PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Medtr6g477820.1
Common NameMTR_6g477820
Organism
Medicago truncatula
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
Family HD-ZIP
Protein Properties Length: 729aa    MW: 80587.5 Da    PI: 6.809
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Medtr6g477820.1genomeMtView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox59.94e-193085156
                     TT--SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHCTS-HHHHHHHHHHHHHHHH CS
         Homeobox  1 rrkRttftkeqleeLeelFeknrypsaeereeLAkklgLterqVkvWFqNrRakek 56
                     +++ +++t++q+++Le++F+++++p++++r +L+++l L  rq+k+WFqNrR+++k
  Medtr6g477820.1 30 KKRYHRHTANQIQRLEAMFKECPHPDEKQRLQLSRELALAPRQIKFWFQNRRTQMK 85
                     678899***********************************************998 PP
2START171.74.6e-542304542206
                      HHHHHHHHHHHHHHHC-TT-EEEE....EXCCTTEEEEEEESSS.......SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-S....EEEE CS
            START   2 laeeaaqelvkkalaeepgWvkss....esengdevlqkfeeskv......dsgealrasgvvdmvlallveellddkeqWdetla....kaet 81 
                      +a  a++e +++ + +ep+W+ks     + +n + + + f+++ +       ++ea+r+s+vv+m+   lve ++d + qW   ++     a t
  Medtr6g477820.1 230 IASNAMEEMIRLLQTNEPLWMKSNsdgkDVLNLENYERMFPKTTNrlknpnIRIEASRDSRVVIMNGLALVEMFMDPN-QWMALFPtivtMART 322
                      67889*******************8888667777777777666668888989**************************.999999888889*** PP

                      EEEECTT......EEEEEEEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--.-TTSEE-EESSEEEEEEEECTCEEEEEEEE CS
            START  82 levissg......galqlmvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppesssvvRaellpSgiliepksnghskvtwve 168
                      +evissg      g  qlm+ elq+lsplvp R+f+f+Ry+ q ++g w+ivdvS d + +++  ++  R+++lpSg+ i++++ng+skvtw+e
  Medtr6g477820.1 323 IEVISSGmmggpsGSMQLMYEELQVLSPLVPiREFYFLRYCTQIEQGLWAIVDVSYDFPHDNQ-FAPQFRCHRLPSGCFIQDMPNGYSKVTWIE 415
                      **************************************************************9.8***************************** PP

                      -EE--SSXX.HHHHHHHHHHHHHHHHHHHHHHTXXXXXX CS
            START 169 hvdlkgrlp.hwllrslvksglaegaktwvatlqrqcek 206
                      h + +++ p h  +r  + sg+a+ga +w+ tlqr ce+
  Medtr6g477820.1 416 HLEIEDKNPvHRFYRNAIYSGAAFGAERWLTTLQRMCER 454
                      *************************************97 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF466898.77E-20787IPR009057Homeodomain-like
Gene3DG3DSA:1.10.10.608.9E-211589IPR009057Homeodomain-like
PROSITE profilePS5007117.6862787IPR001356Homeobox domain
SMARTSM003892.8E-172891IPR001356Homeobox domain
CDDcd000863.37E-172988No hitNo description
PfamPF000469.9E-173085IPR001356Homeobox domain
PROSITE patternPS0002706285IPR017970Homeobox, conserved site
PROSITE profilePS5084849.254220457IPR002913START domain
SuperFamilySSF559615.19E-35221455No hitNo description
CDDcd088751.02E-114224453No hitNo description
SMARTSM002341.4E-39229454IPR002913START domain
PfamPF018523.0E-46230454IPR002913START domain
Gene3DG3DSA:3.30.530.206.0E-7291420IPR023393START-like domain
SuperFamilySSF559617.14E-21473649No hitNo description
SuperFamilySSF559617.14E-21681718No hitNo description
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0009828Biological Processplant-type cell wall loosening
GO:0010091Biological Processtrichome branching
GO:0005634Cellular Componentnucleus
GO:0000976Molecular Functiontranscription regulatory region sequence-specific DNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
GO:0008289Molecular Functionlipid binding
Sequence ? help Back to Top
Protein Sequence    Length: 729 aa     Download sequence    Send to blast
MEYHSGGSGS PGDHHHHHHH EGSSESQRRK KRYHRHTANQ IQRLEAMFKE CPHPDEKQRL  60
QLSRELALAP RQIKFWFQNR RTQMKAQHER ADNCQLRAEN DKIRCENIAI REALKNVICP  120
SCGGPPINDD CFFDEQKLRI ENVQLKEELD RVSSIAAKYI GRPITQLPPV APIHISSLDL  180
SMGNFGGQGM IGGGPSLDLD LLPGSSSTMQ NIPYQPACLS DMEKSLMSDI ASNAMEEMIR  240
LLQTNEPLWM KSNSDGKDVL NLENYERMFP KTTNRLKNPN IRIEASRDSR VVIMNGLALV  300
EMFMDPNQWM ALFPTIVTMA RTIEVISSGM MGGPSGSMQL MYEELQVLSP LVPIREFYFL  360
RYCTQIEQGL WAIVDVSYDF PHDNQFAPQF RCHRLPSGCF IQDMPNGYSK VTWIEHLEIE  420
DKNPVHRFYR NAIYSGAAFG AERWLTTLQR MCERIACSMV SATRDLGGAI PSPEGKSSMM  480
KLAQKMVTSF CASISASASH RWTTLSSLNE TGVRVTVRKS TELGQPSGVV LCAATTIWLP  540
LPPQTVFNFF KDERKRSQWD VLSNGNAVQE VAHIANGSHP GNSISVLRAF NTSQNNMLIL  600
QESCVDSSGS IVVYCPIELT SMNVAMSGED TSHIPVTPSG FTITSDGNTL DNNNNLQGSG  660
NVNADGASTS SNLGNNGGSG GSLITVAFQI MVSSLPSAKL NMESVATVNG LIGETVQHIK  720
AALNCPSS*
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: During embryo development, expressed in all cells at the 4- and 16-cell embryo stages. Expression is restricted to the protoderm from the globular stage onward. {ECO:0000269|PubMed:25564655}.
