PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot

Family

C2H2

Protein Properties

Length: 473aa MW: 51710.5 Da PI: 6.0912

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Manes.15G133200.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	14.5	0.00011	126	148	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 y+Cp+Cg+s+++ ++ H ++ Manes.15G133200.1.p 126 YECPICGQSYKSEEEVSMHVESC 148 99***************998776 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
CDD	cd09212	8.79E-20	185	268	No hit	No description
SMART	SM00580	1.5E-17	186	253	IPR018997	PUB domain
SuperFamily	SSF143503	2.22E-17	186	269	IPR018997	PUB domain
Pfam	PF09409	8.8E-16	188	260	IPR018997	PUB domain
SuperFamily	SSF54236	1.99E-12	336	447	IPR029071	Ubiquitin-related domain
SMART	SM00166	0.0058	359	449	IPR001012	UBX domain
PROSITE profile	PS50033	10.71	363	447	IPR001012	UBX domain
Gene3D	G3DSA:3.10.20.90	2.5E-8	363	446	No hit	No description
Pfam	PF00789	6.0E-5	364	414	IPR001012	UBX domain

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0050832	Biological Process	defense response to fungus
GO:0005515	Molecular Function	protein binding

Sequence ? help Back to Top
Protein Sequence Length: 473 aa Download sequence Send to blast
MDDMKDKFKG FMKKVNTQLS SSSSGKFKGQ GRVLGGSSSA SSGSNNPIGS RYYQPDNPKP 60 TPTPSSLNSS SNFKSLPQKT PNSDQNKPAP INNSIPNRKP VDGFDPFDSL ITTGKRSQNG 120 SSLNVYECPI CGQSYKSEEE VSMHVESCAN NNNNDLVDEG NGIGASSGSE LQSSVGAYLS 180 GKPPEGSVEV VLRLFRNIVK EPGNAKFRKI RMGNPKIREA VSDVAGGVEL LEGVGFELKE 240 EGGEMCAVME VPNEERLRLI NEAIRLLEPT KVEGQVQKIE EKPSVAPSGT GEPVEPKKID 300 REIRVFFSVP ESVAAKIQLP DSFYNLSAEE LKREADARKK KIAESQLLIP KSYKEKQAKA 360 ARKRYRRTLI RIQFPDGVVL QGVFAPWEPT SALYEFVSAS LKDPSLEFEL LDPVLVKRRV 420 IPHFPGAGER GSTLEDEELV PSALIKFRPV ETDSCVFTGL CNELLEISEP LN*

Sequence ? help Back to Top

Protein Sequence Length: 473 aa Download sequence Send to blast

MDDMKDKFKG FMKKVNTQLS SSSSGKFKGQ GRVLGGSSSA SSGSNNPIGS RYYQPDNPKP  60
TPTPSSLNSS SNFKSLPQKT PNSDQNKPAP INNSIPNRKP VDGFDPFDSL ITTGKRSQNG  120
SSLNVYECPI CGQSYKSEEE VSMHVESCAN NNNNDLVDEG NGIGASSGSE LQSSVGAYLS  180
GKPPEGSVEV VLRLFRNIVK EPGNAKFRKI RMGNPKIREA VSDVAGGVEL LEGVGFELKE  240
EGGEMCAVME VPNEERLRLI NEAIRLLEPT KVEGQVQKIE EKPSVAPSGT GEPVEPKKID  300
REIRVFFSVP ESVAAKIQLP DSFYNLSAEE LKREADARKK KIAESQLLIP KSYKEKQAKA  360
ARKRYRRTLI RIQFPDGVVL QGVFAPWEPT SALYEFVSAS LKDPSLEFEL LDPVLVKRRV  420
IPHFPGAGER GSTLEDEELV PSALIKFRPV ETDSCVFTGL CNELLEISEP LN*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5ifw_A	9e-12	314	447	19	146	Tether containing UBX domain for GLUT4
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Facilitates the interaction of SYP31 and CDC48A, thereby regulating an CDC48A membrane-associated function (Ref.8). Appears to act as a negative regulator mediating the powdery mildew-plant interaction (PubMed:19176722, PubMed:23301616). {ECO:0000269\|PubMed:19176722, ECO:0000269\|PubMed:23301616, ECO:0000269\|Ref.8}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Manes.15G133200.1.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Induced in response to powdery mildew and by benzothiadiazole (BTH) treatment. {ECO:0000269\|PubMed:19176722}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021594774.1	0.0	plant UBX domain-containing protein 2-like isoform X1
Swissprot	Q9ZU93	0.0	PUX2_ARATH; Plant UBX domain-containing protein 2
TrEMBL	A0A2C9UFU0	0.0	A0A2C9UFU0_MANES; Uncharacterized protein
STRING	cassava4.1_006400m	0.0	(Manihot esculenta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF8944	25	29

Link Out ? help Back to Top
Phytozome	Manes.15G133200.1.p

Publications ? help Back to Top
Suzuki T,Park H,Till EA,Lennarz WJ The PUB domain: a putative protein-protein interaction domain implicated in the ubiquitin-proteasome pathway. Biochem. Biophys. Res. Commun., 2001. 287(5): p. 1083-7 [PMID:11587532] Rancour DM,Park S,Knight SD,Bednarek SY Plant UBX domain-containing protein 1, PUX1, regulates the oligomeric structure and activity of arabidopsis CDC48. J. Biol. Chem., 2004. 279(52): p. 54264-74 [PMID:15498773] Chandran D,Rickert J,Cherk C,Dotson BR,Wildermuth MC Host cell ploidy underlying the fungal feeding site is a determinant of powdery mildew growth and reproduction. Mol. Plant Microbe Interact., 2013. 26(5): p. 537-45 [PMID:23301616]