PlantTFDB
PlantRegMap/PlantTFDB v5.0
Plant Transcription Factor Database
Home  TFext  BLAST  Prediction  Download  Help  About  Links  PlantRegMap
(e.g., LFY)
Transcription Factor Information
Basic Information | Signature Domain | Sequence | 
Basic Information? help Back to Top
TF ID Manes.04G088800.1.p
Organism
Manihot esculenta
Taxonomic ID
Taxonomic Lineage
cellular organisms; Eukaryota; Viridiplantae; Streptophyta; Streptophytina; Embryophyta; Tracheophyta; Euphyllophyta; Spermatophyta; Magnoliophyta; Mesangiospermae; eudicotyledons; Gunneridae; Pentapetalae; rosids; fabids; Malpighiales; Euphorbiaceae; Crotonoideae; Manihoteae; Manihot
Family bHLH
Protein Properties Length: 393aa    MW: 43880 Da    PI: 6.52
Description bHLH family protein
Gene Model
Gene Model ID Type Source Coding Sequence
Manes.04G088800.1.pgenomeJGIView CDS
Signature Domain? help Back to Top
Signature Domain
No. Domain Score E-value Start End HMM Start HMM End
1HLH30.95e-10239286455
                          HHHHHHHHHHHHHHHHHHHHHCTSCCC...TTS-STCHHHHHHHHHHHHHHH CS
                  HLH   4 ahnerErrRRdriNsafeeLrellPkaskapskKlsKaeiLekAveYIksLq 55 
                          +h+ +Er RR++i +++  L++l+P +    +k   Ka +L + ++Y++sLq
  Manes.04G088800.1.p 239 SHSLAERVRREKISERMKYLQDLVPGC----NKITGKAGMLDEIINYVQSLQ 286
                          8**************************....999*****************9 PP
Protein Features ? help Back to Top
3D Structure
Database Entry ID E-value Start End InterPro ID Description
SuperFamilySSF474596.02E-17233303IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
CDDcd000831.68E-10233290No hitNo description
PROSITE profilePS5088815.618235285IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene3DG3DSA:4.10.280.102.5E-17235303IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
PfamPF000102.0E-7239286IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
SMARTSM003532.3E-9241291IPR011598Myc-type, basic helix-loop-helix (bHLH) domain
Gene Ontology ? help Back to Top
GO Term GO Category GO Description
GO:0046983Molecular Functionprotein dimerization activity
Sequence ? help Back to Top
Protein Sequence    Length: 393 aa     Download sequence    Send to blast
MNRALLPEML HCTDMTVLER QRARFKWQQE QELQQQQQQH HQQESFFGDL SGVFQLQLQH  60
QGLQGDLGEV VTRSVKPDPA SMDNGWPGLV GFGPSGYENN NGSGFDVNYA ISRTSSCQPA  120
VAGAAVDATV LAESREPVMS EKLSPGVGRE NLKKRKVDKL QHNTKVVAED ESRDKRVKGC  180
AGEGESMNTE KNNNKSSSTS KNSTKENSAE TSKDNSKVTE VQKPDYIHVR ARRGQATDSH  240
SLAERVRREK ISERMKYLQD LVPGCNKITG KAGMLDEIIN YVQSLQRQVE FLSMKLAAVN  300
PRLEFNIDNV FAKEAFPAPT TNFPETGMSS DLTNPVYLQF NQAQQQQQQQ QQQLFSSSGS  360
IPEMFIDPSC FTHIQPSSTW DAVSDLQKIF TM*
Functional Description ? help Back to Top
Source Description
UniProtTranscription factor that binds DNA to G box 5'-CACGTG-3' and, to a lower extent, to E-box 5'-CANNTG-3' in vitro. Binds to chromatin DNA of the FT gene and promotes its expression, and thus triggers flowering in response to blue light. {ECO:0000269|PubMed:18988809, ECO:0000269|PubMed:24130508}.
Cis-element ? help Back to Top
SourceLink
PlantRegMapManes.04G088800.1.p
Regulation -- Description ? help Back to Top
Source Description
UniProtINDUCTION: Accumulates strongly in response to blue light due to reduced preventing 26S proteasome-mediated degradation in an ADO1/ZTL and ADO2/LKP2 dependent manner, but levels decrease in the absence of blue light via 26S proteasome degradation (at protein level). {ECO:0000269|PubMed:24101505}.
Regulation -- PlantRegMap ? help Back to Top
Source Upstream Regulator Target Gene
PlantRegMapRetrieve-
Annotation -- Protein ? help Back to Top
Source Hit ID E-value Description
RefseqXP_021609352.10.0transcription factor bHLH63-like isoform X2
SwissprotQ8GY619e-64BH063_ARATH; Transcription factor bHLH63
TrEMBLA0A2C9W3C40.0A0A2C9W3C4_MANES; Uncharacterized protein
STRINGcassava4.1_009290m0.0(Manihot esculenta)
Orthologous Group ? help Back to Top
LineageOrthologous Group IDTaxa NumberGene Number
FabidsOGEF36183463
Best hit in Arabidopsis thaliana ? help Back to Top
Hit ID E-value Description
AT4G34530.12e-60cryptochrome-interacting basic-helix-loop-helix 1
Publications ? help Back to Top
  1. Skinner MK,Rawls A,Wilson-Rawls J,Roalson EH
    Basic helix-loop-helix transcription factor gene family phylogenetics and nomenclature.
    Differentiation, 2010. 80(1): p. 1-8
    [PMID:20219281]
  2. Yang D,Zhao W,Meng Y,Li H,Liu B
    A CIB1-LIKE transcription factor GmCIL10 from soybean positively regulates plant flowering.
    Sci China Life Sci, 2015. 58(3): p. 261-9
    [PMID:25651969]
  3. Katsura Y, et al.
    An optogenetic system for interrogating the temporal dynamics of Akt.
    Sci Rep, 2015. 5: p. 14589
    [PMID:26423353]
  4. Taslimi A, et al.
    Optimized second-generation CRY2-CIB dimerizers and photoactivatable Cre recombinase.
    Nat. Chem. Biol., 2016. 12(6): p. 425-30
    [PMID:27065233]
  5. Liu Q, et al.
    The Blue Light-Dependent Polyubiquitination and Degradation of Arabidopsis Cryptochrome2 Requires Multiple E3 Ubiquitin Ligases.
    Plant Cell Physiol., 2016. 57(10): p. 2175-2186
    [PMID:27516416]
  6. Pathak GP, et al.
    Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2.
    Nucleic Acids Res., 2017. 45(20): p. e167
    [PMID:28431041]
  7. Duan L, et al.
    Understanding CRY2 interactions for optical control of intracellular signaling.
    Nat Commun, 2017. 8(1): p. 547
    [PMID:28916751]
  8. Quejada JR, et al.
    Optimized light-inducible transcription in mammalian cells using Flavin Kelch-repeat F-box1/GIGANTEA and CRY2/CIB1.
    Nucleic Acids Res., 2017. 45(20): p. e172
    [PMID:29040770]
  9. Liu Y, et al.
    CIB1 and CO interact to mediate CRY2-dependent regulation of flowering.
    EMBO Rep., 2019.
    [PMID:30126927]