PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Medtr4g058970.1
Common NameMTR_4g058970
Organism
Medicago truncatula
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Fabales; Fabaceae; Papilionoideae; Trifolieae; Medicago
Family HD-ZIP
Protein Properties Length: 847aa    MW: 92661.6 Da    PI: 6.1404
Description HD-ZIP family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Medtr4g058970.1genomeMtView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1Homeobox581.6e-182886357
                     --SS--HHHHHHHHHHHHHSSS--HHHHHHHHHHC....TS-HHHHHHHHHHHHHHHHC CS
         Homeobox  3 kRttftkeqleeLeelFeknrypsaeereeLAkkl....gLterqVkvWFqNrRakekk 57
                     k  ++t+eq+e+Le++++++++ps  +r++L +++    +++ +q+kvWFqNrR +ek+
  Medtr4g058970.1 28 KYVRYTSEQVEALERVYAECPKPSSMRRQQLIRECpilsNIEPKQIKVWFQNRRCREKQ 86
                     56789****************************************************97 PP
2START156.42.4e-491673742204
                      HHHHHHHHHHHHHHHC-TT-EEEEEXCCTTEEEEEEESSS.SCEEEEEEEECCSCHHHHHHHHHCCCGGCT-TT-SEEEEEEEECTT..EEEEE CS
            START   2 laeeaaqelvkkalaeepgWvkssesengdevlqkfeeskvdsgealrasgvvdmvlallveellddkeqWdetlakaetlevissg..galql 93 
                      +aee+++e+++ka+ ++  Wv+++ +++g++++ +f+ s+++sg a+ra+g+v  +++   +e+l+d++ W + ++  e+      g  g+++l
  Medtr4g058970.1 167 IAEETLTEFLSKATGTAVDWVQMPGMKPGPDSVGIFAISQSCSGVAARACGLVSLEPT-KIAEILKDRLSWFRECRNLEVFTMFPAGngGTIEL 259
                      789*******************************************************.8888888888*******9999999998888***** PP

                      EEEXXTTXX-SSX.EEEEEEEEEEE.TTS-EEEEEEEEE-TTS--....-TTSEE-EESSEEEEEEEECTCEEEEEEEE-EE--SSXXHHHHHH CS
            START  94 mvaelqalsplvp.RdfvfvRyirqlgagdwvivdvSvdseqkppe...sssvvRaellpSgiliepksnghskvtwvehvdlkgrlphwllrs 183
                      ++++++a+++l+p Rdf+++Ry+ +l  g++v++++S++     p+    +++vRae+lpSg+li+p+++g+s +++v+h +l+ ++++++lr+
  Medtr4g058970.1 260 IYTQTYAPTTLAPaRDFWTLRYTTTLDNGSLVVCERSLSGSGTGPNptaAAQFVRAEMLPSGYLIRPCDGGGSIIHIVDHLNLEPWSVPEVLRP 353
                      **************************************987666666799******************************************** PP

                      HHHHHHHHHHHHHHHHTXXXX CS
            START 184 lvksglaegaktwvatlqrqc 204
                      l++s  + ++k++ a+l++ +
  Medtr4g058970.1 354 LYESPKVVAQKMTIAALRYIR 374
                      ****************99865 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
PROSITE profilePS5007115.4512387IPR001356Homeobox domain
SMARTSM003896.0E-162591IPR001356Homeobox domain
SuperFamilySSF466891.63E-162790IPR009057Homeodomain-like
CDDcd000861.43E-162888No hitNo description
PfamPF000463.7E-162986IPR001356Homeobox domain
Gene3DG3DSA:1.10.10.602.0E-183086IPR009057Homeodomain-like
CDDcd146862.37E-680119No hitNo description
PROSITE profilePS5084826.221157385IPR002913START domain
CDDcd088756.90E-69161377No hitNo description
SuperFamilySSF559611.79E-33166378No hitNo description
Gene3DG3DSA:3.30.530.201.2E-18166349IPR023393START-like domain
SMARTSM002345.8E-40166376IPR002913START domain
PfamPF018527.6E-47167374IPR002913START domain
PfamPF086702.0E-50702845IPR013978MEKHLA
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0009855Biological Processdetermination of bilateral symmetry
GO:0009944Biological Processpolarity specification of adaxial/abaxial axis
GO:0009956Biological Processradial pattern formation
GO:0010014Biological Processmeristem initiation
GO:0010051Biological Processxylem and phloem pattern formation
GO:0010089Biological Processxylem development
GO:0030154Biological Processcell differentiation
GO:0005634Cellular Componentnucleus
GO:0008289Molecular Functionlipid binding
GO:0044212Molecular Functiontranscription regulatory region DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 847 aa     Download sequence    Send to blast
MAMAMAVAHH RESSSSGGSI DKHLDSGKYV RYTSEQVEAL ERVYAECPKP SSMRRQQLIR  60
ECPILSNIEP KQIKVWFQNR RCREKQRKEA SRLQTVNRKL SAMNKLLMEE NDRLQKQVSQ  120
LVCENGFMRQ QLHTPSAANT DASCDSVVTT PQNSKRDATN PAGLLSIAEE TLTEFLSKAT  180
GTAVDWVQMP GMKPGPDSVG IFAISQSCSG VAARACGLVS LEPTKIAEIL KDRLSWFREC  240
RNLEVFTMFP AGNGGTIELI YTQTYAPTTL APARDFWTLR YTTTLDNGSL VVCERSLSGS  300
GTGPNPTAAA QFVRAEMLPS GYLIRPCDGG GSIIHIVDHL NLEPWSVPEV LRPLYESPKV  360
VAQKMTIAAL RYIRQIAQES SGEVVYGLGR QPAVLRTFSQ RLSRGFNDAV NGFSDDGWSI  420
LNCDGAEDVI IAVNSTKNLS SSSNPASSLT LLGGILCAKA SMLLQNVPPA VLVRFLREHR  480
