PlantTFDB - Plant Transcription Factor Database @ CBI, PKU

cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot

Family

C2H2

Protein Properties

Length: 484aa MW: 52977.3 Da PI: 8.4898

Description

C2H2 family protein

Gene Model

Gene Model ID	Type	Source	Coding Sequence
Manes.13G141500.1.p	genome	JGI	View CDS

Signature Domain? help Back to Top

No.	Domain	Score	E-value	Start	End	HMM Start	HMM End
1	zf-C2H2	15.7	4.3e-05	61	81	3	23
ETTTTEEESSHHHHHHHHHHT CS zf-C2H2 3 CpdCgksFsrksnLkrHirtH 23 C++Cgk F r nL+ H r H Manes.13G141500.1.p 61 CEICGKGFQRDQNLQLHRRGH 81 *******************88 PP
2	zf-C2H2	12.8	0.00035	135	157	1	23
EEETTTTEEESSHHHHHHHHHHT CS zf-C2H2 1 ykCpdCgksFsrksnLkrHirtH 23 +kC +C+k++ +s+ k H +t+ Manes.13G141500.1.p 135 WKCDKCSKRYAVQSDWKAHSKTC 157 58*****************9998 PP

Protein Features ? help Back to Top

Database	Entry ID	E-value	Start	End	InterPro ID	Description
SuperFamily	SSF57667	1.33E-6	58	81	No hit	No description
Gene3D	G3DSA:3.30.160.60	4.2E-5	58	81	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
PROSITE profile	PS50157	11.489	59	81	IPR007087	Zinc finger, C2H2
SMART	SM00355	0.076	59	81	IPR015880	Zinc finger, C2H2-like
PROSITE pattern	PS00028	0	61	81	IPR007087	Zinc finger, C2H2
Gene3D	G3DSA:3.30.160.60	2.3E-4	123	156	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
SuperFamily	SSF57667	1.33E-6	130	155	No hit	No description
SMART	SM00355	140	135	155	IPR015880	Zinc finger, C2H2-like

Gene Ontology ? help Back to Top
GO Term	GO Category	GO Description
GO:0003676	Molecular Function	nucleic acid binding
GO:0046872	Molecular Function	metal ion binding

Sequence ? help Back to Top
Protein Sequence Length: 484 aa Download sequence Send to blast
MLENMDEEAI SSNGSFVQNP VAGSNLPSVK RKRNLPGNPD PEAEVIALSP KTLMATNRFL 60 CEICGKGFQR DQNLQLHRRG HNLPWKLKQR TSKEVRKRVY VCPEKTCVHH HPSRALGDLT 120 GIKKHFCRKH GEKKWKCDKC SKRYAVQSDW KAHSKTCGTR EYKCDCGTLF SRRDSFITHR 180 AFCDALAEET ARLNAEANIN GLAAVSANFN YHHLMGTSPV APNMAQHFPS IFKPISSNDQ 240 AMDQTPRGLS LWVSQEPQVH HEAIGSNNGM QEIHQLGSMV SSGTIFCEPL VSSSNPSPSD 300 HYQLNWPFLG NKFSSSNAHE ELTSTNSLPL NNVKDAAAAA QLVSVPSLYS TQQQSHQTSS 360 AANMSATALL QKAAQIGATS TDPSFLGSFG LKCNSNSIQE AGNKYCGLYG SNSINTSTNL 420 ASDVENSAGN DISSLNHQLQ MYPTAKRQKI QSDQENTGGQ TRDFLGVGVQ QAICHPSTMN 480 GWI*