UniprotTISSUE SPECIFICITY: Expressed in apical meristems and young epidermal tissue including trichomes and stipules. Expressed in lateral root tips, the L1 layer of apical inflorescence meristems and early flower primordia, carpel and petal epidermis, stigma papillae, ovule primordia, nucellus and embryo. {ECO:0000269|PubMed:16778018}.
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor which acts as positive regulator of drought stress tolerance. Can transactivate CIPK3, NCED3 and ERECTA (PubMed:18451323). Transactivates several cell-wall-loosening protein genes by directly binding to HD motifs in their promoters. These target genes play important roles in coordinating cell-wall extensibility with root development and growth (PubMed:24821957). Transactivates CYP74A/AOS, AOC3, OPR3 and 4CLL5/OPCL1 genes by directly binding to HD motifs in their promoters. These target genes are involved in jasmonate (JA) biosynthesis, and JA signaling affects root architecture by activating auxin signaling, which promotes lateral root formation (PubMed:25752924). Acts as negative regulator of trichome branching (PubMed:16778018, PubMed:24824485). Required for the establishment of giant cell identity on the abaxial side of sepals (PubMed:23095885). May regulate cell differentiation and proliferation during root and shoot meristem development (PubMed:25564655). {ECO:0000269|PubMed:16778018, ECO:0000269|PubMed:18451323, ECO:0000269|PubMed:23095885, ECO:0000269|PubMed:24821957, ECO:0000269|PubMed:24824485, ECO:0000269|PubMed:25564655, ECO:0000269|PubMed:25752924}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00232DAPTransfer from AT1G73360Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapMedtr6g477820.1
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAP0150443e-57AP015044.1 Vigna angularis var. angularis DNA, chromosome 11, almost complete sequence, cultivar: Shumari.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013452816.10.0homeobox-leucine zipper protein HDG11
SwissprotQ9FX310.0HDG11_ARATH; Homeobox-leucine zipper protein HDG11
TrEMBLA0A072UAM90.0A0A072UAM9_MEDTR; Homeobox leucine zipper protein
STRINGXP_004515249.10.0(Cicer arietinum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF10263398
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G73360.10.0homeodomain GLABROUS 11
Publications ? help Back to Top
  1. Duarte JM, et al.
    Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis.
    Mol. Biol. Evol., 2006. 23(2): p. 469-78
    [PMID:16280546]
  2. Young ND, et al.
    The Medicago genome provides insight into the evolution of rhizobial symbioses.
    Nature, 2011. 480(7378): p. 520-4
    [PMID:22089132]
  3. Khosla A, et al.
    HD-Zip Proteins GL2 and HDG11 Have Redundant Functions in Arabidopsis Trichomes, and GL2 Activates a Positive Feedback Loop via MYB23.
    Plant Cell, 2014. 26(5): p. 2184-2200
    [PMID:24824485]
  4. Horstman A, et al.
    AIL and HDG proteins act antagonistically to control cell proliferation.
    Development, 2015. 142(3): p. 454-64
    [PMID:25564655]
  5. Cai XT,Xu P,Wang Y,Xiang CB
    Activated expression of AtEDT1/HDG11 promotes lateral root formation in Arabidopsis mutant edt1 by upregulating jasmonate biosynthesis.
    J Integr Plant Biol, 2015. 57(12): p. 1017-30
    [PMID:25752924]
  6. Yu LH, et al.
    Arabidopsis EDT1/HDG11 improves drought and salt tolerance in cotton and poplar and increases cotton yield in the field.
    Plant Biotechnol. J., 2016. 14(1): p. 72-84
    [PMID:25879154]
  7. Zhu Z, et al.
    Overexpression of AtEDT1/HDG11 in Chinese Kale (Brassica oleracea var. alboglabra) Enhances Drought and Osmotic Stress Tolerance.
    Front Plant Sci, 2016. 7: p. 1285
    [PMID:27625663]
  8. Liu Y, et al.
    Overexpression of AtEDT1 promotes root elongation and affects medicinal secondary metabolite biosynthesis in roots of transgenic Salvia miltiorrhiza.
    Protoplasma, 2017. 254(4): p. 1617-1625
    [PMID:27915455]
  9. Ueda M, et al.
    Transcriptional integration of paternal and maternal factors in the Arabidopsis zygote.
    Genes Dev., 2017. 31(6): p. 617-627
    [PMID:28404632]
  10. Lung SC, et al.
    Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.
    New Phytol., 2018. 218(1): p. 183-200
    [PMID:29288621]
  11. Zheng G, et al.
    Over-Expression of Arabidopsis EDT1 Gene Confers Drought Tolerance in Alfalfa (Medicago sativa L.).
    Front Plant Sci, 2017. 8: p. 2125
    [PMID:29326737]