PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Neem_4779_f_10

Organism

Azadirachta indica

Taxonomic ID

124943

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta

Family

bHLH

Protein Properties

Length: 2553aa MW: 288924 Da PI: 6.6739

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Neem_4779_f_10	genome	NGD	View Nucleic Acid

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	18.7	3.2e-06	2435	2473	12	55
HHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS HLH 12 RRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 RR+++ ++ ++L++l+P + kK++ a++Le+A +Y++ Lq Neem_4779_f_10 2435 RREKMSDKTQRLQKLMPFD-----KKMDIATMLEEAFKYVQFLQ 2473 9***************9.....9****************9 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.80.10.10	1.3E-10	1177	1326	IPR032675	Leucine-rich repeat domain, L domain-like
Pfam	PF00856	3.3E-12	1774	1939	IPR001214	SET domain
PROSITE profile	PS50280	11.782	1800	1939	IPR001214	SET domain
SMART	SM00317	3.0E-24	1805	1945	IPR001214	SET domain
Gene3D	G3DSA:2.170.270.10	3.4E-35	1814	1963	No hit	No description
SuperFamily	SSF82199	7.06E-28	1814	1962	No hit	No description
PROSITE profile	PS50888	11.407	2423	2472	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SMART	SM00353	4.8E-5	2430	2478	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	1.0E-7	2434	2480	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	5.76E-8	2435	2482	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
CDD	cd00083	2.69E-6	2435	2477	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0010228	Biological Process	vegetative to reproductive phase transition of meristem
GO:0048440	Biological Process	carpel development
GO:0048443	Biological Process	stamen development
GO:0042800	Molecular Function	histone methyltransferase activity (H3-K4 specific)
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 2553 aa Download sequence Send to blast
MEKKEVQKST CTTTTSNNSN NDNTKGGENG GAGDGVTVDK DKLRSDEVEE GELGTLKWEN 60 GEFVQPEKSH SHLQPQSQVQ SQPRSEPQLQ PESQPQLRPQ LQLESKRSEI EKGEIVFSSL 120 KWQRGEGEKG EYGLLKGNKD DIEKGEFIPD RWHKGDGVKD DYGYSKSRRY EPKLERTPPS 180 AKYSGEDFFR RKEFDRSGSQ HSKSSSRWES GHERNVRISS KIVDDESLFK GEYSNGKNHG 240 RDYSSGNRLK RHGTDSDSAE RKYYGDYGDF AGSKSRRLSD DYNTRSVHSD HYSRHSVERF 300 YRNSSSSRLS SSDKYSSRHH ESSVSSRVVY DRHGRSPGLS ERSPRDRSRY YDHRDRSPGR 360 RDRSPYTRDR SPYTLDRSPY SRDRSPYSRD RSPYSRDKSP YDRSRHYDHR NRSPMSAERS 420 PQERARFHDR RDRTPNYLEQ SPFDRNRPNN YREASRKSGA SEKRNAKNDS KCQEDKLGQK 