Sequence ? help Back to Top

Protein Sequence Length: 484 aa Download sequence Send to blast

MLENMDEEAI SSNGSFVQNP VAGSNLPSVK RKRNLPGNPD PEAEVIALSP KTLMATNRFL  60
CEICGKGFQR DQNLQLHRRG HNLPWKLKQR TSKEVRKRVY VCPEKTCVHH HPSRALGDLT  120
GIKKHFCRKH GEKKWKCDKC SKRYAVQSDW KAHSKTCGTR EYKCDCGTLF SRRDSFITHR  180
AFCDALAEET ARLNAEANIN GLAAVSANFN YHHLMGTSPV APNMAQHFPS IFKPISSNDQ  240
AMDQTPRGLS LWVSQEPQVH HEAIGSNNGM QEIHQLGSMV SSGTIFCEPL VSSSNPSPSD  300
HYQLNWPFLG NKFSSSNAHE ELTSTNSLPL NNVKDAAAAA QLVSVPSLYS TQQQSHQTSS  360
AANMSATALL QKAAQIGATS TDPSFLGSFG LKCNSNSIQE AGNKYCGLYG SNSINTSTNL  420
ASDVENSAGN DISSLNHQLQ MYPTAKRQKI QSDQENTGGQ TRDFLGVGVQ QAICHPSTMN  480
GWI*

3D Structure ? help Back to Top

PDB ID	Evalue	Query Start	Query End	Hit Start	Hit End	Description
5b3h_C	1e-36	131	200	3	72	Zinc finger protein JACKDAW
5b3h_F	1e-36	131	200	3	72	Zinc finger protein JACKDAW
Search in ModeBase

Functional Description ? help Back to Top
Source	Description
UniProt	Transcription factor that regulates tissue boundaries and asymmetric cell division (PubMed:17785527, PubMed:25829440). Contributes to the sequestration of 'SHORT-ROOT' to the nucleus (PubMed:17785527, PubMed:25829440). Interacts with the SCR and MGP promoters (PubMed:21935722). Does not show transcription activity by itself, but regulates the transcription of downstream genes through interaction with other transcription factors (PubMed:21935722). Binds DNA via its zinc fingers (PubMed:24821766). Recognizes and binds to SCL3 promoter sequence 5'-AGACAA-3' to promotes its expression when in complex with RGA (PubMed:24821766). Positively involved in gibberellic acid (GA) signaling (PubMed:24821766). {ECO:0000269\|PubMed:17785527, ECO:0000269\|PubMed:21935722, ECO:0000269\|PubMed:24821766, ECO:0000269\|PubMed:25829440}.

Cis-element ? help Back to Top
Source	Link
PlantRegMap	Manes.13G141500.1.p

Regulation -- Description ? help Back to Top
Source	Description
UniProt	INDUCTION: Up-regulated by the transcription factor JKD, and down-regulated by SHR, SCR and itself. {ECO:0000269\|PubMed:21935722}.

Regulation -- PlantRegMap ? help Back to Top
Source	Upstream Regulator	Target Gene
PlantRegMap	Retrieve	-

Annotation -- Protein ? help Back to Top
Source	Hit ID	E-value	Description
Refseq	XP_021632251.1	0.0	zinc finger protein NUTCRACKER-like
Swissprot	Q9ZWA6	1e-159	IDD3_ARATH; Zinc finger protein MAGPIE
TrEMBL	A0A2C9UTQ8	0.0	A0A2C9UTQ8_MANES; Uncharacterized protein
STRING	cassava4.1_032898m	0.0	(Manihot esculenta)

Orthologous Group ? help Back to Top
Lineage	Orthologous Group ID	Taxa Number	Gene Number
Fabids	OGEF4626	29	51

Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID	E-value	Description
AT1G03840.1	1e-159	C2H2 family protein

Link Out ? help Back to Top
Phytozome	Manes.13G141500.1.p

Publications ? help Back to Top
Muñoz-Strale D,León G Identification of two highly specific pollen promoters using transcriptomic data. Plant Physiol. Biochem., 2014. 83: p. 292-9 [PMID:25208507] Moreno-Risueno MA, et al. Transcriptional control of tissue formation throughout root development. Science, 2015. 350(6259): p. 426-30 [PMID:26494755]