SEWADFNVDA YSAASLKAGT YAYPGMRPTR FTGNQIIMPL GNTIEHEEML EVIRLEGHSL  540
AQEDAFVSRD IHLLQICSGT DENAVGTCSE LIFAPIDEMF PDDAPLVPSG FRIIPLDSKP  600
GDKKDAVNTN RTLDLTSGLE VSPATTHGGA DSSSSQNTRS VLTIAFQFPF DSTMQDNVVI  660
MARQYVRSVI ASVQRVAMAI SPSGINPAVG AKLSPGSPEA VTLAQWICQS YSYYLGTDLL  720
RSDSLVGDLM LKQLWHHQDA ILCCSLKSQP VFVFANQAGL DMLETTLVAL QDITLDKIFD  780
ESGRKALCAD FAKLMQQGFA YLPAGICMST MGRHVSYEQA IAWKVLTPED NTVHCLAFSF  840
INWSFV*
Expression -- UniGene ? help Back to Top
UniGene ID E-value Expressed in
Mtr.128040.0root| stem
Expression -- Description ? help Back to Top
Source Description
UniprotDEVELOPMENTAL STAGE: Expressed at the earliest stages and throughout LSM initiation and development. In embryo development, expressed at the heart stage until the 'walking stick' stage in the adaxial portion of the cotyledon primordia, the shoot apical meristem (SAM) and the vascular precursor cells of the hypocotyl and root. In developing flowers, expressed first at stage 1 in the center of L3 layer and then expands to the center of L2 and L1 layers. Expressed in the center of flower meristem through stages 4 and 5. At stage 6, expressed in the adaxial side of the carpel primordia and then on the adaxial carpel face. {ECO:0000269|PubMed:11169198}.
UniprotTISSUE SPECIFICITY: Expressed in the interfascicular regions of stem and vascular bundles of young roots and leaves. {ECO:0000269|PubMed:10559440}.
Functional Description ? help Back to Top
Source Description
UniProtProbable transcription factor involved in the regulation of interfascicular fiber (cortical cells) and secondary xylem differentiation in the inflorescence stems. Required for lateral shoot meristems (LSMs) and flower meristems (FMs) initiation. May be involved in the determination of vascular patterning and organ polarity (PubMed:10559440, PubMed:11169198, PubMed:11402186, PubMed:15111711, PubMed:15598805, PubMed:7555701). Directly regulates the expression of AGO10, ZPR1, ZPR2, ZPR3 and ZPR4 (PubMed:22781836). Required to regulate adaxial-abaxial polarity and leaf axial patterning (PubMed:20807212). {ECO:0000269|PubMed:10559440, ECO:0000269|PubMed:11169198, ECO:0000269|PubMed:11402186, ECO:0000269|PubMed:15111711, ECO:0000269|PubMed:15598805, ECO:0000269|PubMed:20807212, ECO:0000269|PubMed:22781836, ECO:0000269|PubMed:7555701}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapMedtr4g058970.1
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By auxin. Repressed by ZPR and miR165. Induced by DOF5.1 (PubMed:20807212). {ECO:0000269|PubMed:15111711, ECO:0000269|PubMed:17237362, ECO:0000269|PubMed:20807212}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_013456006.10.0homeobox-leucine zipper protein REVOLUTA
SwissprotQ9SE430.0REV_ARATH; Homeobox-leucine zipper protein REVOLUTA
TrEMBLA0A072UK130.0A0A072UK13_MEDTR; Class III homeodomain leucine zipper protein
STRINGXP_004505999.10.0(Cicer arietinum)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF66333147
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G60690.10.0HD-ZIP family protein
Publications ? help Back to Top
  1. Young ND, et al.
    The Medicago genome provides insight into the evolution of rhizobial symbioses.
    Nature, 2011. 480(7378): p. 520-4
    [PMID:22089132]
  2. Lian H,Li X,Liu Z,He Y
    HYL1 is required for establishment of stamen architecture with four microsporangia in Arabidopsis.
    J. Exp. Bot., 2013. 64(11): p. 3397-410
    [PMID:23918970]
  3. Ding Y, et al.
    Four distinct types of dehydration stress memory genes in Arabidopsis thaliana.
    BMC Plant Biol., 2013. 13: p. 229
    [PMID:24377444]
  4. Baima S, et al.
    Negative feedback regulation of auxin signaling by ATHB8/ACL5-BUD2 transcription module.
    Mol Plant, 2014. 7(6): p. 1006-1025
    [PMID:24777988]
  5. Jia X, et al.
    Functional plasticity of miR165/166 in plant development revealed by small tandem target mimic.
    Plant Sci., 2015. 233: p. 11-21
    [PMID:25711809]
  6. Roodbarkelari F,Du F,Truernit E,Laux T
    ZLL/AGO10 maintains shoot meristem stem cells during Arabidopsis embryogenesis by down-regulating ARF2-mediated auxin response.
    BMC Biol., 2015. 13: p. 74
    [PMID:26358077]
  7. Shi B, et al.
    Two-Step Regulation of a Meristematic Cell Population Acting in Shoot Branching in Arabidopsis.
    PLoS Genet., 2016. 12(7): p. e1006168
    [PMID:27398935]