PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Neem_2882_f_1
Organism
Azadirachta indica
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta
Family C2H2
Protein Properties Length: 397aa    MW: 45340.6 Da    PI: 7.7706
Description C2H2 family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Neem_2882_f_1genomeNGDView Nucleic Acid
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1zf-C2H212.20.0005579101323
                    ET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   3 Cp..dCgksFsrksnLkrHirtH 23 
                    C+   Cgk+F +   L++H   H
  Neem_2882_f_1  79 CSyeGCGKTFIDAGALRKHSHIH 101
                    77779**************7766 PP
2zf-C2H215.83.9e-05106130123
                    EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                    y+C+  +Cgk F ++s LkrH   H
  Neem_2882_f_1 106 YVCHyeNCGKKFLDSSKLKRHFLIH 130
                    9********************8877 PP
3zf-C2H220.61.2e-06136160123
                    EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                    + Cp   Cgk Fs   nL++H++tH
  Neem_2882_f_1 136 FICPheGCGKAFSLDFNLRSHMKTH 160
                    78**********************9 PP
4zf-C2H217.71e-05166190123
                    EEET..TTTEEESSHHHHHHHHHHT CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirtH 23 
                    + Cp  dCgk++ + + Lk+Hi +H
  Neem_2882_f_1 166 HICPypDCGKRYAHEYKLKNHIASH 190
                    679999*****************96 PP
5zf-C2H212.90.00034229254123
                    EEET..TTTEEESSHHHHHHHHHH.T CS
        zf-C2H2   1 ykCp..dCgksFsrksnLkrHirt.H 23 
                    y Cp   C k + + + Lk H+++ H
  Neem_2882_f_1 229 YACPydGCEKAYIHEYKLKLHLKReH 254
                    89*********************999 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.160.601.0E-1372103IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.003277101IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015710.78377106IPR007087Zinc finger, C2H2
PROSITE patternPS00028079101IPR007087Zinc finger, C2H2
SuperFamilySSF576674.17E-880130No hitNo description
Gene3DG3DSA:3.30.160.606.8E-14104126IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.011106130IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015714.17106135IPR007087Zinc finger, C2H2
PROSITE patternPS000280108130IPR007087Zinc finger, C2H2
SuperFamilySSF576676.15E-14117169No hitNo description
Gene3DG3DSA:3.30.160.606.7E-20127160IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003553.9E-4136160IPR015880Zinc finger, C2H2-like
PROSITE profilePS5015712.591136165IPR007087Zinc finger, C2H2
PROSITE patternPS000280138160IPR007087Zinc finger, C2H2
Gene3DG3DSA:3.30.160.603.7E-9161192IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.0028166190IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.473166195IPR007087Zinc finger, C2H2
PROSITE patternPS000280168191IPR007087Zinc finger, C2H2
SuperFamilySSF576671.74E-5224252No hitNo description
Gene3DG3DSA:3.30.160.609.5E-9225251IPR013087Zinc finger C2H2-type/integrase DNA-binding domain
SMARTSM003550.01229254IPR015880Zinc finger, C2H2-like
PROSITE profilePS501579.702229259IPR007087Zinc finger, C2H2
PROSITE patternPS000280231254IPR007087Zinc finger, C2H2
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0045892Biological Processnegative regulation of transcription, DNA-templated
GO:0045893Biological Processpositive regulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0043565Molecular Functionsequence-specific DNA binding
GO:0046872Molecular Functionmetal ion binding
Sequence ? help Back to Top
Protein Sequence    Length: 397 aa     Download sequence    Send to blast
METQFTHSYF DRRPIFKSKT PAVKWFKEWV PQDVVATGGR CQLFRWVNEN TLKALKEKAK  60
EPEAPEPEPE PTTEVLFLCS YEGCGKTFID AGALRKHSHI HGERQYVCHY ENCGKKFLDS  120
SKLKRHFLIH TGERDFICPH EGCGKAFSLD FNLRSHMKTH SQENYHICPY PDCGKRYAHE  180
YKLKNHIASH HEKNAAVEVP RYAAPPERIQ KTPKASAGAY GSASSDRPYA CPYDGCEKAY  240
IHEYKLKLHL KREHPGHTSD ENAENAAPNA DNEMDEGSDQ DAYTGKRVNG KSQKQSRPKP  300
SMKMPPAKVA QRKGSSPSPA TLNVVRKPWP PKEEIYEEED SEETEEDRDN VEDGYRYGQN  360
NDDDDEARKI VTMLKTGTGT GKITTTMTRR QNMKTET
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ubd_C3e-35791908117PROTEIN (YY1 ZINC FINGER DOMAIN)
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtDual-function transcription factor with both repression and activation activities. Binds to 5'-CCATATT-3' motif in target gene promoters (e.g. ABR1) (PubMed:26961720). Binds also to G-rich DNA motif 5'-GGGGGCAGTGG-3' (PubMed:22508367). Regulates the expression of genes involved in diverse cellular pathways, including glucose metabolism, photosynthesis, phototropism and stress response (e.g. salt, drought and osmotic stress) (PubMed:22508367, PubMed:26961720). Regulates plant immunity, especially during necrotrophic fungal infection (e.g. B.cinerea) (PubMed:24451981). Binds to ABR1 promoter and promotes its expression, thus negatively regulating the abscisic acid (ABA) signaling pathway. Represses ABA- and salt-responsive genes expression (PubMed:26961720). {ECO:0000269|PubMed:22508367, ECO:0000269|PubMed:24451981, ECO:0000269|PubMed:26961720}.
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced by abscisic acid (ABA) in an ABI1- and ABI4-dependent manner. Stimulated by stress conditions including high salt, osmotic stress (e.g. mannitol) and dehydration. May be induced by ABI4 but repressed by ABR1. Repressed by darkness but induced by light. {ECO:0000269|PubMed:26961720}.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_024949722.10.0zinc finger transcription factor YY1-like
SwissprotQ2V3L31e-160YY1_ARATH; Zinc finger transcription factor YY1
TrEMBLA0A1Q3AZP20.0A0A1Q3AZP2_CEPFO; Zf-H2C2_2 domain-containing protein/zf-C2H2_4 domain-containing protein
STRINGXP_006494357.10.0(Citrus sinensis)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
MalvidsOGEM58592846
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G06634.11e-142C2H2 family protein
Publications ? help Back to Top
  1. Kumekawa N,Hosouchi T,Tsuruoka H,Kotani H
    The size and sequence organization of the centromeric region of Arabidopsis thaliana chromosome 4.
    DNA Res., 2001. 8(6): p. 285-90
    [PMID:11853315]
  2. Li T,Wu XY,Li H,Song JH,Liu JY
    A Dual-Function Transcription Factor, AtYY1, Is a Novel Negative Regulator of the Arabidopsis ABA Response Network.
    Mol Plant, 2016. 9(5): p. 650-661
    [PMID:26961720]
  3. Wu XY,Li T
    A Casein Kinase II Phosphorylation Site in AtYY1 Affects Its Activity, Stability, and Function in the ABA Response.
    Front Plant Sci, 2017. 8: p. 323
    [PMID:28348572]