480 DGNAGCSHSS SKESQDKSSV QDLNVSEEKN TKSDSHKEEQ CQSSSVNCRE STHVDEPPPE 540 ELLSMEEDMD ICDTPPHVTV MTDSSVGKWF YLDHFGMECG PSKLSALKAL VEGGVLASDH 600 FIKHLDSDRW VTVENAVSPV ATVNFPSIAS DSVTQLVSPP EAPGNLLADT GDTVQSGGEE 660 LQVTLRQSRC CPDDSAAEPE SLEDLHINGR VGALLKGFTV IPGKEIEILG EILQATFEHV 720 EWQNNGGLTW HGARVGEQEQ DDQKVDELSK YSDIKIKDAT ELRVGEQDHG LASLDSDDWF 780 SGRWSCKGGD WKRNDEAPQD RCSRRKLVLN DGFPLCQMPK SGYEDPRWHQ KDDLYYPSHS 840 RRLDLPPWAF SCPDERNDGS GSSRSTQSKL AVVRGMKGTM LPVVRINACV VNDQGSFVLE 900 PRSKVRAKEK HSSRSARSYS SANDTRRSSA ESDSHSKTIN GHELPGSWKS HASINTPKDR 960 LCTVDDLQLH LGDWYYLDGA GHERGPSSFS ELQVLVDQGA IPKHTSVFRK FDKVWVPVMS 1020 AAEASATTVR NQQENTDSSG PPLAKSQDAA FAERKSNVNS SSFHSMHPQF IGYTRGRLHE 1080 LVMKSYKSRE FAAAINEVLD PWINAKQPKK ETEHVYRKSE VDARAGKRAR LLVDESEGDD 1140 ETEEDLQTIQ DESTFEDLCG DASFHGEESA DSGTESGSWG LLDGHTLARV FHFLRSDMKS 1200 LTIASSTCRH WRAAVSFYKG ISRQVDLSSV GPNCTDSVIW NILNAYDKGK LHSMVLAGCT 1260 NITSGMLEEI LHLFPHLSSV DIRGCGQLGE LAHKFPNMNW VQSQSSRATK FSNDSHSKIR 1320 SLKQITEKAS SVSKTKGLGG NVDDFGDLKD YFESVDKRDS ANQLFRRSLY QRSKVFDARK 1380 SSSIVSRDAR MRRWAIKKSE NGYKRMEEFL ASSLKEIMRK NTFDFFVPKV AEIEERMKNG 1440 YYISHGLNSV KDDISRMCRD AIKTKNRGGA VDMNRIITLF IQLATRLEQG AKSSYYEREE 1500 MMRCWKDESP AGIYSAASKY KKKLGKMVSE RKYRSNGTSF ANGDFDYVEY ASDREIRKRL 1560 SKLNRKSLDS GSETSDDLDR SSDDGKSDSE STVSDTDSDL DFRSDGRARE SRGDGEFSAE 1620 EGLDFMSDER EWGARMTKAS LVPPVTRKYE VIDQYVIVAD EEDVKRKMTV SLPEDYAEKL 1680 NAQKNGSEEL DMELPEVKDY KPRKQLGDQV IEQEVYGIDP YTHNLLLDSM PEELDWTLQD 1740 KHSFIEDVLL RTLNKQVRHF TGTGNTPMIY PLQPIVEEIE KDAEEACDVR TMKICQGVLK 1800 AIDSRPDDKY VAYRKGLGVV CNKEHGFGGD DFVVEFLGEV YPVWKWFEKQ DGIRSLQKNN 1860 EDPAPEFYNI YLERPKGDAD GYDLVVVDAM HKANYASRIC HSCRPNCEAK VTAVDGQYQI 1920 GIYTVREIQY GEEITFDYNS VTESKEEYEA SVCLCGSQVC RGSYLNLTGE GAFQKVLKEC 1980 HGFLDRHQLM LEACELNSVS EEDYFDLGRA GLGSCLLGGL PNWVVAYSAR LVRFINLERT 2040 KLPDEILRHN LEEKRKYFSD ICLEVEQSDA EVQAEGVYNQ RLQNLAVTLD KAPPPLEKLS 2100 PEATVSFLWN GEGSLVEELL QCMAPHVEED MLNDLKSKIH AHNPSGSDDI QGELRKSLLW 2160 LRDEVRNLPC TYKCRHDAAA DLIHIYAYTK CFFRVREYKA FTSPPVYISP LDLGPKYADK 2220 LGAGLQEYRK TYGENYCLGQ LIFWHVQTNA DPDCTLARMS RGSLSLPDVS SFYAKVQKPS 2280 RHRVYGPKAV RFMLSRMEKL PQRPWPKDRI WSFKSSPKIF GSPMLDAIMG GSSLDREMFA 2340 AAPVFDVGVG NHSKTSACAR ACAGFFILLY RPSPLHNFQP PSISLSLDHS SHTHPHHHSK 2400 LTVVTDSSSS STRKRRRSES VVHAASPPAP ASVHRREKMS DKTQRLQKLM PFDKKMDIAT 2460 MLEEAFKYVQ FLQSQIRALS SMPLQSSFVV QNDICDWGGR FGCLGMLNRQ QLLQVFVNSP 2520 VAQSMLYSQG SCVFSLEQLL LMNQLSPANL SPQ

