PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

PlantRegMap/PlantTFDB v5.0

Plant Transcription Factor Database

Transcription Factor Information

Basic Information | Signature Domain | Sequence |

Basic Information? help Back to Top

TF ID

Neem_16119_f_2

Organism

Azadirachta indica

Taxonomic ID

124943

Taxonomic Lineage

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Sapindales; Meliaceae; Azadirachta

Family

bHLH

Protein Properties

Length: 439aa MW: 49010.4 Da PI: 5.5385

Description

bHLH family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Neem_16119_f_2	genome	NGD	View Nucleic Acid

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	HLH	11.3	0.00065	277	329	5	54
HHHHHHHHHHHHHHH......HHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHH CS HLH 5 hnerErrRRdriNsa......feeLrellPkaskapskKlsKaeiLekAveYIksL 54 + rE+ RRdr+N++ f eL ++l + + +K++Ka L A + + +L Neem_16119_f_2 277 KACREKMRRDRLNDRhalnllFLELASILDPG---RPPKMDKAVLLADAARMVTQL 329 6789********99755555577888888776...789999999999999988887 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:3.40.30.10	1.1E-21	4	135	IPR012336	Thioredoxin-like fold
SuperFamily	SSF52833	1.36E-22	9	79	IPR012336	Thioredoxin-like fold
Pfam	PF00085	5.1E-8	19	77	IPR013766	Thioredoxin domain
CDD	cd02947	1.17E-19	29	134	No hit	No description
SuperFamily	SSF52833	1.36E-22	110	136	IPR012336	Thioredoxin-like fold
CDD	cd00083	2.71E-5	276	334	No hit	No description
PROSITE profile	PS50888	8.55	278	329	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
SuperFamily	SSF47459	1.57E-7	279	353	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Gene3D	G3DSA:4.10.280.10	1.4E-7	279	351	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0045454	Biological Process	cell redox homeostasis
GO:0046983	Molecular Function	protein dimerization activity

Sequence ? help Back to Top
Protein Sequence Length: 439 aa Download sequence Send to blast
MEVQGQEQQN KSRVVKVDSV ESWELFVSQA NNQGCPIVVH FTASWCMPSV VMNPFFEELA 60 SAYPDVLFLS VDVDDVKLMD DFVSSVHYNH LIKRACKLMP ATCPSKDVAS KMEVKAMPTF 120 VLMREGAVVD KFMGLLILEL NTVLKNSNGH VMYKWNCQFG ELCVRYPIGM KVVTTNFITT 180 LLFPTADNWP ENKTYVVDMS SPENPNWIFD YGLLEDIGVP GGELLSLDPP EVLWSSSATN 240 PPLSTEFDES FGNLDTPKEI GSRKRVRSGS CSASGSKACR EKMRRDRLND RHALNLLFLE 300 LASILDPGRP PKMDKAVLLA DAARMVTQLR DEAQKLKDSN ENLLVKINEL KCEKNELRDE 360 KSRLKTEKEN LDRQVKALSS QPAFLPQASP IPAPFPAPSQ VVGGKLVPFV GYPGVSMWQF 420 MPPTAVDTSQ DHVLRPPVA

Sequence ? help Back to Top

Protein Sequence Length: 439 aa Download sequence Send to blast

MEVQGQEQQN KSRVVKVDSV ESWELFVSQA NNQGCPIVVH FTASWCMPSV VMNPFFEELA  60
SAYPDVLFLS VDVDDVKLMD DFVSSVHYNH LIKRACKLMP ATCPSKDVAS KMEVKAMPTF  120
VLMREGAVVD KFMGLLILEL NTVLKNSNGH VMYKWNCQFG ELCVRYPIGM KVVTTNFITT  180
LLFPTADNWP ENKTYVVDMS SPENPNWIFD YGLLEDIGVP GGELLSLDPP EVLWSSSATN  240
PPLSTEFDES FGNLDTPKEI GSRKRVRSGS CSASGSKACR EKMRRDRLND RHALNLLFLE  300
LASILDPGRP PKMDKAVLLA DAARMVTQLR DEAQKLKDSN ENLLVKINEL KCEKNELRDE  360
KSRLKTEKEN LDRQVKALSS QPAFLPQASP IPAPFPAPSQ VVGGKLVPFV GYPGVSMWQF  420
MPPTAVDTSQ DHVLRPPVA

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
2iwt_A	2e-17	13	142	16	116	THIOREDOXIN H ISOFORM 2
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor. Plays a role in resistance to amide-linked indole-3-acetic acid (IAA) conjugates such as IAA-Leu and IAA-Phe. May regulate gene expression in response to metal homeostasis changes. {ECO:0000269\|PubMed:17028341}.

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	AM462697	6e-36	AM462697.1 Vitis vinifera, whole genome shotgun sequence, contig VV78X186172.18, clone ENTAV 115.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_006449136.1	1e-134	transcription factor ILR3
Swissprot	Q9FH37	1e-78	ILR3_ARATH; Transcription factor ILR3
TrEMBL	A0A2P5C4F5	1e-134	A0A2P5C4F5_TREOI; Basic helix-loop-helix transcription factor
STRING	XP_006449136.1	1e-133	(Citrus clementina)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Malvids	OGEM1437	28	90

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT5G54680.1	6e-69	bHLH family protein

Publications ? help Back to Top
Li X,Zhang H,Ai Q,Liang G,Yu D Two bHLH Transcription Factors, bHLH34 and bHLH104, Regulate Iron Homeostasis in Arabidopsis thaliana. Plant Physiol., 2016. 170(4): p. 2478-93 [PMID:26921305] Aparicio F,Pallás V The coat protein of Alfalfa mosaic virus interacts and interferes with the transcriptional activity of the bHLH transcription factor ILR3 promoting salicylic acid-dependent defence signalling response. Mol. Plant Pathol., 2017. 18(2): p. 173-186 [PMID:26929142] Liang G,Zhang H,Li X,Ai Q,Yu D bHLH transcription factor bHLH115 regulates iron homeostasis in Arabidopsis thaliana. J. Exp. Bot., 2017. 68(7): p. 1743-1755 [PMID:28369511] Ezer D, et al. The G-Box Transcriptional Regulatory Code in Arabidopsis. Plant Physiol., 2017. 175(2): p. 628-640 [PMID:28864470] Li B, et al. Network-Guided Discovery of Extensive Epistasis between Transcription Factors Involved in Aliphatic Glucosinolate Biosynthesis. Plant Cell, 2018. 30(1): p. 178-195 [PMID:29317470] Min JH, et al. Arabidopsis Basic Helix-Loop-Helix 34 (bHLH34) Is Involved in Glucose Signaling through Binding to a GAGA Cis-Element. Front Plant Sci, 2017. 8: p. 2100 [PMID:29321786] Samira R, et al. The bHLH transcription factor ILR3 modulates multiple stress responses in Arabidopsis. Plant Mol. Biol., 2018. 97(4-5): p. 297-309 [PMID:29882068]