PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
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(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.08G145400.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family ERF
Protein Properties Length: 278aa    MW: 31562 Da    PI: 5.4461
Description ERF family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.08G145400.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1AP257.72.8e-183685255
                  AP2  2 gykGVrwdkkrgrWvAeIrdpsengkrkrfslgkfgtaeeAakaaiaarkkleg 55
                         ++ GVr+++ +grWvAeI+d +   ++ r +lg+f taeeAa+a+++a+  l+g
  Manes.08G145400.1.p 36 KFVGVRQRP-SGRWVAEIKDTT---QKIRMWLGTFETAEEAARAYDQAACLLRG 85
                         799******.7*********32...35**********************99987 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
Gene3DG3DSA:3.30.730.108.9E-283693IPR001471AP2/ERF domain
SuperFamilySSF541713.01E-193693IPR016177DNA-binding domain
PROSITE profilePS5103219.5723693IPR001471AP2/ERF domain
SMARTSM003803.0E-353699IPR001471AP2/ERF domain
PfamPF008475.9E-133685IPR001471AP2/ERF domain
PRINTSPR003679.4E-83748IPR001471AP2/ERF domain
CDDcd000187.15E-313792No hitNo description
PRINTSPR003679.4E-85975IPR001471AP2/ERF domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0006355Biological Processregulation of transcription, DNA-templated
GO:0003677Molecular FunctionDNA binding
GO:0003700Molecular Functiontranscription factor activity, sequence-specific DNA binding
Sequence ? help Back to Top
Protein Sequence    Length: 278 aa     Download sequence    Send to blast
MEIQFQQQKQ HKKSGVLMNK TSKFKGRNKS NNNNNKFVGV RQRPSGRWVA EIKDTTQKIR  60
MWLGTFETAE EAARAYDQAA CLLRGSNTRT NFITHVSLDS PLASRIRNLL NNKKSGQEQP  120
REEENLEIST PSTSILSREN LEVSTPSNST LSSSSSASDT NTPSNEIIND TQFFDNVYKP  180
DMSNCREEFE LGSSPSDLSW SSGPGFDRFP FSQEVLDFPR HTLLPETITS HLEFTEFDRM  240
KVERQISASL YAMNGVQEYM ETVHDPVEAF WDLPPIY*
3D Structure ? help Back to Top
Structure
PDB ID Evalue Query Start Query End Hit Start Hit End Description
5wx9_A8e-15341021281Ethylene-responsive transcription factor ERF096
Search in ModeBase
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor involved in symbiotic nodule signaling in response to rhizobial Nod factors (NFs) (PubMed:17449807, PubMed:17827349). Binds to the GCC-box (NF-responsive box) of ENOD11 promoter. Acts as transcriptional activator of NF-responsive box-containing target gene promoters in root hairs (PubMed:17827349). Functions as a transcriptional regulator required for root infection by symbiotic rhizobia, infection thread (IT) formation and maintenance, and nodule development. Necessary for NF-induced gene expression and spontaneous nodulation activated by CCAMK. Functions downstream of CCAMK to activate nodulation gene expression (PubMed:17449807). Involved in early stages of root nodule development. Functions redundantly with ERN2. Is essential with ERN2 for the initiation of root hair infection, and nodule organogenesis and development. Required for accurate expression of the NF signaling genes ENOD11 and ENOD12 (PubMed:23077241, PubMed:27208242). {ECO:0000269|PubMed:17449807, ECO:0000269|PubMed:17827349, ECO:0000269|PubMed:23077241, ECO:0000269|PubMed:27208242}.
UniProtTranscription factor involved in the symbiotic nodule signaling pathway in response to rhizobial stimulation. Functions as a transcriptional regulator required for root infection by symbiotic rhizobia, infection thread (IT) formation, and nodule development. May coordinate these processes (PubMed:28503742, PubMed:28028038, PubMed:28068194). Functions downstream of the CCAMK-CYCLOPS complex (PubMed:28503742, PubMed:28028038). Probably not involved in arbuscular mycorrhizal (AM) symbiosis (PubMed:28068194). {ECO:0000269|PubMed:28028038, ECO:0000269|PubMed:28068194, ECO:0000269|PubMed:28503742}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.08G145400.1.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Induced in nodules 7 days after rhizobial inoculation. {ECO:0000269|PubMed:28028038, ECO:0000269|PubMed:28503742}.
UniProtINDUCTION: Induced in roots from 1 to 21 day after inoculation with Sinorhizobium meliloti (PubMed:17449807). Induced by Nod factors in root hairs (PubMed:17827349). {ECO:0000269|PubMed:17449807, ECO:0000269|PubMed:17827349}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021621391.10.0ethylene-responsive transcription factor RAP2-11-like
SwissprotA0A1X9PY881e-107ERN1_LOTJA; Ethylene-responsive transcription factor ERN1
SwissprotA2Q5W11e-107ERN1_MEDTR; Ethylene-responsive transcription factor ERN1
TrEMBLA0A2C9VIB30.0A0A2C9VIB3_MANES; Uncharacterized protein
STRINGcassava4.1_013593m0.0(Manihot esculenta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF33413069
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT5G19790.16e-32related to AP2 11
Publications ? help Back to Top
  1. Cerri MR, et al.
    Medicago truncatula ERN transcription factors: regulatory interplay with NSP1/NSP2 GRAS factors and expression dynamics throughout rhizobial infection.
    Plant Physiol., 2012. 160(4): p. 2155-72
    [PMID:23077241]
  2. Tang H, et al.
    An improved genome release (version Mt4.0) for the model legume Medicago truncatula.
    BMC Genomics, 2014. 15: p. 312
    [PMID:24767513]
  3. Cerri MR, et al.
    The Symbiosis-Related ERN Transcription Factors Act in Concert to Coordinate Rhizobial Host Root Infection.
    Plant Physiol., 2016. 171(2): p. 1037-54
    [PMID:27208242]
  4. Yano K, et al.
    Function and evolution of a Lotus japonicus AP2/ERF family transcription factor that is required for development of infection threads.
    DNA Res., 2017. 24(2): p. 193-203
    [PMID:28028038]
  5. Kawaharada Y,James EK,Kelly S,Sandal N,Stougaard J
    The Ethylene Responsive Factor Required for Nodulation 1 (ERN1) Transcription Factor Is Required for Infection-Thread Formation in Lotus japonicus.
    Mol. Plant Microbe Interact., 2017. 30(3): p. 194-204
    [PMID:28068194]
  6. Cerri MR, et al.
    The ERN1 transcription factor gene is a target of the CCaMK/CYCLOPS complex and controls rhizobial infection in Lotus japonicus.
    New Phytol., 2017. 215(1): p. 323-337
    [PMID:28503742]