PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; asterids; lamiids; Lamiales; Phrymaceae; Erythranthe

Family

HD-ZIP

Protein Properties

Length: 743aa MW: 83306 Da PI: 6.5983

Description

HD-ZIP family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Migut.I00940.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	Homeobox	65.9	5.6e-21	83	138	1	56
TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS Homeobox 1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56 r+k +++t+eq++e+e+lF+++++p++++r +L+k+lgL rqVk+WFqNrR++ k Migut.I00940.1.p 83 RKKYHRHTPEQITEMEALFKESPHPDENQRLQLSKQLGLHPRQVKFWFQNRRTQIK 138 7999************************************************9877 PP
2	START	183.1	1.5e-57	262	481	5	206
HHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS........SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEEE CS START 5 eaaqelvkkalaeepgWvkss....esengdevlqkfeeskv.......dsgealrasgvvdmvlallveellddkeqWdetla....kaetl 82 +a++el+k+a+ +ep+Wv s+ e++n+de++++f ++ +s+ea+++s++ + +l lv++++d + +W+e ++ +a+t+ Migut.I00940.1.p 262 SALNELIKMATHREPLWVPSYetgrEILNYDEYTKQFGNENYynkmqpnKSIEASKDSAIIFVDLLWLVRSFMDAN-RWQELFPclisSASTV 353 6899*******************************76666******************************.************ PP EEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE CS START 83 evissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwve 168 +vi++g ga++lm+ae q+l+p+v+ R+ +f R++++ + +w+ivdvS+d+++ ++s+ +++++pSg++ie+ksngh+kvtwve Migut.I00940.1.p 354 DVICNGegengdGAVHLMFAEIQMLTPMVAtREMYFFRHCKKVSTYQWAIVDVSIDEDNI---DASSQKCRKRPSGCIIEDKSNGHCKVTWVE 443 ****************************************************9988...56899999****************** PP -EE--SSXXHHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS START 169 hvdlkgrlphwllrslvksglaegaktwvatlqrqcek 206 h+++++ +h+l+rs+v++gla+ga++w tlq+qce+ Migut.I00940.1.p 444 HIECQKIPIHSLYRSIVNKGLAFGARHWICTLQQQCER 481 **********************************97 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
Gene3D	G3DSA:1.10.10.60	1.1E-21	73	134	IPR009057	Homeodomain-like
SuperFamily	SSF46689	1.92E-20	76	141	IPR009057	Homeodomain-like
PROSITE profile	PS50071	17.686	80	140	IPR001356	Homeobox domain
SMART	SM00389	5.2E-19	82	144	IPR001356	Homeobox domain
Pfam	PF00046	2.0E-18	83	138	IPR001356	Homeobox domain
CDD	cd00086	5.50E-16	87	138	No hit	No description
PROSITE pattern	PS00027	0	115	138	IPR017970	Homeobox, conserved site
PROSITE profile	PS50848	37.86	249	484	IPR002913	START domain
SuperFamily	SSF55961	4.4E-30	256	481	No hit	No description
SMART	SM00234	4.3E-50	258	481	IPR002913	START domain
CDD	cd08875	1.44E-92	261	480	No hit	No description
Pfam	PF01852	5.0E-45	262	481	IPR002913	START domain
Gene3D	G3DSA:3.30.530.20	1.7E-4	307	479	IPR023393	START-like domain
SuperFamily	SSF55961	3.3E-9	530	704	No hit	No description

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0006355	Biological Process	regulation of transcription, DNA-templated
GO:0009957	Biological Process	epidermal cell fate specification
GO:0010062	Biological Process	negative regulation of trichoblast fate specification
GO:0005634	Cellular Component	nucleus
GO:0008289	Molecular Function	lipid binding
GO:0043565	Molecular Function	sequence-specific DNA binding

Sequence ? help Back to Top
Protein Sequence Length: 743 aa Download sequence Send to blast
MSKLRRAFLP SPALSLSLAG IFQDGRSTAA SGEVETVEIS SENSGAGKYR SDEEEEEKHI 60 IDECDDDDEN CINGGEKKTK KKRKKYHRHT PEQITEMEAL FKESPHPDEN QRLQLSKQLG 120 LHPRQVKFWF QNRRTQIKAI QERHENSVLK TEMDKLRDEN KVLRETLKSP SCPNCGFATT 180 SGKESITAAT DEQRLRIENA TLKTEVEKLR SIIGKSSQGT SPNTSSCSPP GNINDQENRS 240 SFDFNTGNIG LERLRVKDTV KSALNELIKM ATHREPLWVP SYETGREILN YDEYTKQFGN 300 ENYYNKMQPN KSIEASKDSA IIFVDLLWLV RSFMDANRWQ ELFPCLISSA STVDVICNGE 360 GENGDGAVHL MFAEIQMLTP MVATREMYFF RHCKKVSTYQ WAIVDVSIDE DNIDASSQKC 420 RKRPSGCIIE DKSNGHCKVT WVEHIECQKI PIHSLYRSIV NKGLAFGARH WICTLQQQCE 480 RLVFHVATNV PVKDSSGVDT LAGRKSILTL SQRMSWSFCR AIGGSRRILW KKIVSKTGDD 540 IRVSLRNNLN EQGEPIGTIL SAVSSVWLPL SHHALFDFLR DENRRNEWDI MSNGSTVHST 600 VNLAKGQDRG NAVTVMDMKG EEQSVLVLQD SCTNAYESMV VYAPVDIKGL QSVMTGCDSS 660 KIPVLPSGFA IISDGIESRP FVFTSTRQDE KSTDGGSLLT VAFQILISNA TSAELSMDSV 720 DSVNTLISCT LQNIKRSLHC ED*

