PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.18G100800.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family NAC
Protein Properties Length: 316aa    MW: 36127.4 Da    PI: 6.7192
Description NAC family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.18G100800.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1NAM166.21.1e-5171351128
                  NAM   1 lppGfrFhPtdeelvveyLkkkvegkkleleevikevdiykvePwdLpk..kvka...eekewyfFskrdkkyatgkrknratksgyWka 85 
                          +ppGfrF Pt+eelv +yLk+k+++ k++l +vi ++d+yk+ePwd+++  k      e++ewyfFs++d+ky+tg+r+nrat++g+Wka
  Manes.18G100800.1.p   7 VPPGFRFFPTEEELVGYYLKRKINSLKIDL-DVIIDIDLYKIEPWDIQArcK--LgydEQNEWYFFSHKDRKYPTGTRTNRATATGFWKA 93 
                          69****************************.99**************96342..3333677***************************** PP

                  NAM  86 tgkdkevlskkgelvglkktLvfykgrapkgektdWvmheyrl 128
                          tg+dk+vls k++ +g++ktLvfykgrap+g+ktdW++heyrl
  Manes.18G100800.1.p  94 TGRDKAVLS-KNKIIGMRKTLVFYKGRAPNGRKTDWIVHEYRL 135
                          *********.8999***************************98 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF1019412.35E-585156IPR003441NAC domain
PROSITE profilePS5100557.0827156IPR003441NAC domain
PfamPF023651.9E-268135IPR003441NAC domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0005634Cellular Componentnucleus
GO:0003677Molecular FunctionDNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 316 aa     Download sequence    Send to blast
MEMESCVPPG FRFFPTEEEL VGYYLKRKIN SLKIDLDVII DIDLYKIEPW DIQARCKLGY  60
DEQNEWYFFS HKDRKYPTGT RTNRATATGF WKATGRDKAV LSKNKIIGMR KTLVFYKGRA  120
PNGRKTDWIV HEYRLQTSEH GPPQEEGWVV CRAFKKPIPS QRPNYNEAWN NNPAFSANIS  180
PQAFSDTVAT THMPIQTNQT ASFHQQQQQQ PFGSDPADQV VSSHPFLENN KLINLPQLDS  240
PSTLSTSFAT REVLHNINGV SSEDFDKERS NNTNSTQFID WKNLDSLLAS QVNDSMPSMP  300
QSYEISHFLG CFPDS*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
1ut4_A1e-48716217171NO APICAL MERISTEM PROTEIN
1ut4_B1e-48716217171NO APICAL MERISTEM PROTEIN
1ut7_A1e-48716217171NO APICAL MERISTEM PROTEIN
1ut7_B1e-48716217171NO APICAL MERISTEM PROTEIN
3swm_A2e-48716220174NAC domain-containing protein 19
3swm_B2e-48716220174NAC domain-containing protein 19
3swm_C2e-48716220174NAC domain-containing protein 19
3swm_D2e-48716220174NAC domain-containing protein 19
3swp_A2e-48716220174NAC domain-containing protein 19
3swp_B2e-48716220174NAC domain-containing protein 19
3swp_C2e-48716220174NAC domain-containing protein 19
3swp_D2e-48716220174NAC domain-containing protein 19
4dul_A1e-48716217171NAC domain-containing protein 19
4dul_B1e-48716217171NAC domain-containing protein 19
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription activator that binds to the secondary wall NAC binding element (SNBE), 5'-(T/A)NN(C/T)(T/C/G)TNNNNNNNA(A/C)GN(A/C/T)(A/T)-3', in the promoter of target genes (e.g. genes involved in secondary wall biosynthesis, cell wall modification such as xylan accumulation, and programmed cell death) (PubMed:20935069, PubMed:20488898, PubMed:22037706, PubMed:21284754). Involved in xylem formation in roots and shoots, especially regulating protoxylem vessel differentiation by promoting immature xylem vessel-specific genes expression (PubMed:16103214, PubMed:18445131, PubMed:20488898, PubMed:21498679, PubMed:21284754). Can activate the expression of several genes including XCP1, MYB46, NAC010/SND3, MYB103, MYB58, MYB63, MYB83, KNAT7, ASL19 and ASL20 (PubMed:17890373, PubMed:19088331, PubMed:18952777, PubMed:19122102, PubMed:19808805, PubMed:20935069, PubMed:21284754). {ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:17890373, ECO:0000269|PubMed:18445131, ECO:0000269|PubMed:18952777, ECO:0000269|PubMed:19088331, ECO:0000269|PubMed:19122102, ECO:0000269|PubMed:19808805, ECO:0000269|PubMed:20488898, ECO:0000269|PubMed:20935069, ECO:0000269|PubMed:21284754, ECO:0000269|PubMed:21498679, ECO:0000269|PubMed:22037706}.; FUNCTION: Required for the soilborne fungal pathogen Verticillium longisporum-induced transdifferentiation of chloroplast-containing bundle sheath cells to functional xylem elements leading to stunted growth, vein clearing, and leaf chloroses, as well as xylem hyperplasia within the vasculature of leaves, hypocotyls, and roots due to reinitiation of cambial activity and transdifferentiation of xylem parenchyma cells. This developmental reprogramming mediates also an increased drought stress tolerance. {ECO:0000269|PubMed:23023171}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.18G100800.1.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: By brassinosteroids (e.g. brassinolide BL), auxin (e.g. 2,4-dichlorphenoxyacetic acid 2,4-D) and cytokinin (e.g. kinetin), with a synergistic effect (PubMed:16103214, PubMed:22345435). Up-regulated in a feed-back loop by ASL20 (PubMed:19088331). Levels are monitored by proteasome-mediated degradation (PubMed:18445131). Repressed by WEE1 upon replication stress to prevent premature tracheary element differentiation (PubMed:21498679). Accumulates during infection by the soilborne fungal pathogen Verticillium longisporum, especially in tissues undergoing de novo xylem formation (PubMed:23023171). {ECO:0000269|PubMed:16103214, ECO:0000269|PubMed:18445131, ECO:0000269|PubMed:19088331, ECO:0000269|PubMed:21498679, ECO:0000269|PubMed:22345435, ECO:0000269|PubMed:23023171}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Nucleotide ? help Back to Top
Source Hit ID E-value Description
GenBankKR6052340.0KR605234.1 Manihot esculenta NAC transcription factors 96 mRNA, complete cds.
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021601879.10.0NAC domain-containing protein 30-like
SwissprotQ9C8W91e-120NAC30_ARATH; NAC domain-containing protein 30
TrEMBLA0A0M4FP500.0A0A0M4FP50_MANES; NAC transcription factors 96
STRINGcassava4.1_034391m0.0(Manihot esculenta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF71383247
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT1G71930.11e-104vascular related NAC-domain protein 7
Publications ? help Back to Top
  1. Heyndrickx KS,Vandepoele K
    Systematic identification of functional plant modules through the integration of complementary data sources.
    Plant Physiol., 2012. 159(3): p. 884-901
    [PMID:22589469]
  2. Kakehi J, et al.
    Mutations in ribosomal proteins, RPL4 and RACK1, suppress the phenotype of a thermospermine-deficient mutant of Arabidopsis thaliana.
    PLoS ONE, 2015. 10(1): p. e0117309
    [PMID:25625317]
  3. Hu W, et al.
    Genome-Wide Identification and Expression Analysis of the NAC Transcription Factor Family in Cassava.
    PLoS ONE, 2015. 10(8): p. e0136993
    [PMID:26317631]
  4. Li Z, et al.
    A Transcriptional and Metabolic Framework for Secondary Wall Formation in Arabidopsis.
    Plant Physiol., 2016. 172(2): p. 1334-1351
    [PMID:27566165]
  5. de Lucas M, et al.
    Transcriptional Regulation of Arabidopsis Polycomb Repressive Complex 2 Coordinates Cell-Type Proliferation and Differentiation.
    Plant Cell, 2016. 28(10): p. 2616-2631
    [PMID:27650334]
  6. Tan TT, et al.
    Transcription Factors VND1-VND3 Contribute to Cotyledon Xylem Vessel Formation.
    Plant Physiol., 2018. 176(1): p. 773-789
    [PMID:29133368]
  7. Ohashi-Ito K,Iwamoto K,Fukuda H
    LOB DOMAIN-CONTAINING PROTEIN 15 Positively Regulates Expression of VND7, a Master Regulator of Tracheary Elements.
    Plant Cell Physiol., 2018. 59(5): p. 989-996
    [PMID:29444288]