Sequence ? help Back to Top

Protein Sequence Length: 2553 aa Download sequence Send to blast

MEKKEVQKST CTTTTSNNSN NDNTKGGENG GAGDGVTVDK DKLRSDEVEE GELGTLKWEN  60
GEFVQPEKSH SHLQPQSQVQ SQPRSEPQLQ PESQPQLRPQ LQLESKRSEI EKGEIVFSSL  120
KWQRGEGEKG EYGLLKGNKD DIEKGEFIPD RWHKGDGVKD DYGYSKSRRY EPKLERTPPS  180
AKYSGEDFFR RKEFDRSGSQ HSKSSSRWES GHERNVRISS KIVDDESLFK GEYSNGKNHG  240
RDYSSGNRLK RHGTDSDSAE RKYYGDYGDF AGSKSRRLSD DYNTRSVHSD HYSRHSVERF  300
YRNSSSSRLS SSDKYSSRHH ESSVSSRVVY DRHGRSPGLS ERSPRDRSRY YDHRDRSPGR  360
RDRSPYTRDR SPYTLDRSPY SRDRSPYSRD RSPYSRDKSP YDRSRHYDHR NRSPMSAERS  420
PQERARFHDR RDRTPNYLEQ SPFDRNRPNN YREASRKSGA SEKRNAKNDS KCQEDKLGQK  480
DGNAGCSHSS SKESQDKSSV QDLNVSEEKN TKSDSHKEEQ CQSSSVNCRE STHVDEPPPE  540
ELLSMEEDMD ICDTPPHVTV MTDSSVGKWF YLDHFGMECG PSKLSALKAL VEGGVLASDH  600
FIKHLDSDRW VTVENAVSPV ATVNFPSIAS DSVTQLVSPP EAPGNLLADT GDTVQSGGEE  660
LQVTLRQSRC CPDDSAAEPE SLEDLHINGR VGALLKGFTV IPGKEIEILG EILQATFEHV  720
EWQNNGGLTW HGARVGEQEQ DDQKVDELSK YSDIKIKDAT ELRVGEQDHG LASLDSDDWF  780
SGRWSCKGGD WKRNDEAPQD RCSRRKLVLN DGFPLCQMPK SGYEDPRWHQ KDDLYYPSHS  840
RRLDLPPWAF SCPDERNDGS GSSRSTQSKL AVVRGMKGTM LPVVRINACV VNDQGSFVLE  900
PRSKVRAKEK HSSRSARSYS SANDTRRSSA ESDSHSKTIN GHELPGSWKS HASINTPKDR  960
LCTVDDLQLH LGDWYYLDGA GHERGPSSFS ELQVLVDQGA IPKHTSVFRK FDKVWVPVMS  1020
AAEASATTVR NQQENTDSSG PPLAKSQDAA FAERKSNVNS SSFHSMHPQF IGYTRGRLHE  1080
LVMKSYKSRE FAAAINEVLD PWINAKQPKK ETEHVYRKSE VDARAGKRAR LLVDESEGDD  1140
ETEEDLQTIQ DESTFEDLCG DASFHGEESA DSGTESGSWG LLDGHTLARV FHFLRSDMKS  1200
LTIASSTCRH WRAAVSFYKG ISRQVDLSSV GPNCTDSVIW NILNAYDKGK LHSMVLAGCT  1260
NITSGMLEEI LHLFPHLSSV DIRGCGQLGE LAHKFPNMNW VQSQSSRATK FSNDSHSKIR  1320
SLKQITEKAS SVSKTKGLGG NVDDFGDLKD YFESVDKRDS ANQLFRRSLY QRSKVFDARK  1380
SSSIVSRDAR MRRWAIKKSE NGYKRMEEFL ASSLKEIMRK NTFDFFVPKV AEIEERMKNG  1440
YYISHGLNSV KDDISRMCRD AIKTKNRGGA VDMNRIITLF IQLATRLEQG AKSSYYEREE  1500
MMRCWKDESP AGIYSAASKY KKKLGKMVSE RKYRSNGTSF ANGDFDYVEY ASDREIRKRL  1560
SKLNRKSLDS GSETSDDLDR SSDDGKSDSE STVSDTDSDL DFRSDGRARE SRGDGEFSAE  1620
EGLDFMSDER EWGARMTKAS LVPPVTRKYE VIDQYVIVAD EEDVKRKMTV SLPEDYAEKL  1680
NAQKNGSEEL DMELPEVKDY KPRKQLGDQV IEQEVYGIDP YTHNLLLDSM PEELDWTLQD  1740
KHSFIEDVLL RTLNKQVRHF TGTGNTPMIY PLQPIVEEIE KDAEEACDVR TMKICQGVLK  1800
AIDSRPDDKY VAYRKGLGVV CNKEHGFGGD DFVVEFLGEV YPVWKWFEKQ DGIRSLQKNN  1860
EDPAPEFYNI YLERPKGDAD GYDLVVVDAM HKANYASRIC HSCRPNCEAK VTAVDGQYQI  1920
GIYTVREIQY GEEITFDYNS VTESKEEYEA SVCLCGSQVC RGSYLNLTGE GAFQKVLKEC  1980
HGFLDRHQLM LEACELNSVS EEDYFDLGRA GLGSCLLGGL PNWVVAYSAR LVRFINLERT  2040
KLPDEILRHN LEEKRKYFSD ICLEVEQSDA EVQAEGVYNQ RLQNLAVTLD KAPPPLEKLS  2100
PEATVSFLWN GEGSLVEELL QCMAPHVEED MLNDLKSKIH AHNPSGSDDI QGELRKSLLW  2160
LRDEVRNLPC TYKCRHDAAA DLIHIYAYTK CFFRVREYKA FTSPPVYISP LDLGPKYADK  2220
LGAGLQEYRK TYGENYCLGQ LIFWHVQTNA DPDCTLARMS RGSLSLPDVS SFYAKVQKPS  2280
RHRVYGPKAV RFMLSRMEKL PQRPWPKDRI WSFKSSPKIF GSPMLDAIMG GSSLDREMFA  2340
AAPVFDVGVG NHSKTSACAR ACAGFFILLY RPSPLHNFQP PSISLSLDHS SHTHPHHHSK  2400
LTVVTDSSSS STRKRRRSES VVHAASPPAP ASVHRREKMS DKTQRLQKLM PFDKKMDIAT  2460
MLEEAFKYVQ FLQSQIRALS SMPLQSSFVV QNDICDWGGR FGCLGMLNRQ QLLQVFVNSP  2520
VAQSMLYSQG SCVFSLEQLL LMNQLSPANL SPQ

