rhizotoxicities at moderately acidic conditions. Plant Physiol., 2013. 163(1): p. 180-92 [PMID:23839867] Yokosho K,Yamaji N,Ma JF Global transcriptome analysis of Al-induced genes in an Al-accumulating species, common buckwheat (Fagopyrum esculentum Moench). Plant Cell Physiol., 2014. 55(12): p. 2077-91 [PMID:25273892] Geng X, et al. LEUNIG_HOMOLOG transcriptional co-repressor mediates aluminium sensitivity through PECTIN METHYLESTERASE46-modulated root cell wall pectin methylesterification in Arabidopsis. Plant J., 2017. 90(3): p. 491-504 [PMID:28181322] Balzergue C, et al. Low phosphate activates STOP1-ALMT1 to rapidly inhibit root cell elongation. Nat Commun, 2017. 8: p. 15300 [PMID:28504266] Pelagio-Flores R,Esparza-Reynoso S,Garnica-Vergara A,López-Bucio J,Herrera-Estrella A Trichoderma-Induced Acidification Is an Early Trigger for Changes in Arabidopsis Root Growth and Determines Fungal Phytostimulation. Front Plant Sci, 2017. 8: p. 822 [PMID:28567051] Jiang F, et al. Identification and characterization of suppressor mutants of stop1. BMC Plant Biol., 2017. 17(1): p. 128 [PMID:28738784] Daspute AA, et al. Transcriptional Regulation of Aluminum-Tolerance Genes in Higher Plants: Clarifying the Underlying Molecular Mechanisms. Front Plant Sci, 2017. 8: p. 1358 [PMID:28848571] Sharma A,Wai CM,Ming R,Yu Q Diurnal Cycling Transcription Factors of Pineapple Revealed by Genome-Wide Annotation and Global Transcriptomic Analysis. Genome Biol Evol, 2017. 9(9): p. 2170-2190 [PMID:28922793] Zhang Y, et al. The Cell Cycle Checkpoint Regulator ATR Is Required for Internal Aluminum Toxicity-Mediated Root Growth Inhibition in Arabidopsis. Front Plant Sci, 2018. 9: p. 118 [PMID:29491872]