Sequence ? help Back to Top

Protein Sequence Length: 743 aa Download sequence Send to blast

MSKLRRAFLP SPALSLSLAG IFQDGRSTAA SGEVETVEIS SENSGAGKYR SDEEEEEKHI  60
IDECDDDDEN CINGGEKKTK KKRKKYHRHT PEQITEMEAL FKESPHPDEN QRLQLSKQLG  120
LHPRQVKFWF QNRRTQIKAI QERHENSVLK TEMDKLRDEN KVLRETLKSP SCPNCGFATT  180
SGKESITAAT DEQRLRIENA TLKTEVEKLR SIIGKSSQGT SPNTSSCSPP GNINDQENRS  240
SFDFNTGNIG LERLRVKDTV KSALNELIKM ATHREPLWVP SYETGREILN YDEYTKQFGN  300
ENYYNKMQPN KSIEASKDSA IIFVDLLWLV RSFMDANRWQ ELFPCLISSA STVDVICNGE  360
GENGDGAVHL MFAEIQMLTP MVATREMYFF RHCKKVSTYQ WAIVDVSIDE DNIDASSQKC  420
RKRPSGCIIE DKSNGHCKVT WVEHIECQKI PIHSLYRSIV NKGLAFGARH WICTLQQQCE  480
RLVFHVATNV PVKDSSGVDT LAGRKSILTL SQRMSWSFCR AIGGSRRILW KKIVSKTGDD  540
IRVSLRNNLN EQGEPIGTIL SAVSSVWLPL SHHALFDFLR DENRRNEWDI MSNGSTVHST  600
VNLAKGQDRG NAVTVMDMKG EEQSVLVLQD SCTNAYESMV VYAPVDIKGL QSVMTGCDSS  660
KIPVLPSGFA IISDGIESRP FVFTSTRQDE KSTDGGSLLT VAFQILISNA TSAELSMDSV  720
DSVNTLISCT LQNIKRSLHC ED*

Nucleic Localization Signal ? help Back to Top

No.	Start	End	Sequence
1	76	84	KKTKKKRKK
2	80	84	KKRKK

Functional Description ? help Back to Top
Source	Description
UniProt	Probable transcription factor required for correct morphological development and maturation of trichomes as well as for normal development of seed coat mucilage. Regulates the frequency of trichome initiation and determines trichome spacing. {ECO:0000269\|PubMed:11844112}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Migut.I00940.1.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Down-regulated by GEM. {ECO:0000269\|PubMed:17450124}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Nucleotide ? help Back to Top
Source	Hit ID	E-value	Description
GenBank	HQ197360	0.0	HQ197360.1 Mimulus guttatus pop-variant IM62 GLABRA2 (GL2) mRNA, partial cds.

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_012856110.1	0.0	PREDICTED: homeobox-leucine zipper protein GLABRA 2
Swissprot	P46607	0.0	HGL2_ARATH; Homeobox-leucine zipper protein GLABRA 2
TrEMBL	A0A022Q2R3	0.0	A0A022Q2R3_ERYGU; Uncharacterized protein

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Asterids	OGEA6228	23	28

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G79840.1	0.0	HD-ZIP family protein

Link Out ? help Back to Top
Phytozome	Migut.I00940.1.p
Entrez Gene	105975457

Publications ? help Back to Top
Scoville AG,Barnett LL,Bodbyl-Roels S,Kelly JK,Hileman LC Differential regulation of a MYB transcription factor is correlated with transgenerational epigenetic inheritance of trichome density in Mimulus guttatus. New Phytol., 2011. 191(1): p. 251-63 [PMID:21352232] Wu R,Citovsky V Adaptor proteins GIR1 and GIR2. I. Interaction with the repressor GLABRA2 and regulation of root hair development. Biochem. Biophys. Res. Commun., 2017. 488(3): p. 547-553 [PMID:28526410]