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
4ynp_A	8e-13	1808	1962	81	215	Histone-lysine N-methyltransferase ASH1L
4ynp_B	8e-13	1808	1962	81	215	Histone-lysine N-methyltransferase ASH1L
Search in ModeBase

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	2412	2416	RKRRR
2	2412	2417	RKRRRS

Functional Description ? help Back to Top
Source	Description
UniProt	Histone methyltransferase specifically required for trimethylation of 'Lys-4' of histone H3 (H3K4me3) and is crucial for both sporophyte and gametophyte development (PubMed:21037105, PubMed:20937886).

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AC208095	2e-37	AC208095.1 Populus trichocarpa clone JGIACSB09-L15, complete sequence.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006447454.1	0.0	histone-lysine N-methyltransferase ATXR3
Refseq	XP_006469738.1	0.0	histone-lysine N-methyltransferase ATXR3
Swissprot	O23372	0.0	ATXR3_ARATH; Histone-lysine N-methyltransferase ATXR3
TrEMBL	A0A067DAN1	0.0	A0A067DAN1_CITSI; Uncharacterized protein
STRING	XP_006469738.1	0.0	(Citrus sinensis)
STRING	XP_006447454.1	0.0	(Citrus clementina)

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT3G22100.1	8e-25	bHLH family protein

Publications ? help Back to Top
Baumbusch LO, et al. The Arabidopsis thaliana genome contains at least 29 active genes encoding SET domain proteins that can be assigned to four evolutionarily conserved classes. Nucleic Acids Res., 2001. 29(21): p. 4319-33 [PMID:11691919] Springer NM, et al. Comparative analysis of SET domain proteins in maize and Arabidopsis reveals multiple duplications preceding the divergence of monocots and dicots. Plant Physiol., 2003. 132(2): p. 907-25 [PMID:12805620] Staal J,Kaliff M,Bohman S,Dixelius C Transgressive segregation reveals two Arabidopsis TIR-NB-LRR resistance genes effective against Leptosphaeria maculans, causal agent of blackleg disease. Plant J., 2006. 46(2): p. 218-30 [PMID:16623885] Guo L,Yu Y,Law JA,Zhang X SET DOMAIN GROUP2 is the major histone H3 lysine [corrected] 4 trimethyltransferase in Arabidopsis. Proc. Natl. Acad. Sci. U.S.A., 2010. 107(43): p. 18557-62 [PMID:20937886] Malapeira J,Khaitova LC,Mas P Ordered changes in histone modifications at the core of the Arabidopsis circadian clock. Proc. Natl. Acad. Sci. U.S.A., 2012. 109(52): p. 21540-5 [PMID:23236129] Malapeira J,Mas P A chromatin-dependent mechanism regulates gene expression at the core of the Arabidopsis circadian clock. Plant Signal Behav, 2013. 8(5): p. e24079 [PMID:23470726] Yao X,Feng H,Yu Y,Dong A,Shen WH SDG2-mediated H3K4 methylation is required for proper Arabidopsis root growth and development. PLoS ONE, 2013. 8(2): p. e56537 [PMID:23483879] Zhao F, et al. Phosphorylation of SPOROCYTELESS/NOZZLE by the MPK3/6 Kinase Is Required for Anther Development. Plant Physiol., 2017. 173(4): p. 2265-2277 [PMID:28209842] Pinon V,Yao X,Dong A,Shen WH SDG2-Mediated H3K4me3 Is Crucial for Chromatin Condensation and Mitotic Division during Male Gametogenesis in Arabidopsis. Plant Physiol., 2017. 174(2): p. 1205-1215 [PMID:28455402] Chen LQ, et al. ATX3, ATX4, and ATX5 Encode Putative H3K4 Methyltransferases and Are Critical for Plant Development. Plant Physiol., 2017. 174(3): p. 1795-1806 [PMID:28550207]