PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Medtr4g106540.3
Common NameMTR_4g106540
Organism
Medicago truncatula
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
Family E2F/DP
Protein Properties Length: 386aa    MW: 43378.6 Da    PI: 8.2807
Description E2F/DP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Medtr4g106540.3genomeMtView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1E2F_TDP78.37.4e-251782171
          E2F_TDP  1 rkeksLrlltqkflkllekseegivtlnevakeLvsedvknkrRRiYDilNVLealnliekkekneirwkg 71
                     rk+ksL+ll+++fl+l++k + + + l+++a +L    v  +rRRiYDi+NVLe+++++++k+kn+++wkg
  Medtr4g106540.3 17 RKQKSLGLLCTNFLSLYNKDDVRLIGLDDAAAKL---GV--ERRRIYDIVNVLESIGVLARKAKNQYTWKG 82
                     79*****************999************...**..****************************98 PP
2E2F_TDP75.55.3e-24161241171
          E2F_TDP   1 rkeksLrlltqkflkllekseegivtlnevakeLvse.....dvknkrRRiYDilNVLealnliek.....kekneirwkg 71 
                      r+eksL lltq+f+kl+ +s+ ++++l+++a+ L+ +      +++k+RR+YDi+NVL+++nliek     ++k+++rw g
  Medtr4g106540.3 161 RREKSLALLTQNFVKLFVCSNLEMISLDDAARLLLGDaynssTMRTKVRRLYDIANVLTSMNLIEKthttdTRKPAFRWLG 241
                      689*******************************************************************99*******87 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:1.10.10.101.2E-251383IPR011991Winged helix-turn-helix DNA-binding domain
SuperFamilySSF467854.17E-161680IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.0E-281782IPR003316E2F/DP family, winged-helix DNA-binding domain
PfamPF023192.3E-201882IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene3DG3DSA:1.10.10.105.0E-23158243IPR011991Winged helix-turn-helix DNA-binding domain
SMARTSM013723.7E-29161241IPR003316E2F/DP family, winged-helix DNA-binding domain
SuperFamilySSF467852.05E-13163242IPR011991Winged helix-turn-helix DNA-binding domain
PfamPF023192.0E-19163241IPR003316E2F/DP family, winged-helix DNA-binding domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0032876Biological Processnegative regulation of DNA endoreduplication
GO:0005634Cellular Componentnucleus
GO:0005667Cellular Componenttranscription factor complex
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 386 aa     Download sequence    Send to blast
MAASSSDPPS RHHTYDRKQK SLGLLCTNFL SLYNKDDVRL IGLDDAAAKL GVERRRIYDI  60
VNVLESIGVL ARKAKNQYTW KGFAAIPVAL QELKEEGLWQ NLNSSQEGAN EDVKVSDEED  120
EDELLSQTTG SQGESLSQPT GSQNDNLNPN SAFPRSLKND RREKSLALLT QNFVKLFVCS  180
NLEMISLDDA ARLLLGDAYN SSTMRTKVRR LYDIANVLTS MNLIEKTHTT DTRKPAFRWL  240
GLKGKTLNEA SLYNSKQNES RKRAFGNDVT NISFARNRMD LFMGGDFKKQ KTMENDSGLC  300
QEDVKQGIKQ TSAANYQFGP FAPAFVSKAG SSENKVKQVH DWESLATEHC PQYQNQALKE  360
LYSHYMEAWK SWYSEVAGKR STQVL*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
4yo2_A3e-40172334228Transcription factor E2F8
Search in ModeBase
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed in a cell cycle-dependent manner. Not detected during early S phase. Expressed at both the G1/S and S/G2 transitions, with a peak during G2. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:18787127}.
UniprotTISSUE SPECIFICITY: Expressed exclusively in mitotically dividing cells. Highly expressed in young leaves and mature flowers. Lower expression in young stalk and in young and mature flowers. {ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366}.
Functional Description ? help Back to Top
Source Description
UniProtInhibitor of E2F-dependent activation of gene expression. Binds specifically the E2 recognition site without interacting with DP proteins and prevents transcription activation by E2F/DP heterodimers. Controls the timing of endocycle onset and inhibits endoreduplication. {ECO:0000269|PubMed:11786543, ECO:0000269|PubMed:11867638, ECO:0000269|PubMed:15649366, ECO:0000269|PubMed:18787127}.
Binding Motif ? help Back to Top
Motif ID Method Source Motif file
MP00397DAPTransfer from AT3G48160Download
Motif logo
Cis-element ? help Back to Top
SourceLink
PlantRegMapMedtr4g106540.3
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieveRetrieve
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankAC1368390.0AC136839.21 Medicago truncatula chromosome 8 clone mth2-13n2, complete sequence.
GenBankAC1469140.0AC146914.9 Medicago truncatula chromosome 8 clone mth2-57l14, complete sequence.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013457830.10.0E2F transcription factor-like E2FE isoform X2
SwissprotQ8LSZ41e-123E2FE_ARATH; E2F transcription factor-like E2FE
TrEMBLA0A072URB00.0A0A072URB0_MEDTR; E2F transcription factor-E2FE-like protein
STRINGAES911280.0(Medicago truncatula)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36683366
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT3G48160.21e-113DP-E2F-like 1
Publications ? help Back to Top
  1. Young ND, et al.
    The Medicago genome provides insight into the evolution of rhizobial symbioses.
    Nature, 2011. 480(7378): p. 520-4
    [PMID:22089132]
  2. Chandran D, et al.
    Atypical E2F transcriptional repressor DEL1 acts at the intersection of plant growth and immunity by controlling the hormone salicylic acid.
    Cell Host Microbe, 2014. 15(4): p. 506-13
    [PMID:24721578]
  3. Wang Z, et al.
    Del1 Knockout Mice Developed More Severe Osteoarthritis Associated with Increased Susceptibility of Chondrocytes to Apoptosis.
    PLoS ONE, 2016. 11(8): p. e0160684
    [PMID:27505251]
  4. Heyman J,Polyn S,Eekhout T,De Veylder L
    Tissue-Specific Control of the Endocycle by the Anaphase Promoting Complex/Cyclosome Inhibitors UVI4 and DEL1.
    Plant Physiol., 2017. 175(1): p. 303-313
    [PMID:28698355]